Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.213 0.335 -9999.0 0.0 -0.689 54.0 54.0 IHH -0.104 0.202 -9999.0 0.0 -0.569 30.0 30.0 SHH Np/Cholesterol/GAS1 -0.065 0.166 -9999.0 0.0 -0.354 47.0 47.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.065 0.165 0.352 47.0 -9999.0 0.0 47.0 SMO/beta Arrestin2 -0.14 0.226 -9999.0 0.0 -0.594 27.0 27.0 SMO -0.154 0.238 -9999.0 0.0 -0.587 33.0 33.0 AKT1 -0.062 0.129 -9999.0 0.0 -0.449 8.0 8.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.051 0.181 -9999.0 0.0 -0.561 23.0 23.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.151 0.234 -9999.0 0.0 -0.57 34.0 34.0 STIL -0.127 0.225 -9999.0 0.0 -0.549 33.0 33.0 DHH N/PTCH2 -0.024 0.136 -9999.0 0.0 -0.439 19.0 19.0 DHH N/PTCH1 -0.125 0.209 -9999.0 0.0 -0.564 24.0 24.0 PIK3CA 0.01 0.044 -9999.0 0.0 -0.622 1.0 1.0 DHH -0.009 0.109 -9999.0 0.0 -0.587 7.0 7.0 PTHLH -0.292 0.45 -9999.0 0.0 -0.985 51.0 51.0 determination of left/right symmetry -0.151 0.234 -9999.0 0.0 -0.57 34.0 34.0 PIK3R1 -0.01 0.113 -9999.0 0.0 -0.571 8.0 8.0 skeletal system development -0.287 0.441 -9999.0 0.0 -0.968 51.0 51.0 IHH N/Hhip -0.095 0.201 -9999.0 0.0 -0.473 41.0 41.0 DHH N/Hhip -0.043 0.156 -9999.0 0.0 -0.432 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.151 0.234 -9999.0 0.0 -0.57 34.0 34.0 pancreas development -0.052 0.173 -9999.0 0.0 -0.539 23.0 23.0 HHAT 0.003 0.076 -9999.0 0.0 -0.622 3.0 3.0 PI3K -0.0 0.089 -9999.0 0.0 -0.416 9.0 9.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.048 0.179 -9999.0 0.0 -0.579 21.0 21.0 somite specification -0.151 0.234 -9999.0 0.0 -0.57 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.14 0.237 -9999.0 0.0 -0.578 34.0 34.0 SHH Np/Cholesterol/PTCH2 -0.053 0.15 -9999.0 0.0 -0.344 41.0 41.0 SHH Np/Cholesterol/Megalin -0.069 0.159 -9999.0 0.0 -0.341 49.0 49.0 SHH -0.05 0.155 -9999.0 0.0 -0.41 32.0 32.0 catabolic process -0.134 0.222 -9999.0 0.0 -0.58 26.0 26.0 SMO/Vitamin D3 -0.154 0.242 -9999.0 0.0 -0.626 30.0 30.0 SHH Np/Cholesterol/Hhip -0.07 0.165 -9999.0 0.0 -0.362 46.0 46.0 LRP2 -0.052 0.174 -9999.0 0.0 -0.543 23.0 23.0 receptor-mediated endocytosis -0.165 0.231 -9999.0 0.0 -0.592 33.0 33.0 SHH Np/Cholesterol/BOC -0.068 0.153 -9999.0 0.0 -0.321 53.0 53.0 SHH Np/Cholesterol/CDO -0.037 0.129 -9999.0 0.0 -0.322 34.0 34.0 mesenchymal cell differentiation 0.07 0.164 0.36 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.139 0.239 -9999.0 0.0 -0.58 34.0 34.0 IHH N/PTCH2 -0.076 0.178 -9999.0 0.0 -0.419 38.0 38.0 CDON 0.004 0.073 -9999.0 0.0 -0.595 3.0 3.0 IHH N/PTCH1 -0.135 0.225 -9999.0 0.0 -0.586 26.0 26.0 Megalin/LRPAP1 -0.028 0.128 -9999.0 0.0 -0.388 23.0 23.0 PTCH2 -0.025 0.144 -9999.0 0.0 -0.578 13.0 13.0 SHH Np/Cholesterol -0.046 0.117 -9999.0 0.0 -0.318 32.0 32.0 PTCH1 -0.134 0.223 -9999.0 0.0 -0.582 26.0 26.0 HHIP -0.052 0.173 -9999.0 0.0 -0.54 23.0 23.0