p75(NTR)-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Sortilin/TRAF6 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Necdin/E2F1 -0.044 0.181 -9999.0 0.0 -0.375 112.0 112.0 proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E -0.002 0.149 -9999.0 0.0 -0.312 89.0 89.0 NGF (dimer)/p75(NTR)/BEX1 -0.006 0.139 -9999.0 0.0 -0.327 76.0 76.0 NT-4/5 (dimer)/p75(NTR) -0.041 0.149 -9999.0 0.0 -0.384 80.0 80.0 IKBKB 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.033 0.157 0.335 3.0 -0.32 96.0 99.0 IKBKG 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BDNF 0.038 0.048 -9999.0 0.0 -0.542 2.0 2.0 MGDIs/NGR/p75(NTR)/LINGO1 0.014 0.151 -9999.0 0.0 -0.333 72.0 72.0 FURIN 0.037 0.024 0.182 12.0 -9999.0 0.0 12.0 proBDNF (dimer)/p75(NTR)/Sortilin 0.002 0.146 -9999.0 0.0 -0.338 75.0 75.0 LINGO1 0.056 0.054 -9999.0 0.0 -9999.0 0.0 0.0 Sortilin/TRAF6/NRIF 0.033 0.03 -9999.0 0.0 -0.276 1.0 1.0 proBDNF (dimer) 0.038 0.048 -9999.0 0.0 -0.541 2.0 2.0 NTRK1 0.031 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RTN4R 0.041 0.036 -9999.0 0.0 -9999.0 0.0 0.0 neuron apoptosis -0.013 0.158 0.413 4.0 -0.468 16.0 20.0 IRAK1 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 -0.026 0.108 -9999.0 0.0 -0.339 54.0 54.0 ARHGDIA 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.076 0.055 -9999.0 0.0 -0.299 1.0 1.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 -0.007 0.144 -9999.0 0.0 -0.323 83.0 83.0 MAGEH1 0.019 0.094 -9999.0 0.0 -0.542 14.0 14.0 proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.078 0.203 -9999.0 0.0 -0.371 151.0 151.0 Mammalian IAPs/DIABLO 0.046 0.078 -9999.0 0.0 -0.312 17.0 17.0 proNGF (dimer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.044 0.037 -9999.0 0.0 -9999.0 0.0 0.0 APP 0.029 0.06 -9999.0 0.0 -0.542 5.0 5.0 NT-4/5 (dimer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZNF274 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP/RHOGDI -0.01 0.118 -9999.0 0.0 -0.291 74.0 74.0 NGF -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell cycle arrest -0.037 0.109 0.208 30.0 -0.268 74.0 104.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK -0.016 0.095 -9999.0 0.0 -0.254 58.0 58.0 NT-4/5 (dimer)/p75(NTR)/TRAF6 -0.018 0.136 -9999.0 0.0 -0.339 76.0 76.0 NCSTN 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.018 0.149 -9999.0 0.0 -0.352 79.0 79.0 PSENEN 0.035 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:ceramide -0.021 0.126 -9999.0 0.0 -0.308 74.0 74.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.012 0.078 -9999.0 0.0 -0.21 57.0 57.0 p75(NTR)/beta APP -0.025 0.164 -9999.0 0.0 -0.407 76.0 76.0 BEX1 0.055 0.051 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.053 0.118 -9999.0 0.0 -0.335 76.0 76.0 NGF (dimer) 0.005 0.126 -9999.0 0.0 -0.307 65.0 65.0 MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.028 0.146 -9999.0 0.0 -0.306 70.0 70.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.542 47.0 47.0 RAC1/GTP -0.013 0.116 -9999.0 0.0 -0.29 75.0 75.0 MYD88 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CHUK 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/p75(NTR)/PKA -0.018 0.15 -9999.0 0.0 -0.353 79.0 79.0 RHOB 0.033 0.037 -9999.0 0.0 -0.542 2.0 2.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAGE-G1/E2F1 0.058 0.036 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer) -0.115 0.254 -9999.0 0.0 -0.541 134.0 134.0 TP53 -0.027 0.129 0.374 8.0 -0.286 71.0 79.0 PRDM4 -0.018 0.13 -9999.0 0.0 -0.31 74.0 74.0 BDNF (dimer) 0.057 0.167 -9999.0 0.0 -0.311 70.0 70.