Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	41.0	2493.0	60.0	-0.672	0.013	1000.0	-1000.0	-0.169	-1000.0
HIF-1-alpha transcription factor network	32.0	2458.0	76.0	-0.58	0.02	1000.0	-1000.0	-0.167	-1000.0
Signaling mediated by p38-alpha and p38-beta	32.0	1444.0	44.0	-0.23	0.013	1000.0	-1000.0	-0.046	-1000.0
IL4-mediated signaling events	31.0	2845.0	91.0	-0.807	0.691	1000.0	-1000.0	-0.157	-1000.0
p75(NTR)-mediated signaling	27.0	3460.0	125.0	-0.247	0.034	1000.0	-1000.0	-0.102	-1000.0
Signaling events mediated by the Hedgehog family	26.0	1388.0	52.0	-0.292	0.07	1000.0	-1000.0	-0.053	-1000.0
Syndecan-1-mediated signaling events	23.0	793.0	34.0	-0.179	0.013	1000.0	-1000.0	-0.05	-1000.0
BMP receptor signaling	22.0	1792.0	81.0	-0.256	0.026	1000.0	-1000.0	-0.088	-1000.0
Glypican 1 network	21.0	1043.0	48.0	-0.162	0.023	1000.0	-1000.0	-0.043	-1000.0
Glucocorticoid receptor regulatory network	21.0	2494.0	114.0	-0.655	0.322	1000.0	-1000.0	-0.072	-1000.0
TCR signaling in naïve CD8+ T cells	21.0	1958.0	93.0	-0.16	0.083	1000.0	-1000.0	-0.08	-1000.0
IL12-mediated signaling events	20.0	1814.0	87.0	-0.316	0.096	1000.0	-1000.0	-0.139	-1000.0
FOXA2 and FOXA3 transcription factor networks	20.0	939.0	46.0	-0.411	0.02	1000.0	-1000.0	-0.097	-1000.0
Glypican 2 network	19.0	76.0	4.0	-0.054	-0.039	1000.0	-1000.0	-0.019	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2334.0	120.0	-0.296	0.207	1000.0	-1000.0	-0.07	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	18.0	644.0	34.0	-0.093	0.013	1000.0	-1000.0	-0.059	-1000.0
Endothelins	18.0	1780.0	96.0	-0.205	0.018	1000.0	-1000.0	-0.083	-1000.0
Syndecan-2-mediated signaling events	17.0	1235.0	69.0	-0.143	0.018	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	17.0	1429.0	82.0	-0.171	0.015	1000.0	-1000.0	-0.083	-1000.0
Wnt signaling	17.0	124.0	7.0	-0.093	0.01	1000.0	-1000.0	-0.029	-1000.0
BCR signaling pathway	17.0	1766.0	99.0	-0.189	0.027	1000.0	-1000.0	-0.087	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	16.0	1124.0	68.0	-0.31	0.072	1000.0	-1000.0	-0.131	-1000.0
Syndecan-4-mediated signaling events	16.0	1119.0	67.0	-0.17	0.02	1000.0	-1000.0	-0.096	-1000.0
Ephrin A  reverse signaling	15.0	108.0	7.0	-0.025	-0.0	1000.0	-1000.0	-0.019	-1000.0
Nectin adhesion pathway	15.0	955.0	63.0	-0.106	0.023	1000.0	-1000.0	-0.072	-1000.0
Effects of Botulinum toxin	15.0	399.0	26.0	-0.164	0.013	1000.0	-1000.0	-0.06	-1000.0
IL27-mediated signaling events	15.0	766.0	51.0	-0.151	0.086	1000.0	-1000.0	-0.075	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.031	-1000.0	1000.0	-1000.0	-0.009	-1000.0
Thromboxane A2 receptor signaling	14.0	1500.0	105.0	-0.107	0.029	1000.0	-1000.0	-0.064	-1000.0
Integrins in angiogenesis	14.0	1209.0	84.0	-0.187	0.019	1000.0	-1000.0	-0.1	-1000.0
IGF1 pathway	14.0	825.0	57.0	-0.121	0.026	1000.0	-1000.0	-0.085	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1229.0	86.0	-0.117	0.071	1000.0	-1000.0	-0.081	-1000.0
ErbB4 signaling events	13.0	923.0	69.0	-0.183	0.064	1000.0	-1000.0	-0.09	-1000.0
Signaling events regulated by Ret tyrosine kinase	13.0	1128.0	82.0	-0.135	0.013	1000.0	-1000.0	-0.085	-1000.0
Ephrin B reverse signaling	13.0	642.0	48.0	-0.102	0.057	1000.0	-1000.0	-0.063	-1000.0
EPHB forward signaling	13.0	1120.0	85.0	-0.111	0.085	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	13.0	991.0	75.0	-0.152	0.044	1000.0	-1000.0	-0.086	-1000.0
Osteopontin-mediated events	12.0	457.0	38.0	-0.114	0.013	1000.0	-1000.0	-0.106	-1000.0
Noncanonical Wnt signaling pathway	12.0	315.0	26.0	-0.093	0.013	1000.0	-1000.0	-0.052	-1000.0
Arf6 signaling events	12.0	751.0	62.0	-0.102	0.018	1000.0	-1000.0	-0.054	-1000.0
LPA receptor mediated events	12.0	1270.0	102.0	-0.12	0.026	1000.0	-1000.0	-0.087	-1000.0
LPA4-mediated signaling events	11.0	132.0	12.0	-0.078	0.018	1000.0	-1000.0	-0.024	-1000.0
