Endothelins Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.1 0.167 -9999.0 0.0 -0.349 138.0 138.0 PTK2B 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.167 0.288 -9999.0 0.0 -0.722 79.0 79.0 EDN1 -0.158 0.253 -9999.0 0.0 -0.538 154.0 154.0 EDN3 -0.391 0.25 -9999.0 0.0 -0.542 376.0 376.0 EDN2 0.1 0.08 -9999.0 0.0 -0.542 1.0 1.0 HRAS/GDP -0.254 0.235 -9999.0 0.0 -0.458 234.0 234.0 ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.128 0.182 -9999.0 0.0 -0.374 131.0 131.0 ADCY4 -0.083 0.153 0.335 1.0 -0.301 142.0 143.0 ADCY5 -0.081 0.148 -9999.0 0.0 -0.296 139.0 139.0 ADCY6 -0.081 0.15 0.335 1.0 -0.296 142.0 143.0 ADCY7 -0.078 0.15 0.335 1.0 -0.295 137.0 138.0 ADCY1 -0.081 0.149 -9999.0 0.0 -0.296 139.0 139.0 ADCY2 -0.082 0.156 0.335 1.0 -0.304 142.0 143.0 ADCY3 -0.082 0.149 -9999.0 0.0 -0.296 143.0 143.0 ADCY8 -0.068 0.134 -9999.0 0.0 -0.296 103.0 103.0 ADCY9 -0.075 0.143 -9999.0 0.0 -0.297 124.0 124.0 arachidonic acid secretion -0.524 0.344 -9999.0 0.0 -0.69 379.0 379.0 ETB receptor/Endothelin-1/Gq/GTP -0.208 0.211 -9999.0 0.0 -0.372 273.0 273.0 GNAO1 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-1/G12/GTP -0.092 0.161 -9999.0 0.0 -0.322 145.0 145.0 ETA receptor/Endothelin-1/Gs/GTP -0.088 0.153 -9999.0 0.0 -0.308 145.0 145.0 mol:GTP -0.007 0.008 -9999.0 0.0 -9999.0 0.0 0.0 COL3A1 -0.1 0.167 -9999.0 0.0 -0.347 140.0 140.0 EDNRB -0.212 0.285 -9999.0 0.0 -0.534 224.0 224.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYSLTR2 -0.099 0.166 -9999.0 0.0 -0.347 133.0 133.0 CYSLTR1 -0.101 0.175 0.386 2.0 -0.358 120.0 122.0 SLC9A1 -0.068 0.116 -9999.0 0.0 -0.249 90.0 90.0 mol:GDP -0.272 0.249 -9999.0 0.0 -0.478 246.0 246.0 SLC9A3 -0.392 0.393 -9999.0 0.0 -0.721 250.0 250.0 RAF1 -0.355 0.268 -9999.0 0.0 -0.514 332.0 332.0 JUN -0.254 0.434 -9999.0 0.0 -1.036 111.0 111.0 JAK2 -0.1 0.166 -9999.0 0.0 -0.347 142.0 142.0 mol:IP3 -0.208 0.216 -9999.0 0.0 -0.424 201.0 201.0 ETA receptor/Endothelin-1 -0.12 0.195 -9999.0 0.0 -0.404 147.0 147.0 PLCB1 -0.048 0.199 -9999.0 0.0 -0.546 70.0 70.0 PLCB2 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-3 -0.289 0.186 -9999.0 0.0 -0.4 375.0 375.0 FOS -0.684 0.432 -9999.0 0.0 -0.955 365.0 365.0 Gai/GDP -0.196 0.354 -9999.0 0.0 -0.944 82.0 82.0 CRK 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca ++ -0.261 0.264 -9999.0 0.0 -0.535 203.0 203.0 BCAR1 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.211 0.21 -9999.0 0.0 -0.415 208.0 208.0 GNAQ -0.008 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.026 0.062 -9999.0 0.0 -0.542 6.0 6.0 GNAL 0.03 0.044 -9999.0 0.0 -0.542 3.0 3.0 Gs