IL23-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CCL2 -0.354 0.459 -9999.0 0.0 -0.988 99.0 99.0 IL23A -0.312 0.379 -9999.0 0.0 -1.019 40.0 40.0 NF kappa B1 p50/RelA/I kappa B alpha -0.352 0.305 -9999.0 0.0 -0.692 151.0 151.0 positive regulation of T cell mediated cytotoxicity -0.35 0.413 -9999.0 0.0 -0.687 274.0 274.0 ITGA3 -0.31 0.377 -9999.0 0.0 -1.015 41.0 41.0 IL17F -0.217 0.295 -9999.0 0.0 -0.642 71.0 71.0 IL12B 0.012 0.035 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) -0.339 0.397 -9999.0 0.0 -0.673 255.0 255.0 CD4 -0.309 0.372 -9999.0 0.0 -0.933 47.0 47.0 IL23 -0.303 0.366 -9999.0 0.0 -0.983 40.0 40.0 IL23R -0.04 0.129 -9999.0 0.0 -1.565 2.0 2.0 IL1B -0.324 0.393 -9999.0 0.0 -1.061 42.0 42.0 T-helper cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL24 -0.31 0.372 -9999.0 0.0 -0.813 76.0 76.0 TYK2 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0 STAT4 0.005 0.086 -9999.0 0.0 -0.722 7.0 7.0 STAT3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18RAP -0.046 0.206 -9999.0 0.0 -0.719 45.0 45.0 IL12RB1 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IL12Rbeta1/TYK2 0.006 0.026 -9999.0 0.0 -9999.0 0.0 0.0 IL23R/JAK2 -0.048 0.143 -9999.0 0.0 -1.181 3.0 3.0 positive regulation of chronic inflammatory response -0.35 0.413 -9999.0 0.0 -0.687 274.0 274.0 natural killer cell activation 0.003 0.009 0.079 2.0 -9999.0 0.0 2.0 JAK2 0.011 0.043 -9999.0 0.0 -0.761 1.0 1.0 PIK3R1 -0.055 0.219 -9999.0 0.0 -0.722 51.0 51.0 NFKB1 0.014 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.014 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of dendritic cell antigen processing and presentation -0.293 0.355 -9999.0 0.0 -0.935 40.0 40.0 ALOX12B -0.309 0.372 -9999.0 0.0 -0.806 77.0 77.0 CXCL1 -0.766 0.704 -9999.0 0.0 -1.348 304.0 304.0 T cell proliferation -0.35 0.413 -9999.0 0.0 -0.687 274.0 274.0 NFKBIA 0.013 0.033 -9999.0 0.0 -0.732 1.0 1.0 IL17A -0.153 0.249 -9999.0 0.0 -0.482 71.0 71.0 PI3K -0.387 0.339 -9999.0 0.0 -0.758 168.0 168.0 IFNG -0.012 0.03 0.152 2.0 -0.091 22.0 24.0 STAT3 (dimer) -0.36 0.321 -9999.0 0.0 -0.801 114.0 114.0 IL18R1 0.015 0.035 -9999.0 0.0 -0.719 1.0 1.0 IL23/IL23R/JAK2/TYK2/SOCS3 -0.177 0.247 -9999.0 0.0 -0.547 50.0 50.0 IL18/IL18R -0.01 0.146 -9999.0 0.0 -0.469 45.0 45.0 macrophage activation -0.021 0.016 -9999.0 0.0 -0.042 40.0 40.0 TNF -0.32 0.383 -9999.0 0.0 -1.016 42.0 42.0 STAT3/STAT4 -0.364 0.319 -9999.0 0.0 -0.707 163.0 163.0 STAT4 (dimer) -0.338 0.399 -9999.0 0.0 -0.674 254.0 254.0 IL18 0.003 0.055 -9999.0 0.0 -0.719 1.0 1.0 IL19 -0.315 0.374 -9999.0 0.0 -0.81 80.0 80.0 STAT5A (dimer) -0.335 0.393 -9999.0 0.0 -0.667 255.0 255.0 STAT1 -0.011 0.061 -9999.0 0.0 -9999.0 0.0 0.0 SOCS3 -0.005 0.123 -9999.0 0.0 -0.722 15.0 15.0 CXCL9 -0.327 0.391 -9999.0 0.0 -0.833 93.0 93.0 MPO -0.309 0.371 -9999.0 0.0 -0.893 54.0 54.0 positive regulation of humoral immune response -0.35 0.413 -9999.0 0.0 -0.687 274.0 274.0 IL23/IL23R/JAK2/TYK2 -0.359 0.426 -9999.0 0.0 -0.715 251.0 251.0 IL6 -0.927 0.657 -9999.0 0.0 -1.301 391.0 391.0 STAT5A 0.013 0.045 -9999.0 0.0 -0.722 2.0 2.0 IL2 0.019 0.034 -9999.0 0.0 -0.72 1.0 1.0 positive regulation of tyrosine phosphorylation of STAT protein 0.003 0.009 0.079 2.0 -9999.0 0.0 2.0 CD3E -0.309 0.371 -9999.0 0.0 -0.947 45.0 45.0 keratinocyte proliferation -0.35 0.413 -9999.0 0.0 -0.687 274.0 274.0 NOS2 -0.32 0.371 -9999.0 0.0 -0.627 274.0 274.0