E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.148 -9999.0 0.0 -0.432 42.0 42.0 KLHL20 0.042 0.115 0.306 41.0 -0.259 14.0 55.0 CYFIP2 0.051 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.003 0.117 0.313 7.0 -0.298 28.0 35.0 ENAH -0.031 0.143 -9999.0 0.0 -0.43 37.0 37.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.052 -9999.0 0.0 -0.542 4.0 4.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.275 3.0 3.0 ABI1/Sra1/Nap1 -0.015 0.04 -9999.0 0.0 -0.171 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.095 -9999.0 0.0 -0.31 26.0 26.0 RAPGEF1 -0.029 0.142 0.312 2.0 -0.397 40.0 42.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.164 -9999.0 0.0 -0.438 51.0 51.0 CRK -0.027 0.145 0.347 1.0 -0.415 45.0 46.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.342 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.309 3.0 3.0 DLG1 -0.04 0.158 -9999.0 0.0 -0.429 50.0 50.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.199 14.0 14.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.542 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.257 14.0 14.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.095 -9999.0 0.0 -0.315 33.0 33.0 TIAM1 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.047 0.089 -9999.0 0.0 -0.292 26.0 26.0 AKT1 -0.007 0.056 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.542 47.0 47.0 CDH1 0.007 0.118 -9999.0 0.0 -0.542 22.0 22.0 RhoA/GDP 0.001 0.117 0.306 7.0 -0.299 27.0 34.0 actin cytoskeleton organization 0.037 0.093 0.253 45.0 -0.186 14.0 59.0 CDC42/GDP 0.0 0.116 0.306 7.0 -0.299 27.0 34.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.219 39.0 39.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.096 -9999.0 0.0 -0.31 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.29 26.0 26.0 mol:GDP -0.018 0.124 0.31 7.0 -0.335 35.0 42.0 CDC42/GTP/IQGAP1 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.008 0.12 0.314 6.0 -0.306 27.0 33.0 RAC1/GTP/IQGAP1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.212 23.0 -0.225 11.0 34.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.158 -9999.0 0.0 -0.44 47.0 47.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.242 3.0 3.0 WASF2 0.02 0.043 0.119 33.0 -0.11 4.0 37.0 Rap1/GTP 0.012 0.087 0.267 2.0 -0.31 3.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.093 -9999.0 0.0 -0.299 21.0 21.0 CCND1 0.017 0.08 0.25 20.0 -0.283 11.0 31.0 VAV2 -0.019 0.193 0.391 3.0 -0.608 21.0 24.0 RAP1/GDP 0.011 0.101 0.312 3.0 -0.334 5.0 8.0 adherens junction assembly -0.034 0.154 -9999.0 0.0 -0.425 47.0 47.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.088 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/beta catenin -0.006 0.088 -9999.0 0.0 -0.335 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.157 -9999.0 0.0 -0.429 50.0 50.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.014 0.146 0.284 60.0 -0.416 18.0 78.0 E-cadherin/beta catenin/alpha catenin 0.036 0.095 -9999.0 0.0 -0.338 26.0 26.0 ITGAE 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.032 0.167 -9999.0 0.0 -0.448 51.0 51.0