family/GDP -0.245 0.226 -9999.0 0.0 -0.446 232.0 232.0 ETA receptor/Endothelin-1/Gq/GTP -0.097 0.153 -9999.0 0.0 -0.309 129.0 129.0 MAPK14 -0.223 0.22 -9999.0 0.0 -0.407 249.0 249.0 TRPC6 -0.177 0.309 -9999.0 0.0 -0.772 79.0 79.0 GNAI2 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.171 0.276 -9999.0 0.0 -0.542 183.0 183.0 ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.234 0.232 -9999.0 0.0 -0.416 265.0 265.0 ETB receptor/Endothelin-2 -0.105 0.219 -9999.0 0.0 -0.339 222.0 222.0 ETB receptor/Endothelin-3 -0.42 0.27 -9999.0 0.0 -0.545 395.0 395.0 ETB receptor/Endothelin-1 -0.265 0.279 -9999.0 0.0 -0.476 297.0 297.0 MAPK3 -0.606 0.393 -9999.0 0.0 -0.837 369.0 369.0 MAPK1 -0.623 0.409 -9999.0 0.0 -0.86 369.0 369.0 Rac1/GDP -0.252 0.235 -9999.0 0.0 -0.458 233.0 233.0 cAMP biosynthetic process -0.032 0.148 0.384 4.0 -0.356 26.0 30.0 MAPK8 -0.179 0.305 -9999.0 0.0 -0.66 114.0 114.0 SRC 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ETB receptor/Endothelin-1/Gi/GTP -0.277 0.289 -9999.0 0.0 -0.556 223.0 223.0 p130Cas/CRK/Src/PYK2 -0.274 0.289 -9999.0 0.0 -0.574 199.0 199.0 mol:K + -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/GDP -0.252 0.234 -9999.0 0.0 -0.454 236.0 236.0 COL1A2 -0.226 0.271 0.396 2.0 -0.479 220.0 222.0 EntrezGene:2778 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-2 0.072 0.078 0.272 1.0 -0.401 3.0 4.0 mol:DAG -0.209 0.217 -9999.0 0.0 -0.424 202.0 202.0 MAP2K2 -0.471 0.318 -9999.0 0.0 -0.644 371.0 371.0 MAP2K1 -0.47 0.318 0.356 1.0 -0.645 371.0 372.0 EDNRA 0.006 0.058 -9999.0 0.0 -0.546 2.0 2.0 positive regulation of muscle contraction -0.091 0.145 -9999.0 0.0 -0.307 138.0 138.0 Gq family/GDP -0.213 0.218 -9999.0 0.0 -0.442 184.0 184.0 HRAS/GTP -0.266 0.239 -9999.0 0.0 -0.451 259.0 259.0 PRKCH -0.213 0.213 -9999.0 0.0 -0.434 190.0 190.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.195 0.212 -9999.0 0.0 -0.435 173.0 173.0 PRKCB -0.213 0.211 -9999.0 0.0 -0.414 212.0 212.0 PRKCE -0.211 0.21 -9999.0 0.0 -0.434 188.0 188.0 PRKCD -0.211 0.212 -9999.0 0.0 -0.436 188.0 188.0 PRKCG -0.212 0.212 0.304 1.0 -0.434 190.0 191.0 regulation of vascular smooth muscle contraction -0.807 0.507 -9999.0 0.0 -1.124 365.0 365.0 PRKCQ -0.203 0.213 -9999.0 0.0 -0.44 178.0 178.0 PLA2G4A -0.593 0.402 -9999.0 0.0 -0.782 379.0 379.0 GNA14 0.027 0.073 -9999.0 0.0 -0.546 4.0 4.0 GNA15 0.021 0.031 -9999.0 0.0 -9999.0 0.0 0.0 GNA12 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.019 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.092 0.16 -9999.0 0.0 -0.323 143.0 143.0 MMP1 0.169 0.151 0.409 84.0 -9999.0 0.0 84.0