Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Signaling mediated by p38-alpha and p38-beta 250.0 11006.0 44.0 -0.606 0.034 1000.0 -1000.0 -0.002 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 220.0 17214.0 78.0 -1.006 0.324 1000.0 -1000.0 -0.037 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 158.0 10763.0 68.0 -0.88 0.448 1000.0 -1000.0 -0.055 -1000.0 Endothelins 152.0 14593.0 96.0 -0.807 0.169 1000.0 -1000.0 -0.023 -1000.0 EGFR-dependent Endothelin signaling events 146.0 3079.0 21.0 -0.309 0.048 1000.0 -1000.0 -0.035 -1000.0 Class IB PI3K non-lipid kinase events 126.0 378.0 3.0 -0.108 -1000.0 1000.0 -1000.0 -0.024 -1000.0 IGF1 pathway 117.0 6689.0 57.0 -0.265 0.109 1000.0 -1000.0 -0.029 -1000.0 FOXM1 transcription factor network 115.0 5878.0 51.0 -0.122 0.709 1000.0 -1000.0 0.011 -1000.0 Arf6 signaling events 102.0 6385.0 62.0 -0.309 0.082 1000.0 -1000.0 -0.003 -1000.0 Nongenotropic Androgen signaling 96.0 5027.0 52.0 -0.567 0.295 1000.0 -1000.0 -0.019 -1000.0 Glucocorticoid receptor regulatory network 86.0 9912.0 114.0 -0.946 0.291 1000.0 -1000.0 -0.051 -1000.0 S1P1 pathway 78.0 2829.0 36.0 -0.62 0.046 1000.0 -1000.0 -0.018 -1000.0 HIF-1-alpha transcription factor network 74.0 5642.0 76.0 -0.4 0.07 1000.0 -1000.0 -0.008 -1000.0 Calcium signaling in the CD4+ TCR pathway 72.0 2245.0 31.0 -0.352 0.041 1000.0 -1000.0 -0.021 -1000.0 Signaling events mediated by PTP1B 71.0 5401.0 76.0 -0.367 0.189 1000.0 -1000.0 -0.036 -1000.0 PDGFR-alpha signaling pathway 71.0 3127.0 44.0 -0.699 0.063 1000.0 -1000.0 -0.018 -1000.0 Ephrin B reverse signaling 69.0 3334.0 48.0 -0.179 0.06 1000.0 -1000.0 -0.033 -1000.0 BMP receptor signaling 67.0 5492.0 81.0 -0.4 0.114 1000.0 -1000.0 -0.032 -1000.0 Plasma membrane estrogen receptor signaling 60.0 5210.0 86.0 -0.249 0.178 1000.0 -1000.0 -0.043 -1000.0 E-cadherin signaling in keratinocytes 57.0 2477.0 43.0 -0.269 0.036 1000.0 -1000.0 -0.013 -1000.0 Ras signaling in the CD4+ TCR pathway 57.0 982.0 17.0 -0.198 0.034 1000.0 -1000.0 -0.01 -1000.0 IL23-mediated signaling events 56.0 3379.0 60.0 -0.793 0.065 1000.0 -1000.0 -0.004 -1000.0 IL6-mediated signaling events 55.0 4195.0 75.0 -0.366 0.074 1000.0 -1000.0 -0.037 -1000.0 IL4-mediated signaling events 54.0 4933.0 91.0 -0.509 0.133 1000.0 -1000.0 -0.109 -1000.0 FAS signaling pathway (CD95) 53.0 2535.0 47.0 -0.878 0.06 1000.0 -1000.0 -0.025 -1000.0 Integrins in angiogenesis 53.0 4508.0 84.0 -0.393 0.136 1000.0 -1000.0 -0.025 -1000.0 EPHB forward signaling 52.0 4498.0 85.0 -0.18 0.144 1000.0 -1000.0 -0.056 -1000.0 PLK1 signaling events 49.0 4205.0 85.0 -0.036 0.174 1000.0 -1000.0 -0.025 -1000.0 Visual signal transduction: Rods 47.0 2470.0 52.0 -0.429 0.074 1000.0 -1000.0 -0.014 -1000.0 Signaling events mediated by the Hedgehog family 46.0 2396.0 52.0 -0.144 0.067 1000.0 -1000.0 -0.013 -1000.0 Fc-epsilon receptor I signaling in mast cells 46.0 4484.0 97.0 -0.353 0.041 1000.0 -1000.0 -0.043 -1000.0 Aurora B signaling 45.0 3049.0 67.0 -0.383 0.238 1000.0 -1000.0 -0.029 -1000.0 