Caspase cascade in apoptosis	11.0	849.0	74.0	-0.094	0.033	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	11.0	854.0	76.0	-0.186	0.025	1000.0	-1000.0	-0.044	-1000.0
Fc-epsilon receptor I signaling in mast cells	11.0	1163.0	97.0	-0.139	0.031	1000.0	-1000.0	-0.087	-1000.0
PDGFR-alpha signaling pathway	11.0	486.0	44.0	-0.08	0.022	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	11.0	624.0	56.0	-0.124	0.019	1000.0	-1000.0	-0.081	-1000.0
IL1-mediated signaling events	11.0	690.0	62.0	-0.18	0.059	1000.0	-1000.0	-0.103	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	364.0	31.0	-0.225	0.013	1000.0	-1000.0	-0.095	-1000.0
TCGA08_retinoblastoma	11.0	92.0	8.0	-0.01	0.017	1000.0	-1000.0	-0.018	-1000.0
S1P5 pathway	10.0	178.0	17.0	-0.101	0.079	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	10.0	569.0	52.0	-0.095	0.016	1000.0	-1000.0	-0.046	-1000.0
EGFR-dependent Endothelin signaling events	10.0	221.0	21.0	-0.092	0.019	1000.0	-1000.0	-0.066	-1000.0
Visual signal transduction: Rods	10.0	568.0	52.0	-0.182	0.013	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PTP1B	9.0	750.0	76.0	-0.184	0.02	1000.0	-1000.0	-0.088	-1000.0
Syndecan-3-mediated signaling events	9.0	319.0	35.0	-0.184	0.034	1000.0	-1000.0	-0.048	-1000.0
Regulation of Androgen receptor activity	9.0	634.0	70.0	-0.283	0.027	1000.0	-1000.0	-0.065	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	226.0	28.0	-0.101	0.032	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Cones	8.0	339.0	38.0	-0.064	0.013	1000.0	-1000.0	-0.054	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	143.0	17.0	-0.039	0.013	1000.0	-1000.0	-0.043	-1000.0
Cellular roles of Anthrax toxin	8.0	338.0	39.0	-0.078	0.014	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	520.0	65.0	-0.353	0.037	1000.0	-1000.0	-0.068	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	494.0	61.0	-0.159	0.029	1000.0	-1000.0	-0.074	-1000.0
Canonical Wnt signaling pathway	8.0	454.0	51.0	-0.158	0.065	1000.0	-1000.0	-0.058	-1000.0
Angiopoietin receptor Tie2-mediated signaling	8.0	788.0	88.0	-0.149	0.032	1000.0	-1000.0	-0.125	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	685.0	78.0	-0.067	0.038	1000.0	-1000.0	-0.074	-1000.0
BARD1 signaling events	7.0	408.0	57.0	-0.055	0.037	1000.0	-1000.0	-0.062	-1000.0
TRAIL signaling pathway	7.0	363.0	48.0	-0.044	0.021	1000.0	-1000.0	-0.067	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	108.0	15.0	-0.018	0.024	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	7.0	463.0	58.0	-0.066	0.023	1000.0	-1000.0	-0.089	-1000.0
S1P4 pathway	7.0	198.0	25.0	-0.101	0.019	1000.0	-1000.0	-0.039	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	125.0	17.0	-0.029	0.022	1000.0	-1000.0	-0.045	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	880.0	136.0	-0.162	0.054	1000.0	-1000.0	-0.079	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	30.0	5.0	-0.009	0.003	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	529.0	85.0	-0.054	0.016	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	6.0	413.0	68.0	-0.129	0.023	1000.0	-1000.0	-0.101	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	332.0	52.0	-0.087	0.033	1000.0	-1000.0	-0.038	-1000.0
S1P1 pathway	6.0	235.0	36.0	-0.104	0.013	1000.0	-1000.0	-0.061	-1000.0
FAS signaling pathway (CD95)	6.0	294.0	47.0	-0.098	0.015	1000.0	-1000.0	-0.045	-1000.0
IL2 signaling events mediated by STAT5	6.0	136.0	22.0	-0.039	0.025	1000.0	-1000.0	-0.049	-1000.0
Regulation of Telomerase	6.0	636.0	102.0	-0.132	0.038	1000.0	-1000.0	-0.115	-1000.0
S1P3 pathway	6.0	290.0	42.0	-0.063	0.02	1000.0	-1000.0	-0.043	-1000.0
ErbB2/ErbB3 signaling events	5.0	386.0	65.0	-0.116	0.022	1000.0	-1000.0	-0.056	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	283.0	54.0	-0.078	0.025	1000.0	-1000.0	-0.101	-1000.0
Ceramide signaling pathway	5.0	381.0	76.0	-0.117	0.036	1000.0	-1000.0	-0.047	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	213.0	37.0	-0.052	0.02	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by HDAC Class III	5.0	214.0	40.0	-0.165	0.02	1000.0	-1000.0	-0.045	-1000.0
