Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.106 -9999.0 0.0 -0.293 60.0 60.0 epithelial cell differentiation -0.026 0.1 -9999.0 0.0 -0.386 37.0 37.0 CYFIP2 -0.002 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.058 0.085 -9999.0 0.0 -0.433 2.0 2.0 EGFR -0.375 0.367 -9999.0 0.0 -0.722 277.0 277.0 EPHA2 0.005 0.09 -9999.0 0.0 -0.722 8.0 8.0 MYO6 0.019 0.108 -9999.0 0.0 -0.366 38.0 38.0 CTNNB1 0.01 0.065 -9999.0 0.0 -0.722 4.0 4.0 ABI1/Sra1/Nap1 0.009 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.178 0.258 -9999.0 0.0 -0.555 156.0 156.0 CTNND1 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.019 0.104 -9999.0 0.0 -0.357 37.0 37.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.151 -9999.0 0.0 -0.369 79.0 79.0 EGF -0.235 0.349 -9999.0 0.0 -0.722 178.0 178.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.081 0.2 -9999.0 0.0 -0.563 65.0 65.0 cortical microtubule organization -0.026 0.1 -9999.0 0.0 -0.386 37.0 37.0 GO:0000145 0.019 0.099 -9999.0 0.0 -0.341 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.101 -9999.0 0.0 -0.39 37.0 37.0 MLLT4 0.002 0.101 -9999.0 0.0 -0.722 10.0 10.0 ARF6/GDP -0.025 0.085 -9999.0 0.0 -0.64 2.0 2.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.053 -9999.0 0.0 -0.411 8.0 8.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.034 0.101 -9999.0 0.0 -0.328 37.0 37.0 PVRL2 0.01 0.032 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.107 -9999.0 0.0 -0.362 38.0 38.0 ARF6/GTP -0.003 0.048 -9999.0 0.0 -0.374 8.0 8.0 CDH1 -0.032 0.179 -9999.0 0.0 -0.722 33.0 33.0 EGFR/EGFR/EGF/EGF -0.33 0.255 -9999.0 0.0 -0.455 382.0 382.0 RhoA/GDP -0.024 0.092 -9999.0 0.0 -0.358 37.0 37.0 actin cytoskeleton organization 0.026 0.103 -9999.0 0.0 -0.344 37.0 37.0 IGF-1R heterotetramer -0.023 0.153 -9999.0 0.0 -0.721 23.0 23.0 GIT1 0.015 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.023 0.153 -9999.0 0.0 -0.722 23.0 23.0 IGF1 -0.352 0.369 -9999.0 0.0 -0.722 262.0 262.0 DIAPH1 0.012 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.026 0.1 0.386 37.0 -9999.0 0.0 37.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.025 0.086 -9999.0 0.0 -0.642 2.0 2.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.026 0.106 -9999.0 0.0 -0.352 37.0 37.0 EFNA1 0.013 0.022 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.029 0.101 -9999.0 0.0 -0.337 37.0 37.0 Ephrin A1/EPHA2 -0.028 0.103 -9999.0 0.0 -0.36 43.0 43.0 SEC6/SEC8 -0.027 0.091 -9999.0 0.0 -0.437 4.0 4.0 MGAT3 -0.015 0.153 -9999.0 0.0 -0.375 79.0 79.0 HGF/MET -0.057 0.14 -9999.0 0.0 -0.367 84.0 84.0 HGF 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.106 -9999.0 0.0 -0.295 60.0 60.0 actin cable formation 0.08 0.081 -9999.0 0.0 -0.35 2.0 2.0 KIAA1543 0.028 0.101 -9999.0 0.0 -0.337 37.0 37.0 KIFC3 0.019 0.105 -9999.0 0.0 -0.362 37.0 37.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.019 0.105 -9999.0 0.0 -0.362 37.0 37.0 NCK1/GIT1 -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.026 0.1 -9999.0 0.0 -0.386 37.0 37.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.019 0.105 -9999.0 0.0 -0.362 37.0 37.0 PIP5K1C 0.019 0.105 -9999.0 0.0 -0.362 37.0 37.0 LIMA1 -0.016 0.151 -9999.0 0.0 -0.722 23.0 23.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.02 0.075 -9999.0 0.0 -0.536 2.0 2.0 adherens junction assembly 0.05 0.097 -9999.0 0.0 -0.368 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.214 0.216 -9999.0 0.0 -0.39 290.0 290.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.014 0.075 -9999.0 0.0 -0.539 10.0 10.0 MET -0.057 0.22 -9999.0 0.0 -0.722 52.0 52.0 PLEKHA7 0.019 0.105 -9999.0 0.0 -0.362 37.0 37.0 mol:GTP -0.004 0.052 -9999.0 0.0 -0.408 8.0 8.0 establishment of epithelial cell apical/basal polarity 0.044 0.108 -9999.0 0.0 -0.619 1.0 1.0 cortical actin cytoskeleton stabilization 0.002 0.106 -9999.0 0.0 -0.293 60.0 60.0 regulation of cell-cell adhesion 0.026 0.103 -9999.0 0.0 -0.344 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.106 -9999.0 0.0 -0.295 60.0 60.0