Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	107 (69%)	47	0.13595	1	0.0064799	1	0.04024	1	0.16079	1	0.21875	1	0.88866	1	0.01202	1	1	1	0.86818	1
TP53	73 (47%)	81	0.00457	0.964	0.00334	0.721	9.9999e-06	0.0023	0.20047	1	0.73613	1	9.9999e-06	0.0023	0.00118	0.258	0.62055	1	0.49359	1
KRAS	59 (38%)	95	0.03311	1	0.0080199	1	0.079349	1	0.71766	1	0.99214	1	0.30182	1	0.72208	1	0.63137	1	0.52628	1
NRAS	15 (10%)	139	0.077099	1	0.092069	1	0.78328	1	0.46757	1	0.95541	1	0.14988	1	0.73429	1	1	1	1	1
SMAD4	18 (12%)	136	0.30306	1	0.22727	1	0.02114	1	0.85248	1	0.56935	1	0.60318	1	0.51507	1	1	1	0.8655	1
FBXW7	29 (19%)	125	0.22765	1	0.055899	1	0.00261	0.566	0.00342	0.735	0.19448	1	0.15203	1	0.00434	0.92	1	1	0.1816	1
SMAD2	10 (6%)	144	0.098979	1	0.10859	1	0.02782	1	1	1	0.94125	1	0.19299	1	0.80509	1	1	1	1	1
BRAF	20 (13%)	134	9.9999e-06	0.0023	9.9999e-06	0.0023	4e-05	0.00892	0.72211	1	0.52459	1	0.01139	1	9.9999e-06	0.0023	0.46154	1	0.03936	1
FAM123B	19 (12%)	135	0.20804	1	0.1844	1	0.0264	1	0.2848	1	0.18896	1	0.17889	1	0.34994	1	0.42457	1	0.41644	1
MGC42105	10 (6%)	144	0.00432	0.92	0.13955	1	0.25185	1	0.41052	1	0.17362	1	0.47594	1	0.19395	1	1	1	0.59442	1
ACVR1B	13 (8%)	141	0.36582	1	0.15784	1	0.01675	1	0.70117	1	0.43151	1	0.14652	1	0.10253	1	1	1	0.37341	1
DNMT1	12 (8%)	142	0.02916	1	0.0078299	1	0.087909	1	0.051249	1	0.34796	1	0.03883	1	0.01055	1	1	1	0.00423	0.905
PCBP1	4 (3%)	150	0.32939	1	0.43415	1	0.29664	1	NA	NA	NA	NA	0.81848	1	0.6365	1	1	1	0.60185	1
CDC27	10 (6%)	144	0.0025	0.545	0.073359	1	0.0071099	1	1	1	0.9545	1	0.4362	1	0.01971	1	0.18612	1	0.01392	1
PIK3CA	26 (17%)	128	0.33098	1	0.58167	1	0.01494	1	0.11995	1	0.85733	1	0.03895	1	0.56214	1	0.51361	1	0.2293	1
BCOR	6 (4%)	148	0.03459	1	0.054459	1	0.24366	1	0.19963	1	0.60149	1	0.63096	1	0.11951	1	1	1	0.096459	1
ZHX2	8 (5%)	146	0.21722	1	0.22762	1	0.17089	1	0.23028	1	0.5774	1	0.91857	1	0.084799	1	1	1	0.19635	1
KLHL5	5 (3%)	149	0.37266	1	0.29712	1	0.42077	1	0.22151	1	0.87459	1	0.63207	1	1	1	1	1	0.1598	1
CASP8	10 (6%)	144	0.00049	0.109	3e-05	0.00672	0.00109	0.24	0.01578	1	0.14957	1	0.03577	1	2e-05	0.0045	1	1	0.076119	1
PCDHGB1	7 (5%)	147	0.1088	1	0.26721	1	0.14356	1	0.43045	1	1	1	0.61754	1	0.52011	1	1	1	0.19594	1
UBXN11	3 (2%)	151	NA	NA	NA	NA	0.32562	1	NA	NA	NA	NA	0.20115	1	0.055799	1	1	1	0.60359	1
MIER3	10 (6%)	144	0.00106	0.234	0.00487	1	0.00496	1	0.77218	1	0.78169	1	0.94489	1	0.01162	1	1	1	0.17489	1
TBC1D10C	3 (2%)	151	0.23736	1	0.13009	1	0.78346	1	NA	NA	NA	NA	0.13312	1	0.23953	1	1	1	0.60258	1
TCF7L2	11 (7%)	143	0.21829	1	1	1	0.15135	1	0.94891	1	0.86047	1	0.67183	1	1	1	1	1	0.31906	1
PCDHGA9	5 (3%)	149	0.37209	1	0.42157	1	0.42532	1	0.6504	1	0.38458	1	0.11458	1	0.25898	1	1	1	1	1
PCDHGA7	5 (3%)	149	0.70029	1	0.84785	1	0.04495	1	NA	NA	NA	NA	1	1	0.66503	1	1	1	0.35951	1
KLK2	3 (2%)	151	0.41747	1	0.1307	1	0.7842	1	NA	NA	NA	NA	0.72069	1	0.23953	1	1	1	NA	NA