Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.04 -9999.0 0.0 -0.289 3.0 3.0 epithelial cell differentiation 0.048 0.031 -9999.0 0.0 -0.277 1.0 1.0 CYFIP2 0.014 0.068 -9999.0 0.0 -0.322 7.0 7.0 ENAH 0.023 0.086 0.278 4.0 -0.342 1.0 5.0 EGFR -0.012 0.14 -9999.0 0.0 -0.522 14.0 14.0 EPHA2 0.005 0.107 -9999.0 0.0 -0.522 8.0 8.0 MYO6 0.014 0.028 -9999.0 0.0 -0.267 1.0 1.0 CTNNB1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.052 -9999.0 0.0 -0.325 2.0 2.0 AQP5 -0.133 0.213 -9999.0 0.0 -0.463 57.0 57.0 CTNND1 0.024 0.039 -9999.0 0.0 -0.522 1.0 1.0 mol:PI-4-5-P2 0.014 0.028 -9999.0 0.0 -0.264 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.067 -9999.0 0.0 -0.26 8.0 8.0 EGF -0.031 0.138 -9999.0 0.0 -0.335 30.0 30.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.057 0.171 -9999.0 0.0 -0.459 30.0 30.0 cortical microtubule organization 0.048 0.031 -9999.0 0.0 -0.277 1.0 1.0 GO:0000145 -0.004 0.028 -9999.0 0.0 -0.252 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.033 -9999.0 0.0 -0.28 1.0 1.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.016 0.047 -9999.0 0.0 -0.46 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.035 0.069 -9999.0 0.0 -0.297 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.014 0.029 -9999.0 0.0 -0.267 1.0 1.0 ARF6/GTP 0.039 0.065 -9999.0 0.0 -0.278 5.0 5.0 CDH1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.006 0.109 -9999.0 0.0 -0.275 23.0 23.0 RhoA/GDP 0.049 0.031 -9999.0 0.0 -0.265 1.0 1.0 actin cytoskeleton organization -0.005 0.028 -9999.0 0.0 -0.262 1.0 1.0 IGF-1R heterotetramer 0.021 0.055 -9999.0 0.0 -0.521 2.0 2.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.021 0.055 -9999.0 0.0 -0.522 2.0 2.0 IGF1 -0.072 0.198 -9999.0 0.0 -0.426 44.0 44.0 DIAPH1 -0.011 0.159 -9999.0 0.0 -0.577 7.0 7.0 Wnt receptor signaling pathway -0.048 0.031 0.277 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.017 0.049 -9999.0 0.0 -0.46 1.0 1.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.005 0.028 -9999.0 0.0 -0.268 1.0 1.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.005 0.03 0.171 1.0 -0.261 2.0 3.0 Ephrin A1/EPHA2 0.028 0.071 -9999.0 0.0 -0.294 8.0 8.0 SEC6/SEC8 0.009 0.02 -9999.0 0.0 -0.25 1.0 1.0 MGAT3 -0.012 0.068 -9999.0 0.0 -0.264 8.0 8.0 HGF/MET 0.013 0.093 -9999.0 0.0 -0.276 16.0 16.0 HGF -0.005 0.115 -9999.0 0.0 -0.402 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.04 -9999.0 0.0 -0.291 3.0 3.0 actin cable formation 0.071 0.128 0.241 54.0 -9999.0 0.0 54.0 KIAA1543 -0.01 0.046 0.166 3.0 -0.258 5.0 8.0 KIFC3 0.007 0.046 -9999.0 0.0 -0.27 5.0 5.0 NCK1 0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.014 0.028 -9999.0 0.0 -0.267 1.0 1.0 NCK1/GIT1 0.029 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.031 -9999.0 0.0 -0.277 1.0 1.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.014 0.026 -9999.0 0.0 -0.267 1.0 1.0 PIP5K1C 0.014 0.029 -9999.0 0.0 -0.267 1.0 1.0 LIMA1 0.021 0.055 -9999.0 0.0 -0.522 2.0 2.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.041 0.106 0.316 9.0 -0.404 1.0 10.0 adherens junction assembly -0.02 0.117 0.277 2.0 -0.474 9.0 11.0 IGF-1R heterotetramer/IGF1 -0.011 0.114 -9999.0 0.0 -0.27 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.004 0.107 -9999.0 0.0 -0.522 8.0 8.0 PLEKHA7 0.008 0.05 -9999.0 0.0 -0.27 5.0 5.0 mol:GTP 0.033 0.067 -9999.0 0.0 -0.295 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.032 0.085 0.324 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.018 0.04 -9999.0 0.0 -0.289 3.0 3.0 regulation of cell-cell adhesion -0.005 0.028 -9999.0 0.0 -0.262 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.04 -9999.0 0.0 -0.291 3.0 3.0