Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.141 0.257 -9999.0 0.0 -0.616 39.0 39.0 IHH -0.049 0.113 -9999.0 0.0 -0.275 29.0 29.0 SHH Np/Cholesterol/GAS1 -0.028 0.11 -9999.0 0.0 -0.329 19.0 19.0 LRPAP1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.028 0.109 0.327 19.0 -9999.0 0.0 19.0 SMO/beta Arrestin2 -0.115 0.208 -9999.0 0.0 -0.476 33.0 33.0 SMO -0.124 0.208 -9999.0 0.0 -0.506 31.0 31.0 AKT1 -0.055 0.147 -9999.0 0.0 -0.632 8.0 8.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.11 -9999.0 0.0 -0.335 18.0 18.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.12 0.206 -9999.0 0.0 -0.498 31.0 31.0 STIL -0.082 0.161 -9999.0 0.0 -0.392 26.0 26.0 DHH N/PTCH2 0.009 0.104 -9999.0 0.0 -0.37 11.0 11.0 DHH N/PTCH1 -0.082 0.166 -9999.0 0.0 -0.354 41.0 41.0 PIK3CA 0.014 0.04 -9999.0 0.0 -0.522 1.0 1.0 DHH 0.008 0.083 -9999.0 0.0 -0.402 7.0 7.0 PTHLH -0.214 0.383 -9999.0 0.0 -0.905 43.0 43.0 determination of left/right symmetry -0.12 0.206 -9999.0 0.0 -0.498 31.0 31.0 PIK3R1 0.015 0.066 -9999.0 0.0 -0.335 6.0 6.0 skeletal system development -0.211 0.377 -9999.0 0.0 -0.892 43.0 43.0 IHH N/Hhip -0.033 0.101 -9999.0 0.0 -0.242 28.0 28.0 DHH N/Hhip 0.003 0.091 -9999.0 0.0 -0.327 8.0 8.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.12 0.206 -9999.0 0.0 -0.498 31.0 31.0 pancreas development -0.016 0.084 -9999.0 0.0 -0.243 23.0 23.0 HHAT 0.017 0.067 -9999.0 0.0 -0.522 3.0 3.0 PI3K 0.016 0.056 -9999.0 0.0 -0.293 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.015 0.131 -9999.0 0.0 -0.375 21.0 21.0 somite specification -0.12 0.206 -9999.0 0.0 -0.498 31.0 31.0 SHH Np/Cholesterol/PTCH1 -0.091 0.16 -9999.0 0.0 -0.405 27.0 27.0 SHH Np/Cholesterol/PTCH2 -0.019 0.095 -9999.0 0.0 -0.285 18.0 18.0 SHH Np/Cholesterol/Megalin -0.02 0.088 -9999.0 0.0 -0.276 14.0 14.0 SHH -0.031 0.096 0.224 1.0 -0.382 10.0 11.0 catabolic process -0.091 0.173 -9999.0 0.0 -0.385 40.0 40.0 SMO/Vitamin D3 -0.102 0.189 -9999.0 0.0 -0.473 27.0 27.0 SHH Np/Cholesterol/Hhip -0.026 0.09 -9999.0 0.0 -0.27 17.0 17.0 LRP2 -0.009 0.081 -9999.0 0.0 -0.242 21.0 21.0 receptor-mediated endocytosis -0.106 0.181 -9999.0 0.0 -0.459 29.0 29.0 SHH Np/Cholesterol/BOC -0.025 0.092 -9999.0 0.0 -0.319 12.0 12.0 SHH Np/Cholesterol/CDO -0.013 0.085 -9999.0 0.0 -0.304 12.0 12.0 mesenchymal cell differentiation 0.026 0.089 0.268 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.081 0.17 -9999.0 0.0 -0.406 27.0 27.0 IHH N/PTCH2 -0.029 0.111 -9999.0 0.0 -0.298 21.0 21.0 CDON 0.015 0.058 -9999.0 0.0 -0.428 3.0 3.0 IHH N/PTCH1 -0.076 0.182 -9999.0 0.0 -0.382 42.0 42.0 Megalin/LRPAP1 0.014 0.061 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.0 0.104 -9999.0 0.0 -0.371 13.0 13.0 SHH Np/Cholesterol -0.015 0.075 -9999.0 0.0 -0.294 10.0 10.0 PTCH1 -0.091 0.173 -9999.0 0.0 -0.386 40.0 40.0 HHIP -0.016 0.084 -9999.0 0.0 -0.244 23.0 23.0