Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.237 0.595 2.0 -0.546 78.0 80.0 IHH 0.021 0.075 0.237 2.0 -0.134 80.0 82.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.313 128.0 128.0 LRPAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.067 0.147 0.311 128.0 -9999.0 0.0 128.0 SMO/beta Arrestin2 -0.001 0.185 0.413 2.0 -0.471 31.0 33.0 SMO -0.016 0.184 0.446 2.0 -0.473 35.0 37.0 AKT1 -0.02 0.191 0.308 1.0 -0.593 37.0 38.0 ARRB2 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.237 -9999.0 0.0 -0.542 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.182 0.444 2.0 -0.466 35.0 37.0 STIL 0.041 0.149 0.342 30.0 -0.329 8.0 38.0 DHH N/PTCH2 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.162 0.381 2.0 -0.32 85.0 87.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.392 0.525 6.0 -0.897 95.0 101.0 determination of left/right symmetry -0.015 0.182 0.444 2.0 -0.466 35.0 37.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.542 47.0 47.0 skeletal system development -0.109 0.387 0.524 6.0 -0.885 95.0 101.0 IHH N/Hhip 0.038 0.053 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.182 0.444 2.0 -0.466 35.0 37.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.059 -9999.0 0.0 -0.542 5.0 5.0 PI3K 0.006 0.127 -9999.0 0.0 -0.399 44.0 44.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.266 -9999.0 0.0 -0.542 158.0 158.0 somite specification -0.015 0.182 0.444 2.0 -0.466 35.0 37.0 SHH Np/Cholesterol/PTCH1 -0.009 0.122 -9999.0 0.0 -0.265 66.0 66.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.311 5.0 5.0 SHH Np/Cholesterol/Megalin -0.055 0.144 -9999.0 0.0 -0.319 110.0 110.0 SHH 0.011 0.043 -9999.0 0.0 -0.399 5.0 5.0 catabolic process -0.009 0.174 0.469 2.0 -0.352 90.0 92.0 SMO/Vitamin D3 0.01 0.171 0.41 15.0 -0.362 31.0 46.0 SHH Np/Cholesterol/Hhip 0.025 0.038 -9999.0 0.0 -0.311 5.0 5.0 LRP2 -0.119 0.254 -9999.0 0.0 -0.542 136.0 136.0 receptor-mediated endocytosis -0.061 0.195 0.349 8.0 -0.486 43.0 51.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.312 87.0 87.0 SHH Np/Cholesterol/CDO 0.02 0.049 -9999.0 0.0 -0.35 7.0 7.0 mesenchymal cell differentiation -0.025 0.038 0.309 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.026 0.158 0.415 16.0 -0.266 66.0 82.0 IHH N/PTCH2 0.038 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.542 3.0 3.0 IHH N/PTCH1 -0.0 0.179 0.471 2.0 -0.351 92.0 94.0 Megalin/LRPAP1 -0.071 0.198 -9999.0 0.0 -0.393 139.0 139.0 PTCH2 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.309 5.0 5.0 PTCH1 -0.009 0.175 0.469 2.0 -0.353 90.0 92.0 HHIP 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0