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SORT1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 activation of caspase activity -0.006 0.145 -9999.0 0.0 -0.308 89.0 89.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.001 0.132 -9999.0 0.0 -0.311 74.0 74.0 RHOC 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.028 0.139 0.301 6.0 -0.334 66.0 72.0 DIABLO 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SMPD2 -0.021 0.126 -9999.0 0.0 -0.31 74.0 74.0 APH1B 0.033 0.027 -9999.0 0.0 -0.542 1.0 1.0 APH1A 0.032 0.029 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin -0.017 0.135 -9999.0 0.0 -0.339 74.0 74.0 PSEN1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer)/p75(NTR) -0.128 0.235 -9999.0 0.0 -0.439 173.0 173.0 MAPK8 -0.025 0.135 0.294 8.0 -0.327 64.0 72.0 MAPK9 -0.024 0.132 0.28 7.0 -0.325 63.0 70.0 APAF1 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NTF3 -0.115 0.254 -9999.0 0.0 -0.542 134.0 134.0 NTF4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDN -0.099 0.241 -9999.0 0.0 -0.542 117.0 117.0 RAC1/GDP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA-B-C/GDP 0.009 0.137 -9999.0 0.0 -0.3 73.0 73.0 p75 CTF/Sortilin/TRAF6/NRIF 0.081 0.027 -9999.0 0.0 -9999.0 0.0 0.0 RhoA-B-C/GTP -0.018 0.148 -9999.0 0.0 -0.351 79.0 79.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.027 0.141 -9999.0 0.0 -0.298 71.0 71.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.017 0.142 -9999.0 0.0 -0.311 75.0 75.0 PRKACB 0.035 0.083 -9999.0 0.0 -0.542 8.0 8.0 proBDNF (dimer)/p75 ECD 0.052 0.037 -9999.0 0.0 -0.399 2.0 2.0 ChemicalAbstracts:86-01-1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 0.017 0.108 -9999.0 0.0 -0.542 17.0 17.0 BIRC2 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 neuron projection morphogenesis -0.101 0.162 -9999.0 0.0 -0.393 99.0 99.0 BAD -0.025 0.151 0.397 9.0 -0.335 64.0 73.0 RIPK2 0.029 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NGFR -0.054 0.204 -9999.0 0.0 -0.542 76.0 76.0 CYCS -0.009 0.126 0.274 5.0 -0.294 67.0 72.0 ADAM17 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2 -0.003 0.121 -9999.0 0.0 -0.307 62.0 62.0 BCL2L11 -0.024 0.152 0.405 9.0 -0.334 64.0 73.0 BDNF (dimer)/p75(NTR) -0.02 0.16 -9999.0 0.0 -0.393 77.0 77.0 PI3K -0.03 0.162 -9999.0 0.0 -0.338 100.0 100.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 -0.0 0.131 -9999.0 0.0 -0.311 74.0 74.0 NDNL2 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI 0.035 0.018 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/p75(NTR) -0.041 0.149 -9999.0 0.0 -0.384 80.0 80.0 ChemicalAbstracts:146-91-8 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.006 0.133 -9999.0 0.0 -0.304 74.0 74.0 TRAF6 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.031 0.027 -9999.0 0.0 -0.542 1.0 1.0 oligodendrocyte cell fate commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 -0.027 0.127 -9999.0 0.0 -0.329 74.0 74.0 SQSTM1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NGFRAP1 0.01 0.117 -9999.0 0.0 -0.542 22.0 22.0 CASP3 -0.023 0.145 0.392 9.0 -0.314 65.0 74.0 E2F1 0.051 0.049 -9999.0 0.0 -9999.0 0.0 0.0 CASP9 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex 0.03 0.086 -9999.0 0.0 -0.303 1.0 1.0 NGF (dimer)/TRKA 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MMP7 -0.041 0.189 -9999.0 0.0 -0.542 64.0 64.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.012 0.131 -9999.0 0.0 -0.296 73.0 73.0 MMP3 0.095 0.1 -9999.0 0.0 -0.542 5.0 5.0 APAF-1/Caspase 9 -0.033 0.103 -9999.0 0.0 -0.409 6.0 6.0