Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.091 0.198 0.45 46.0 -9999.0 0.0 46.0 KIRREL -0.093 0.231 -9999.0 0.0 -0.61 34.0 34.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.091 0.198 -9999.0 0.0 -0.451 46.0 46.0 PLCG1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.074 0.142 -9999.0 0.0 -0.375 26.0 26.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.033 0.118 -9999.0 0.0 -0.305 26.0 26.0 FYN -0.061 0.146 -9999.0 0.0 -0.365 26.0 26.0 mol:Ca2+ -0.074 0.141 -9999.0 0.0 -0.372 26.0 26.0 mol:DAG -0.074 0.142 -9999.0 0.0 -0.374 26.0 26.0 NPHS2 -0.011 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.074 0.142 -9999.0 0.0 -0.374 26.0 26.0 regulation of endocytosis -0.051 0.138 -9999.0 0.0 -0.338 26.0 26.0 Nephrin/NEPH1/podocin/Cholesterol -0.076 0.146 -9999.0 0.0 -0.336 46.0 46.0 establishment of cell polarity -0.091 0.198 -9999.0 0.0 -0.45 46.0 46.0 Nephrin/NEPH1/podocin/NCK1-2 -0.045 0.139 -9999.0 0.0 -0.524 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 -0.051 0.14 -9999.0 0.0 -0.343 26.0 26.0 NPHS1 -0.043 0.143 -9999.0 0.0 -0.547 15.0 15.0 Nephrin/NEPH1/podocin -0.062 0.146 -9999.0 0.0 -0.367 26.0 26.0 TJP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.074 0.142 -9999.0 0.0 -0.375 26.0 26.0 CD2AP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.074 0.142 -9999.0 0.0 -0.375 26.0 26.0 GRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.075 0.16 -9999.0 0.0 -0.37 30.0 30.0 cytoskeleton organization -0.038 0.14 -9999.0 0.0 -0.373 17.0 17.0 Nephrin/NEPH1 -0.064 0.144 -9999.0 0.0 -0.323 46.0 46.0 Nephrin/NEPH1/ZO-1 -0.08 0.154 -9999.0 0.0 -0.396 28.0 28.0