Glypican 1 network 41.0 1996.0 48.0 -0.393 0.071 1000.0 -1000.0 -0.017 -1000.0 S1P5 pathway 39.0 669.0 17.0 -0.171 0.066 1000.0 -1000.0 -0.005 -1000.0 Insulin Pathway 39.0 2899.0 74.0 -0.277 0.091 1000.0 -1000.0 -0.032 -1000.0 p75(NTR)-mediated signaling 38.0 4789.0 125.0 -0.128 0.095 1000.0 -1000.0 -0.042 -1000.0 PLK2 and PLK4 events 36.0 108.0 3.0 0.016 0.056 1000.0 -1000.0 0.006 -1000.0 Presenilin action in Notch and Wnt signaling 36.0 2231.0 61.0 -0.382 0.108 1000.0 -1000.0 -0.032 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 36.0 2734.0 74.0 -0.269 0.074 1000.0 -1000.0 -0.053 -1000.0 TCGA08_retinoblastoma 36.0 290.0 8.0 -0.022 0.058 1000.0 -1000.0 -0.006 -1000.0 Nectin adhesion pathway 34.0 2193.0 63.0 -0.077 0.054 1000.0 -1000.0 -0.035 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 33.0 2826.0 85.0 -0.541 0.043 1000.0 -1000.0 -0.029 -1000.0 IL27-mediated signaling events 33.0 1706.0 51.0 -0.372 0.067 1000.0 -1000.0 -0.034 -1000.0 LPA receptor mediated events 32.0 3365.0 102.0 -0.353 0.096 1000.0 -1000.0 -0.055 -1000.0 S1P4 pathway 32.0 821.0 25.0 -0.171 0.046 1000.0 -1000.0 -0.014 -1000.0 ErbB2/ErbB3 signaling events 31.0 2015.0 65.0 -0.346 0.047 1000.0 -1000.0 -0.039 -1000.0 Syndecan-1-mediated signaling events 31.0 1078.0 34.0 -0.041 0.116 1000.0 -1000.0 -0.015 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 31.0 3776.0 120.0 -0.245 0.118 1000.0 -1000.0 -0.039 -1000.0 ErbB4 signaling events 29.0 2042.0 69.0 -0.362 0.138 1000.0 -1000.0 -0.012 -1000.0 amb2 Integrin signaling 29.0 2400.0 82.0 -0.525 0.136 1000.0 -1000.0 -0.02 -1000.0 TCGA08_rtk_signaling 28.0 748.0 26.0 -0.269 0.043 1000.0 -1000.0 -0.021 -1000.0 Regulation of nuclear SMAD2/3 signaling 27.0 3677.0 136.0 -0.365 0.075 1000.0 -1000.0 -0.039 -1000.0 FOXA2 and FOXA3 transcription factor networks 27.0 1285.0 46.0 -0.743 0.051 1000.0 -1000.0 -0.008 -1000.0 TCR signaling in naïve CD8+ T cells 27.0 2601.0 93.0 -0.039 0.083 1000.0 -1000.0 -0.042 -1000.0 Canonical Wnt signaling pathway 27.0 1419.0 51.0 -0.382 0.163 1000.0 -1000.0 -0.034 -1000.0 Signaling events regulated by Ret tyrosine kinase 26.0 2209.0 82.0 -0.1 0.117 1000.0 -1000.0 -0.053 -1000.0 IL12-mediated signaling events 25.0 2201.0 87.0 -0.83 0.088 1000.0 -1000.0 -0.037 -1000.0 Syndecan-2-mediated signaling events 25.0 1729.0 69.0 -0.324 0.136 1000.0 -1000.0 -0.028 -1000.0 Syndecan-3-mediated signaling events 25.0 877.0 35.0 -0.364 0.076 1000.0 -1000.0 -0.021 -1000.0 Thromboxane A2 receptor signaling 24.0 2623.0 105.0 -0.269 0.067 1000.0 -1000.0 -0.032 -1000.0 mTOR signaling pathway 24.0 1292.0 53.0 -0.051 0.044 1000.0 -1000.0 -0.03 -1000.0 HIF-2-alpha transcription factor network 24.0 1041.0 43.0 -0.227 0.258 1000.0 -1000.0 -0.108 -1000.0 S1P3 pathway 24.0 1024.0 42.0 -0.17 0.063 1000.0 -1000.0 -0.024 -1000.0 Angiopoietin receptor Tie2-mediated signaling 24.0 2116.0 88.0 -0.393 0.136 1000.0 -1000.0 -0.059 -1000.0 Reelin signaling pathway 23.0 1337.0 56.0 -0.056 0.083 1000.0 -1000.0 -0.021 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 