Glucocorticoid receptor regulatory network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PCK2 0.108 0.114 0.522 5.0 -9999.0 0.0 5.0 SMARCC2 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SMARCC1 0.035 0.02 -9999.0 0.0 -9999.0 0.0 0.0 TBX21 -0.121 0.223 0.406 1.0 -0.716 40.0 41.0 SUMO2 0.002 0.025 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) 0.073 0.07 0.289 25.0 -9999.0 0.0 25.0 FKBP4 0.037 0.027 -9999.0 0.0 -9999.0 0.0 0.0 FKBP5 0.025 0.082 -9999.0 0.0 -0.542 10.0 10.0 GR alpha/HSP90/FKBP51/HSP90 0.132 0.143 0.312 67.0 -0.359 4.0 71.0 PRL -0.06 0.11 -9999.0 0.0 -9999.0 0.0 0.0 cortisol/GR alpha (dimer)/TIF2 0.212 0.264 0.512 190.0 -9999.0 0.0 190.0 RELA -0.092 0.115 0.278 3.0 -0.251 37.0 40.0 FGG 0.234 0.232 0.451 222.0 -9999.0 0.0 222.0 GR beta/TIF2 0.114 0.142 0.294 124.0 -0.332 4.0 128.0 IFNG -0.387 0.337 -9999.0 0.0 -0.717 205.0 205.0 apoptosis -0.249 0.181 -9999.0 0.0 -0.549 39.0 39.0 CREB1 0.058 0.042 -9999.0 0.0 -9999.0 0.0 0.0 histone acetylation 0.035 0.137 0.389 40.0 -0.318 10.0 50.0 BGLAP -0.093 0.145 -9999.0 0.0 -0.452 14.0 14.0 GR/PKAc 0.149 0.14 0.331 65.0 -0.312 3.0 68.0 NF kappa B1 p50/RelA -0.156 0.195 0.48 3.0 -0.338 136.0 139.0 SMARCD1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MDM2 0.116 0.1 0.207 226.0 -9999.0 0.0 226.0 GATA3 0.044 0.166 -9999.0 0.0 -0.536 33.0 33.0 AKT1 0.028 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CSF2 -0.008 0.108 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.002 0.027 -9999.0 0.0 -9999.0 0.0 0.0 NR1I3 -0.188 0.165 -9999.0 0.0 -0.559 8.0 8.0 CSN2 0.192 0.192 0.372 212.0 -9999.0 0.0 212.0 BRG1/BAF155/BAF170/BAF60A 0.084 0.028 -9999.0 0.0 -9999.0 0.0 0.0 NFATC1 0.038 0.038 -9999.0 0.0 -0.536 2.0 2.0 POU2F1 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1A 0.021 0.117 -9999.0 0.0 -1.429 2.0 2.0 response to stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to UV -0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SFN 0.033 0.04 -9999.0 0.0 -0.542 2.0 2.0 GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.138 0.14 0.341 35.0 -0.398 2.0 37.0 prolactin receptor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGR1 -0.654 0.331 -9999.0 0.0 -0.802 426.0 426.0 JUN -0.21 0.241 0.392 1.0 -0.489 158.0 159.0 IL4 -0.119 0.147 -9999.0 0.0 -0.479 14.0 14.0 CDK5R1 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 cortisol/GR alpha (monomer)/AP-1 -0.352 0.235 -9999.0 0.0 -0.494 330.0 330.0 GR alpha/HSP90/FKBP51/HSP90/PP5C 0.146 0.139 0.338 44.0 -0.395 2.0 46.0 cortisol/GR alpha (monomer) 0.291 0.308 0.57 242.0 -9999.0 0.0 242.0 NCOA2 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 response to hypoxia 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.416 0.262 -9999.0 0.0 -0.574 361.0 361.0 AP-1/NFAT1-c-4 -0.576 0.408 -9999.0 0.0 -0.816 348.0 348.0 AFP -0.177 0.202 -9999.0 0.0 -0.589 25.0 25.0 SUV420H1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IRF1 0.206 0.178 0.429 115.0 -9999.0 0.0 115.0 TP53 0.046 0.034 -9999.0 0.0 -0.513 1.0 1.0 PPP5C 0.036 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KRT17 -0.895 0.649 -9999.0 0.0 -1.368 326.0 326.0 KRT14 -0.829 0.628 -9999.0 0.0 -1.301 325.0 325.0 TBP 