Regulation of Telomerase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Telomerase catalytic core complex 0.003 0.179 -9999.0 0.0 -0.745 11.0 11.0 RAD9A 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.308 0.265 -9999.0 0.0 -0.464 356.0 356.0 IFNAR2 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.005 0.117 -9999.0 0.0 -0.382 13.0 13.0 ER alpha/Oestrogen -0.041 0.186 -9999.0 0.0 -0.386 110.0 110.0 NFX1/SIN3/HDAC complex 0.035 0.075 -9999.0 0.0 -0.347 12.0 12.0 EGF -0.147 0.269 -9999.0 0.0 -0.54 163.0 163.0 SMG5 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SMG6 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SP3/HDAC2 0.056 0.025 -9999.0 0.0 -9999.0 0.0 0.0 TERT/c-Abl 0.012 0.17 -9999.0 0.0 -0.69 11.0 11.0 SAP18 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex 0.049 0.033 -9999.0 0.0 -9999.0 0.0 0.0 WT1 0.088 0.071 -9999.0 0.0 -9999.0 0.0 0.0 WRN 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SP1 0.041 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SP3 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TERF2IP 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/Nucleolin 0.031 0.164 -9999.0 0.0 -0.624 11.0 11.0 Mad/Max 0.055 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TERT -0.003 0.181 -9999.0 0.0 -0.779 11.0 11.0 CCND1 0.036 0.256 0.567 10.0 -1.037 14.0 24.0 MAX 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RBBP7 0.039 0.023 -9999.0 0.0 -9999.0 0.0 0.0 RBBP4 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TERF2 0.027 0.028 -9999.0 0.0 -0.489 1.0 1.0 PTGES3 0.033 0.026 -9999.0 0.0 -0.542 1.0 1.0 SIN3A 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/911 0.04 0.06 -9999.0 0.0 -0.45 2.0 2.0 CDKN1B 0.044 0.11 0.315 1.0 -0.609 10.0 11.0 RAD1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 XRCC5 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SAP30 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/PARP2 0.043 0.029 -9999.0 0.0 -0.389 1.0 1.0 UBE3A 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUN -0.065 0.218 -9999.0 0.0 -0.54 89.0 89.0 E6 0.002 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HPV-16 E6/E6AP 0.029 0.012 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.351 0.269 -9999.0 0.0 -0.54 344.0 344.0 IFN-gamma/IRF1 0.083 0.084 0.275 28.0 -0.318 10.0 38.0 PARP2 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BLM 0.075 0.068 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase 0.004 0.095 -9999.0 0.0 -0.63 5.0 5.0 IRF1 0.046 0.048 0.197 4.0 -0.183 9.0 13.0 ESR1 -0.057 0.254 -9999.0 0.0 -0.541 106.0 106.0 KU/TER 0.048 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ATM/TRF2 0.037 0.033 -9999.0 0.0 -0.288 1.0 1.0 ubiquitin-dependent protein catabolic process 0.043 0.069 -9999.0 0.0 -0.352 7.0 7.0 HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.043 0.07 -9999.0 0.0 -0.36 7.0 7.0 HDAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 HDAC2 0.039 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ATM 0.017 0.021 0.212 1.0 -9999.0 0.0 1.0 SMAD3 0.01 0.017 -9999.0 0.0 -9999.0 0.0 0.0 ABL1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MXD1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MRE11A 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HUS1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 TERT/NF kappa B1/14-3-3 0.027 0.186 -9999.0 0.0 -0.738 11.0 11.0 NR2F2 0.008 0.094 -9999.0 0.0 -0.547 13.0 13.0 MAPK3 0.019 0.022 -9999.0 0.0 -0.397 1.0 1.0 MAPK1 0.019 0.022 -9999.0 0.0 -0.397 1.0 1.0 TGFB1/TGF beta receptor Type II 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 HNRNPC 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.017 0.021 0.212 1.0 -9999.0 0.0 1.0 NBN 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.267 0.286 -9999.0 0.0 -0.539 269.0 269.0 mol:Oestrogen 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EGF/EGFR -0.305 0.259 -9999.0 0.0 -0.46 355.0 355.0 MYC -0.001 0.123 -9999.0 0.0 -0.541 25.0 25.0 IL2 0.04 0.031 -9999.0 0.0 -0.54 1.0 1.0 KU 0.048 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RAD50 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 HSP90AA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TGFB1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/BLM 0.066 0.057 -9999.0 0.0 -0.389 1.0 1.0 FRAP1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU/TERT 0.025 0.177 -9999.0 0.0 -0.695 11.0 11.0 SP1/HDAC2 0.061 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PINX1 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/EST1A 0.024 0.161 -9999.0 0.0 -0.623 11.0 11.0 Smad3/Myc 0.005 0.081 -9999.0 0.0 -0.343 25.0 25.0 911 complex 0.062 0.026 0.259 1.0 -9999.0 0.0 1.0 IFNG 0.066 0.074 -9999.0 0.0 -0.536 1.0 1.0 Telomerase/PinX1 0.013 0.156 -9999.0 0.0 -0.623 11.0 11.0 Telomerase/AKT1/mTOR/p70S6K 0.022 0.123 0.297 1.0 -0.492 15.0 16.0 SIN3B 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/EST1B 0.03 0.155 -9999.0 0.0 -0.655 9.0 9.0 response to DNA damage stimulus -0.001 0.03 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex/TRF2/Rap1 0.062 0.052 -9999.0 0.0 -0.309 1.0 1.0 TRF2/WRN 0.036 0.03 -9999.0 0.0 -0.389 1.0 1.0 Telomerase/hnRNP C1/C2 0.031 0.162 -9999.0 0.0 -0.64 10.0 10.0 E2F1 0.056 0.05 -9999.0 0.0 -9999.0 0.0 0.0 ZNFX1 0.034 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIF1 0.039 0.029 -9999.0 0.0 -9999.0 0.0 0.0 NCL 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DKC1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 telomeric DNA binding 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0