IL1-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations UBC13/UEV1A 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERC1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.005 0.102 -9999.0 0.0 -0.381 19.0 19.0 IRAK/TOLLIP 0.04 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IKBKB 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IKBKG 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R2 0.055 0.044 0.263 1.0 -0.399 3.0 4.0 IL1A 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IL1B -0.017 0.121 -9999.0 0.0 -0.417 41.0 41.0 IRAK/TRAF6/p62/Atypical PKCs 0.065 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IL1R2 0.039 0.055 -9999.0 0.0 -0.542 3.0 3.0 IL1R1 -0.03 0.183 -9999.0 0.0 -0.542 58.0 58.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.031 0.135 -9999.0 0.0 -0.422 33.0 33.0 TOLLIP 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TICAM2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K3 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB1/TAB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex/ELKS 0.038 0.068 -9999.0 0.0 -0.352 1.0 1.0 JUN -0.049 0.102 0.327 1.0 -0.271 82.0 83.0 MAP3K7 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.025 0.197 -9999.0 0.0 -0.369 112.0 112.0 IL1 alpha/IL1R1/IL1RAP/MYD88 0.04 0.129 -9999.0 0.0 -0.314 58.0 58.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.542 47.0 47.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.053 0.128 -9999.0 0.0 -0.298 57.0 57.0 IL1 beta fragment/IL1R1/IL1RAP -0.023 0.162 -9999.0 0.0 -0.353 91.0 91.0 NFKB1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.009 0.053 0.344 1.0 -0.266 11.0 12.0 IRAK1 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IL1RN/IL1R1 0.015 0.148 -9999.0 0.0 -0.388 58.0 58.0 IRAK4 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI 0.035 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.006 0.127 -9999.0 0.0 -0.399 44.0 44.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.022 0.136 -9999.0 0.0 -0.443 28.0 28.0 CHUK 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.023 0.162 -9999.0 0.0 -0.353 91.0 91.0 IL1 beta/IL1R2 0.007 0.123 -9999.0 0.0 -0.359 44.0 44.0 IRAK/TRAF6/TAK1/TAB1/TAB2 0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.033 0.178 -9999.0 0.0 -0.48 40.0 40.0 IRAK3 0.035 0.033 -9999.0 0.0 -0.542 1.0 1.0 IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.008 0.155 -9999.0 0.0 -0.326 88.0 88.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.001 0.102 -9999.0 0.0 -0.385 12.0 12.0 IL1 alpha/IL1R1/IL1RAP 0.023 0.131 -9999.0 0.0 -0.342 58.0 58.0 RELA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SQSTM1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MYD88 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IRAK/TRAF6/MEKK3 0.054 0.028 -9999.0 0.0 -9999.0 0.0 0.0 IL1RAP 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 UBE2N 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IRAK/TRAF6 -0.023 0.125 -9999.0 0.0 -0.29 82.0 82.0 CASP1 -0.012 0.15 -9999.0 0.0 -0.542 38.0 38.0 IL1RN/IL1R2 0.068 0.057 0.263 6.0 -0.399 3.0 9.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.005 0.163 -9999.0 0.0 -0.338 89.0 89.0 TMEM189-UBE2V1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.005 0.132 -9999.0 0.0 -0.35 57.0 57.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IL1RN 0.055 0.051 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6/TAK1/TAB1/TAB2 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 0.016 0.055 0.357 2.0 -0.276 10.0 12.0