Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.02 0.139 -9999.0 0.0 -0.614 17.0 17.0 IHH 0.005 0.088 -9999.0 0.0 -0.498 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.092 0.2 -9999.0 0.0 -0.484 78.0 78.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.091 0.199 0.48 78.0 -9999.0 0.0 78.0 SMO/beta Arrestin2 0.016 0.096 -9999.0 0.0 -0.543 5.0 5.0 SMO 0.01 0.101 -9999.0 0.0 -0.546 6.0 6.0 AKT1 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.065 -9999.0 0.0 -0.441 9.0 9.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.011 0.099 -9999.0 0.0 -0.537 6.0 6.0 STIL -0.038 0.166 -9999.0 0.0 -0.53 6.0 6.0 DHH N/PTCH2 0.003 0.07 -9999.0 0.0 -0.318 19.0 19.0 DHH N/PTCH1 0.014 0.1 -9999.0 0.0 -0.525 6.0 6.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.007 0.091 -9999.0 0.0 -0.441 18.0 18.0 PTHLH 0.018 0.157 -9999.0 0.0 -0.892 8.0 8.0 determination of left/right symmetry 0.011 0.099 -9999.0 0.0 -0.537 6.0 6.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.018 0.155 -9999.0 0.0 -0.878 8.0 8.0 IHH N/Hhip -0.063 0.159 -9999.0 0.0 -0.352 95.0 95.0 DHH N/Hhip -0.064 0.152 -9999.0 0.0 -0.442 18.0 18.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.011 0.099 -9999.0 0.0 -0.537 6.0 6.0 pancreas development -0.086 0.186 -9999.0 0.0 -0.441 93.0 93.0 HHAT 0.008 0.043 -9999.0 0.0 -0.441 4.0 4.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.05 0.163 -9999.0 0.0 -0.462 57.0 57.0 somite specification 0.011 0.099 -9999.0 0.0 -0.537 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.045 0.174 -9999.0 0.0 -0.397 76.0 76.0 SHH Np/Cholesterol/PTCH2 -0.06 0.174 -9999.0 0.0 -0.439 74.0 74.0 SHH Np/Cholesterol/Megalin -0.1 0.213 -9999.0 0.0 -0.469 102.0 102.0 SHH -0.081 0.217 -9999.0 0.0 -0.544 77.0 77.0 catabolic process 0.022 0.092 -9999.0 0.0 -0.552 5.0 5.0 SMO/Vitamin D3 -0.034 0.168 -9999.0 0.0 -0.529 8.0 8.0 SHH Np/Cholesterol/Hhip -0.111 0.19 -9999.0 0.0 -0.462 76.0 76.0 LRP2 -0.056 0.205 -9999.0 0.0 -0.736 36.0 36.0 receptor-mediated endocytosis -0.049 0.176 -9999.0 0.0 -0.565 15.0 15.0 SHH Np/Cholesterol/BOC -0.064 0.177 -9999.0 0.0 -0.445 73.0 73.0 SHH Np/Cholesterol/CDO -0.059 0.173 -9999.0 0.0 -0.439 73.0 73.0 mesenchymal cell differentiation 0.11 0.188 0.459 76.0 -9999.0 0.0 76.0 mol:Vitamin D3 -0.042 0.175 -9999.0 0.0 -0.395 76.0 76.0 IHH N/PTCH2 0.013 0.061 -9999.0 0.0 -0.376 6.0 6.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.023 0.093 -9999.0 0.0 -0.557 5.0 5.0 Megalin/LRPAP1 -0.034 0.158 -9999.0 0.0 -0.556 36.0 36.0 PTCH2 0.01 0.036 -9999.0 0.0 -0.736 1.0 1.0 SHH Np/Cholesterol -0.066 0.173 -9999.0 0.0 -0.445 73.0 73.0 PTCH1 0.022 0.093 -9999.0 0.0 -0.554 5.0 5.0 HHIP -0.086 0.186 -9999.0 0.0 -0.441 93.0 93.0