Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.025 0.035 -9999.0 0.0 -0.266 3.0 3.0 epithelial cell differentiation -0.002 0.022 -9999.0 0.0 -0.32 1.0 1.0 CYFIP2 -0.013 0.121 -9999.0 0.0 -0.576 9.0 9.0 ENAH 0.048 0.059 -9999.0 0.0 -0.368 1.0 1.0 EGFR -0.033 0.164 -9999.0 0.0 -0.617 15.0 15.0 EPHA2 -0.012 0.123 -9999.0 0.0 -0.622 8.0 8.0 MYO6 0.034 0.023 -9999.0 0.0 -0.3 1.0 1.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.01 0.077 -9999.0 0.0 -0.348 9.0 9.0 AQP5 -0.187 0.201 -9999.0 0.0 -0.481 61.0 61.0 CTNND1 0.01 0.044 -9999.0 0.0 -0.622 1.0 1.0 mol:PI-4-5-P2 0.034 0.023 -9999.0 0.0 -0.296 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.112 -9999.0 0.0 -0.3 9.0 9.0 EGF -0.081 0.213 -9999.0 0.0 -0.567 33.0 33.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.078 0.175 -9999.0 0.0 -0.488 31.0 31.0 cortical microtubule organization -0.002 0.022 -9999.0 0.0 -0.32 1.0 1.0 GO:0000145 0.032 0.022 -9999.0 0.0 -0.283 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.028 0.025 -9999.0 0.0 -0.323 1.0 1.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.011 0.057 -9999.0 0.0 -0.52 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.018 0.072 -9999.0 0.0 -0.342 8.0 8.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.043 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.038 -9999.0 0.0 -0.54 1.0 1.0 ZYX 0.034 0.023 -9999.0 0.0 -0.3 1.0 1.0 ARF6/GTP -0.012 0.06 -9999.0 0.0 -0.312 8.0 8.0 CDH1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.063 0.12 -9999.0 0.0 -0.574 2.0 2.0 RhoA/GDP -0.001 0.021 -9999.0 0.0 -0.297 1.0 1.0 actin cytoskeleton organization 0.038 0.031 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.001 0.085 -9999.0 0.0 -0.601 4.0 4.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.001 0.085 -9999.0 0.0 -0.601 4.0 4.0 IGF1 -0.117 0.249 -9999.0 0.0 -0.594 44.0 44.0 DIAPH1 -0.015 0.083 -9999.0 0.0 -0.592 4.0 4.0 Wnt receptor signaling pathway 0.002 0.022 0.32 1.0 -9999.0 0.0 1.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.011 0.057 -9999.0 0.0 -0.521 1.0 1.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.038 0.032 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.038 0.032 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.013 0.066 -9999.0 0.0 -0.598 1.0 1.0 SEC6/SEC8 -0.002 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.017 0.114 -9999.0 0.0 -0.304 9.0 9.0 HGF/MET -0.035 0.097 -9999.0 0.0 -0.598 1.0 1.0 HGF -0.038 0.167 -9999.0 0.0 -0.593 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.025 0.036 -9999.0 0.0 -0.267 3.0 3.0 actin cable formation 0.062 0.051 -9999.0 0.0 -0.297 1.0 1.0 KIAA1543 0.018 0.09 -9999.0 0.0 -0.599 1.0 1.0 KIFC3 0.026 0.057 -9999.0 0.0 -0.304 6.0 6.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.034 0.023 -9999.0 0.0 -0.3 1.0 1.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.022 -9999.0 0.0 -0.32 1.0 1.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.034 0.023 -9999.0 0.0 -0.3 1.0 1.0 PIP5K1C 0.034 0.023 -9999.0 0.0 -0.3 1.0 1.0 LIMA1 0.006 0.062 -9999.0 0.0 -0.622 2.0 2.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.047 0.06 -9999.0 0.0 -0.446 1.0 1.0 adherens junction assembly 0.022 0.113 -9999.0 0.0 -0.54 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.064 0.12 -9999.0 0.0 -0.602 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.028 -9999.0 0.0 -0.385 1.0 1.0 MET -0.012 0.123 -9999.0 0.0 -0.622 8.0 8.0 PLEKHA7 0.026 0.056 -9999.0 0.0 -0.304 5.0 5.0 mol:GTP 0.017 0.072 -9999.0 0.0 -0.34 8.0 8.0 establishment of epithelial cell apical/basal polarity 0.055 0.027 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.025 0.035 -9999.0 0.0 -0.266 3.0 3.0 regulation of cell-cell adhesion 0.038 0.031 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.025 0.036 -9999.0 0.0 -0.267 3.0 3.0