Retinoic acid receptors-mediated signaling	5.0	345.0	58.0	-0.075	0.026	1000.0	-1000.0	-0.069	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	238.0	45.0	-0.078	0.038	1000.0	-1000.0	-0.092	-1000.0
Rapid glucocorticoid signaling	5.0	100.0	20.0	-0.045	0.016	1000.0	-1000.0	-0.026	-1000.0
TCGA08_rtk_signaling	4.0	104.0	26.0	-0.035	0.038	1000.0	-1000.0	-0.019	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	344.0	74.0	-0.187	0.062	1000.0	-1000.0	-0.081	-1000.0
Class I PI3K signaling events	4.0	346.0	73.0	-0.077	0.029	1000.0	-1000.0	-0.069	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	155.0	33.0	-0.111	0.03	1000.0	-1000.0	-0.045	-1000.0
PDGFR-beta signaling pathway	4.0	421.0	97.0	-0.058	0.035	1000.0	-1000.0	-0.077	-1000.0
p38 MAPK signaling pathway	4.0	208.0	44.0	-0.119	0.025	1000.0	-1000.0	-0.061	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.002	0.013	1000.0	-1000.0	-0.017	-1000.0
Aurora A signaling	3.0	195.0	60.0	-0.133	0.038	1000.0	-1000.0	-0.047	-1000.0
EPO signaling pathway	3.0	169.0	55.0	-0.028	0.045	1000.0	-1000.0	-0.087	-1000.0
mTOR signaling pathway	3.0	196.0	53.0	-0.019	0.022	1000.0	-1000.0	-0.06	-1000.0
TCGA08_p53	3.0	23.0	7.0	-0.008	0.013	1000.0	-1000.0	-0.013	-1000.0
Regulation of p38-alpha and p38-beta	3.0	206.0	54.0	-0.077	0.033	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	421.0	125.0	-0.084	0.05	1000.0	-1000.0	-0.094	-1000.0
Insulin Pathway	3.0	272.0	74.0	-0.149	0.027	1000.0	-1000.0	-0.089	-1000.0
VEGFR1 specific signals	3.0	184.0	56.0	-0.031	0.03	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PRL	3.0	129.0	34.0	-0.111	0.032	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	3.0	190.0	51.0	-0.093	0.139	1000.0	-1000.0	-0.189	-1000.0
Canonical NF-kappaB pathway	2.0	85.0	39.0	-0.041	0.065	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class II	2.0	187.0	75.0	-0.084	0.035	1000.0	-1000.0	-0.041	-1000.0
Arf6 downstream pathway	2.0	95.0	43.0	-0.029	0.024	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	2.0	113.0	49.0	-0.041	0.031	1000.0	-1000.0	-0.047	-1000.0
HIF-2-alpha transcription factor network	2.0	125.0	43.0	-0.092	0.093	1000.0	-1000.0	-0.092	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	227.0	83.0	-0.069	0.054	1000.0	-1000.0	-0.068	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	105.0	36.0	-0.052	0.027	1000.0	-1000.0	-0.065	-1000.0
E-cadherin signaling in keratinocytes	2.0	89.0	43.0	-0.033	0.036	1000.0	-1000.0	-0.064	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	41.0	23.0	-0.027	0.038	1000.0	-1000.0	-0.049	-1000.0
Circadian rhythm pathway	1.0	37.0	22.0	-0.021	0.041	1000.0	-1000.0	-0.05	-1000.0
Aurora C signaling	1.0	10.0	7.0	-0.002	0.016	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	1.0	47.0	32.0	-0.042	0.036	1000.0	-1000.0	-0.066	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	87.0	68.0	-0.042	0.043	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class I	1.0	165.0	104.0	-0.041	0.047	1000.0	-1000.0	-0.066	-1000.0
FoxO family signaling	1.0	103.0	64.0	-0.079	0.128	1000.0	-1000.0	-0.073	-1000.0
Atypical NF-kappaB pathway	1.0	61.0	31.0	-0.01	0.039	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	124.0	76.0	-0.032	0.056	1000.0	-1000.0	-0.081	-1000.0
Arf6 trafficking events	1.0	107.0	71.0	-0.031	0.041	1000.0	-1000.0	-0.07	-1000.0
Aurora B signaling	1.0	116.0	67.0	-0.065	0.034	1000.0	-1000.0	-0.069	-1000.0
PLK1 signaling events	0.0	74.0	85.0	-0.011	0.032	1000.0	-1000.0	-0.045	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.001	0.031	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	0.01	0.024	1000.0	-1000.0	-0.023	-1000.0
Arf1 pathway	0.0	37.0	54.0	-0.011	0.026	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.036	1000.0	-1000.0	-0.036	-1000.0
Total	1219	76886	7203	-16.3025751593	-994.618194352	131000	-131000	-8.61663485609	-131000