23.0 1196.0 52.0 -0.379 0.107 1000.0 -1000.0 -0.012 -1000.0 Syndecan-4-mediated signaling events 23.0 1542.0 67.0 -0.393 0.152 1000.0 -1000.0 -0.026 -1000.0 Regulation of Androgen receptor activity 23.0 1611.0 70.0 -0.431 0.08 1000.0 -1000.0 -0.032 -1000.0 Osteopontin-mediated events 22.0 848.0 38.0 -0.352 0.134 1000.0 -1000.0 -0.01 -1000.0 Ceramide signaling pathway 22.0 1740.0 76.0 -0.249 0.083 1000.0 -1000.0 -0.019 -1000.0 IL1-mediated signaling events 22.0 1370.0 62.0 -0.049 0.068 1000.0 -1000.0 -0.021 -1000.0 Coregulation of Androgen receptor activity 21.0 1658.0 76.0 -0.228 0.054 1000.0 -1000.0 -0.019 -1000.0 Regulation of p38-alpha and p38-beta 21.0 1147.0 54.0 -0.312 0.072 1000.0 -1000.0 -0.038 -1000.0 Regulation of Telomerase 20.0 2124.0 102.0 -0.351 0.088 1000.0 -1000.0 -0.013 -1000.0 TCGA08_p53 18.0 129.0 7.0 -0.01 0.029 1000.0 -1000.0 -0.002 -1000.0 Signaling mediated by p38-gamma and p38-delta 18.0 276.0 15.0 -0.006 0.035 1000.0 -1000.0 -0.025 -1000.0 E-cadherin signaling in the nascent adherens junction 18.0 1401.0 76.0 -0.04 0.059 1000.0 -1000.0 -0.044 -1000.0 Noncanonical Wnt signaling pathway 16.0 430.0 26.0 -0.016 0.041 1000.0 -1000.0 -0.031 -1000.0 IL2 signaling events mediated by PI3K 16.0 939.0 58.0 -0.118 0.049 1000.0 -1000.0 -0.027 -1000.0 Cellular roles of Anthrax toxin 15.0 616.0 39.0 -0.063 0.038 1000.0 -1000.0 -0.014 -1000.0 Hedgehog signaling events mediated by Gli proteins 15.0 1016.0 65.0 -0.171 0.078 1000.0 -1000.0 -0.033 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 15.0 711.0 45.0 -0.006 0.059 1000.0 -1000.0 -0.019 -1000.0 Signaling events mediated by PRL 15.0 535.0 34.0 -0.308 0.052 1000.0 -1000.0 -0.025 -1000.0 E-cadherin signaling events 15.0 77.0 5.0 0.007 0.035 1000.0 -1000.0 0.019 -1000.0 Caspase cascade in apoptosis 13.0 1023.0 74.0 -0.154 0.049 1000.0 -1000.0 -0.023 -1000.0 ceramide signaling pathway 13.0 638.0 49.0 -0.069 0.053 1000.0 -1000.0 -0.015 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 13.0 1650.0 125.0 -0.375 0.075 1000.0 -1000.0 -0.027 -1000.0 Wnt signaling 13.0 92.0 7.0 -0.016 0.041 1000.0 -1000.0 -0.022 -1000.0 BCR signaling pathway 13.0 1288.0 99.0 -0.145 0.093 1000.0 -1000.0 -0.042 -1000.0 VEGFR1 specific signals 13.0 768.0 56.0 -0.375 0.076 1000.0 -1000.0 -0.03 -1000.0 IFN-gamma pathway 11.0 805.0 68.0 -0.02 0.101 1000.0 -1000.0 -0.038 -1000.0 FoxO family signaling 11.0 747.0 64.0 0.0 0.148 1000.0 -1000.0 -0.02 -1000.0 Sphingosine 1-phosphate (S1P) pathway 10.0 281.0 28.0 -0.171 0.054 1000.0 -1000.0 -0.013 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 10.0 562.0 54.0 -0.04 0.084 1000.0 -1000.0 -0.024 -1000.0 EPO signaling pathway 10.0 564.0 55.0 -0.089 0.069 1000.0 -1000.0 -0.014 -1000.0 JNK signaling in the CD4+ TCR pathway 9.0 154.0 17.0 -0.04 0.091 1000.0 -1000.0 -0.023 -1000.0 Arf6 downstream pathway 9.0 397.0 43.0 -0.092 0.093 1000.0 -1000.0 -0.031 -1000.0 Class I PI3K signaling events mediated by Akt 9.0 639.0 68.0 -0.147 0.062 1000.0 -1000.0 -0.025 -1000.0 