Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.255 -9999.0 0.0 -0.553 103.0 103.0 IHH 0.009 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.138 0.201 -9999.0 0.0 -0.427 169.0 169.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.137 0.2 0.424 169.0 -9999.0 0.0 169.0 SMO/beta Arrestin2 -0.003 0.16 -9999.0 0.0 -0.622 9.0 9.0 SMO -0.012 0.169 -9999.0 0.0 -0.592 12.0 12.0 AKT1 -0.014 0.166 -9999.0 0.0 -0.623 24.0 24.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.148 0.307 -9999.0 0.0 -0.722 117.0 117.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 STIL 0.011 0.125 -9999.0 0.0 -0.415 7.0 7.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.001 0.125 -9999.0 0.0 -0.391 3.0 3.0 PIK3CA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.154 0.467 -9999.0 0.0 -1.093 103.0 103.0 determination of left/right symmetry -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 PIK3R1 -0.055 0.219 -9999.0 0.0 -0.722 51.0 51.0 skeletal system development -0.15 0.459 -9999.0 0.0 -1.074 103.0 103.0 IHH N/Hhip 0.023 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 pancreas development 0.015 0.012 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.006 0.074 -9999.0 0.0 -0.722 5.0 5.0 PI3K -0.052 0.16 -9999.0 0.0 -0.539 51.0 51.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.217 0.343 -9999.0 0.0 -0.722 166.0 166.0 somite specification -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 SHH Np/Cholesterol/PTCH1 0.008 0.119 -9999.0 0.0 -0.378 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.005 0.041 -9999.0 0.0 -0.419 5.0 5.0 SHH Np/Cholesterol/Megalin -0.122 0.195 -9999.0 0.0 -0.429 149.0 149.0 SHH 0.022 0.057 -9999.0 0.0 -0.539 5.0 5.0 catabolic process -0.009 0.142 -9999.0 0.0 -0.377 9.0 9.0 SMO/Vitamin D3 0.004 0.144 -9999.0 0.0 -0.5 10.0 10.0 SHH Np/Cholesterol/Hhip -0.004 0.041 -9999.0 0.0 -0.419 5.0 5.0 LRP2 -0.19 0.331 -9999.0 0.0 -0.722 147.0 147.0 receptor-mediated endocytosis -0.118 0.168 -9999.0 0.0 -0.525 48.0 48.0 SHH Np/Cholesterol/BOC -0.098 0.18 -9999.0 0.0 -0.426 121.0 121.0 SHH Np/Cholesterol/CDO -0.007 0.057 -9999.0 0.0 -0.478 7.0 7.0 mesenchymal cell differentiation 0.004 0.041 0.416 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.012 0.121 -9999.0 0.0 -0.377 8.0 8.0 IHH N/PTCH2 0.023 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.012 0.056 -9999.0 0.0 -0.722 3.0 3.0 IHH N/PTCH1 -0.007 0.144 -9999.0 0.0 -0.379 9.0 9.0 Megalin/LRPAP1 -0.151 0.242 -9999.0 0.0 -0.539 147.0 147.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.043 -9999.0 0.0 -0.43 5.0 5.0 PTCH1 -0.009 0.143 -9999.0 0.0 -0.378 9.0 9.0 HHIP 0.015 0.012 -9999.0 0.0 -9999.0 0.0 0.0