Signaling events mediated by PTP1B Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Jak2/Leptin Receptor -0.342 0.222 -9999.0 0.0 -0.498 338.0 338.0 PTP1B/AKT1 -0.173 0.131 -9999.0 0.0 -0.277 297.0 297.0 FYN 0.013 0.045 -9999.0 0.0 -0.722 2.0 2.0 p210 bcr-abl/PTP1B -0.206 0.148 -9999.0 0.0 -0.324 298.0 298.0 EGFR -0.387 0.372 -9999.0 0.0 -0.738 277.0 277.0 EGF/EGFR -0.478 0.32 -9999.0 0.0 -0.655 372.0 372.0 CSF1 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.013 0.02 -9999.0 0.0 -9999.0 0.0 0.0 INSR 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/N-cadherin -0.195 0.147 -9999.0 0.0 -0.309 297.0 297.0 Insulin Receptor/Insulin -0.121 0.084 -9999.0 0.0 -0.297 1.0 1.0 HCK 0.013 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.015 0.032 -9999.0 0.0 -0.722 1.0 1.0 TYK2 -0.187 0.142 -9999.0 0.0 -0.3 298.0 298.0 EGF -0.247 0.352 -9999.0 0.0 -0.738 178.0 178.0 YES1 0.015 0.032 -9999.0 0.0 -0.722 1.0 1.0 CAV1 -0.431 0.263 -9999.0 0.0 -0.567 388.0 388.0 TXN 0.004 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/IRS1/GRB2 -0.224 0.191 -9999.0 0.0 -0.342 331.0 331.0 cell migration 0.206 0.148 0.324 298.0 -9999.0 0.0 298.0 STAT3 0.014 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PRLR -0.021 0.07 -9999.0 0.0 -9999.0 0.0 0.0 ITGA2B 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CSF1R 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Prolactin Receptor/Prolactin 0.05 0.024 -9999.0 0.0 -9999.0 0.0 0.0 FGR 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/p130 Cas -0.187 0.142 -9999.0 0.0 -0.3 298.0 298.0 Crk/p130 Cas -0.172 0.139 -9999.0 0.0 -0.283 297.0 297.0 DOK1 -0.151 0.125 -9999.0 0.0 -0.261 177.0 177.0 JAK2 -0.094 0.088 -9999.0 0.0 -0.779 1.0 1.0 Jak2/Leptin Receptor/Leptin -0.361 0.23 -9999.0 0.0 -0.502 343.0 343.0 PIK3R1 -0.055 0.219 -9999.0 0.0 -0.722 51.0 51.0 PTPN1 -0.207 0.149 -9999.0 0.0 -0.326 298.0 298.0 LYN 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH2 -0.013 0.062 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.057 0.055 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CAT1/PTP1B -0.146 0.142 -9999.0 0.0 -0.3 98.0 98.0 CAPN1 0.003 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CSK 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.136 0.141 -9999.0 0.0 -0.5 51.0 51.0 mol:H2O2 -0.007 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.317 0.208 -9999.0 0.0 -0.49 256.0 256.0 negative regulation of transcription -0.093 0.088 -9999.0 0.0 -0.762 1.0 1.0 FCGR2A 0.013 0.023 -9999.0 0.0 -9999.0 0.0 0.0 FER 0.004 0.007 -9999.0 0.0 -9999.0 0.0 0.0 alphaIIb/beta3 Integrin -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BLK 0.002 0.045 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insulin/Shc 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.005 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LEPR -0.468 0.352 -9999.0 0.0 -0.724 344.0 344.0 BCAR1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p210 bcr-abl/Grb2 0.013 0.022 -9999.0 0.0 -9999.0 0.0 0.0 mol:NADPH -0.007 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TRPV6 0.026 0.059 -9999.0 0.0 -0.266 14.0 14.0 PRL 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SOCS3 0.003 0.249 -9999.0 0.0 -1.444 15.0 15.0 SPRY2 -0.485 0.35 -9999.0 0.0 -0.734 350.0 350.0 Insulin Receptor/Insulin/IRS1 -0.061 0.156 -9999.0 0.0 -0.463 69.0 69.0 CSF1/CSF1R -0.172 0.137 -9999.0 0.0 -0.282 294.0 294.0 Ras protein signal transduction 0.076 0.044 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 -0.081 0.249 -9999.0 0.0 -0.722 69.0 69.0 INS 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LEP -0.348 0.37 -9999.0 0.0 -0.725 258.0 258.0 STAT5B -0.157 0.122 -9999.0 0.0 -0.254 296.0 296.0 STAT5A -0.157 0.123 -9999.0 0.0 -0.255 296.0 296.0 GRB2 0.013 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB -0.187 0.142 -9999.0 0.0 -0.3 297.0 297.0 CSN2 0.071 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LAT -0.056 0.056 -9999.0 0.0 -9999.0 0.0 0.0 YBX1 0.018 0.017 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.0 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NOX4 -0.019 0.069 -9999.0 0.0 -0.738 1.0 1.0