Signaling events mediated by HDAC Class III 8.0 326.0 40.0 -0.062 0.063 1000.0 -1000.0 -0.032 -1000.0 TRAIL signaling pathway 8.0 417.0 48.0 -0.002 0.047 1000.0 -1000.0 -0.012 -1000.0 Signaling events mediated by HDAC Class II 7.0 565.0 75.0 -0.058 0.067 1000.0 -1000.0 -0.029 -1000.0 Circadian rhythm pathway 7.0 171.0 22.0 -0.021 0.106 1000.0 -1000.0 -0.018 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 7.0 273.0 37.0 -0.02 0.085 1000.0 -1000.0 -0.015 -1000.0 PDGFR-beta signaling pathway 7.0 702.0 97.0 -0.035 0.081 1000.0 -1000.0 -0.037 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 6.0 575.0 83.0 -0.069 0.066 1000.0 -1000.0 -0.007 -1000.0 Retinoic acid receptors-mediated signaling 6.0 376.0 58.0 -0.054 0.081 1000.0 -1000.0 -0.023 -1000.0 Paxillin-dependent events mediated by a4b1 6.0 235.0 36.0 -0.071 0.076 1000.0 -1000.0 -0.036 -1000.0 Arf6 trafficking events 6.0 487.0 71.0 -0.253 0.056 1000.0 -1000.0 -0.027 -1000.0 p38 MAPK signaling pathway 6.0 294.0 44.0 -0.016 0.067 1000.0 -1000.0 -0.013 -1000.0 Visual signal transduction: Cones 5.0 192.0 38.0 -0.0 0.071 1000.0 -1000.0 -0.0 -1000.0 Insulin-mediated glucose transport 5.0 182.0 32.0 -0.1 0.053 1000.0 -1000.0 -0.011 -1000.0 Class I PI3K signaling events 5.0 414.0 73.0 -0.009 0.059 1000.0 -1000.0 -0.021 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 4.0 161.0 34.0 -0.048 0.084 1000.0 -1000.0 -0.023 -1000.0 Canonical NF-kappaB pathway 4.0 180.0 39.0 0.0 0.072 1000.0 -1000.0 -0.016 -1000.0 Signaling events mediated by HDAC Class I 4.0 492.0 104.0 -0.208 0.082 1000.0 -1000.0 -0.042 -1000.0 Atypical NF-kappaB pathway 4.0 147.0 31.0 -0.02 0.049 1000.0 -1000.0 -0.001 -1000.0 IL2 signaling events mediated by STAT5 4.0 91.0 22.0 -0.019 0.082 1000.0 -1000.0 -0.021 -1000.0 Aurora C signaling 3.0 23.0 7.0 -0.0 0.079 1000.0 -1000.0 -0.012 -1000.0 Effects of Botulinum toxin 3.0 83.0 26.0 -0.0 0.071 1000.0 -1000.0 -0.0 -1000.0 LPA4-mediated signaling events 2.0 28.0 12.0 -0.01 0.035 1000.0 -1000.0 -0.017 -1000.0 Aurora A signaling 2.0 179.0 60.0 -0.0 0.118 1000.0 -1000.0 -0.006 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 1.0 26.0 23.0 -0.007 0.066 1000.0 -1000.0 -0.01 -1000.0 BARD1 signaling events 1.0 59.0 57.0 -0.075 0.126 1000.0 -1000.0 -0.042 -1000.0 Ephrin A reverse signaling 1.0 7.0 7.0 0.0 0.044 1000.0 -1000.0 -0.0 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 1.0 57.0 33.0 -0.0 0.077 1000.0 -1000.0 -0.013 -1000.0 Rapid glucocorticoid signaling 1.0 25.0 20.0 -0.0 0.044 1000.0 -1000.0 -0.0 -1000.0 Arf1 pathway 1.0 59.0 54.0 -0.001 0.062 1000.0 -1000.0 -0.01 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 0.0 5.0 0.034 0.054 1000.0 -1000.0 0.019 -1000.0 Glypican 2 network 0.0 0.0 4.0 0.0 0.032 1000.0 -1000.0 0.0 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 25.0 27.0 -0.0 0.078 1000.0 -1000.0 -0.025 -1000.0 Alternative NF-kappaB pathway 0.0 3.0 13.0 0.0 0.096 1000.0 -1000.0 0.0 -1000.0 Total 4436 268260 7203 -29.6896125501 -987.760200246 131000 -131000 -3.14790342315 -131000