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.178 0.144 0.3 290.0 -9999.0 0.0 290.0 HDAC1 0.029 0.012 -9999.0 0.0 -9999.0 0.0 0.0 HDAC2 0.029 0.022 -9999.0 0.0 -9999.0 0.0 0.0 AP-1 -0.58 0.411 -9999.0 0.0 -0.822 348.0 348.0 MAPK14 0.014 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.009 0.082 -9999.0 0.0 -0.55 10.0 10.0 MAPK11 0.0 0.026 -9999.0 0.0 -9999.0 0.0 0.0 KRT5 -0.946 0.633 -9999.0 0.0 -1.347 356.0 356.0 interleukin-1 receptor activity -0.003 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCOA1 0.037 0.027 -9999.0 0.0 -0.538 1.0 1.0 STAT1 0.073 0.07 0.29 25.0 -9999.0 0.0 25.0 CGA -0.084 0.159 -9999.0 0.0 -0.515 7.0 7.0 NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.146 0.186 0.346 174.0 -0.393 1.0 175.0 MAPK3 0.001 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.012 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ICAM1 -0.254 0.251 0.597 2.0 -0.527 147.0 149.0 NFKB1 -0.094 0.112 0.325 1.0 -0.266 20.0 21.0 MAPK8 -0.146 0.189 0.57 1.0 -0.366 142.0 143.0 MAPK9 0.013 0.023 -9999.0 0.0 -9999.0 0.0 0.0 cortisol/GR alpha (dimer) -0.259 0.187 -9999.0 0.0 -0.574 40.0 40.0 BAX 0.027 0.076 -9999.0 0.0 -9999.0 0.0 0.0 POMC -0.138 0.193 -9999.0 0.0 -0.686 15.0 15.0 EP300 0.176 0.137 0.291 291.0 -9999.0 0.0 291.0 cortisol/GR alpha (dimer)/p53 0.233 0.261 0.516 193.0 -9999.0 0.0 193.0 proteasomal ubiquitin-dependent protein catabolic process 0.09 0.109 0.265 82.0 -9999.0 0.0 82.0 SGK1 0.23 0.167 0.362 303.0 -0.427 1.0 304.0 IL13 -0.294 0.248 -9999.0 0.0 -0.717 52.0 52.0 IL6 -0.747 0.483 0.622 1.0 -1.029 376.0 377.0 PRKACG 0.033 0.026 -9999.0 0.0 -0.542 1.0 1.0 IL5 -0.243 0.206 -9999.0 0.0 -0.623 39.0 39.0 IL2 -0.42 0.325 -9999.0 0.0 -0.674 276.0 276.0 CDK5 0.032 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PRKACB 0.035 0.083 -9999.0 0.0 -0.542 8.0 8.0 HSP90AA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IL8 -0.237 0.263 0.52 4.0 -0.529 142.0 146.0 CDK5R1/CDK5 0.038 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA/PKAc -0.094 0.177 0.431 3.0 -0.396 31.0 34.0 cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.254 0.253 0.5 222.0 -9999.0 0.0 222.0 SMARCA4 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 chromatin remodeling 0.171 0.16 0.327 212.0 -9999.0 0.0 212.0 NF kappa B1 p50/RelA/Cbp -0.003 0.193 0.475 27.0 -0.341 6.0 33.0 JUN (dimer) -0.209 0.24 0.391 1.0 -0.488 158.0 159.0 YWHAH 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 VIPR1 -0.108 0.165 -9999.0 0.0 -0.559 24.0 24.0 NR3C1 0.187 0.203 0.382 200.0 -0.445 5.0 205.0 NR4A1 0.014 0.125 -9999.0 0.0 -0.546 24.0 24.0 TIF2/SUV420H1 0.039 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade -0.249 0.181 -9999.0 0.0 -0.549 39.0 39.0 cortisol/GR alpha (dimer)/Src-1 0.268 0.266 0.511 237.0 -9999.0 0.0 237.0 PBX1 0.043 0.043 -9999.0 0.0 -9999.0 0.0 0.0 POU1F1 0.039 0.026 -9999.0 0.0 -0.537 1.0 1.0 SELE -0.261 0.348 0.52 4.0 -0.666 144.0 148.0 cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.171 0.16 0.328 212.0 -9999.0 0.0 212.0 cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.254 0.253 0.5 222.0 -9999.0 0.0 222.0 mol:cortisol 0.176 0.174 0.322 251.0 -9999.0 0.0 251.0 MMP1 -0.022 0.348 -9999.0 0.0 -0.942 53.0 53.0