E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.021 0.034 -9999.0 0.0 -0.307 3.0 3.0 KLHL20 0.042 0.074 0.206 26.0 -0.224 7.0 33.0 CYFIP2 0.025 0.021 -9999.0 0.0 -0.399 1.0 1.0 Rac1/GDP 0.068 0.08 0.27 7.0 -9999.0 0.0 7.0 ENAH 0.02 0.034 -9999.0 0.0 -0.307 3.0 3.0 AP1M1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.008 0.027 -9999.0 0.0 -0.158 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.053 -9999.0 0.0 -0.202 14.0 14.0 RAPGEF1 0.055 0.081 0.299 5.0 -9999.0 0.0 5.0 CTNND1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.029 0.036 -9999.0 0.0 -0.314 3.0 3.0 CRK 0.055 0.076 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.051 0.018 -9999.0 0.0 -0.239 1.0 1.0 alphaE/beta7 Integrin 0.023 0.058 -9999.0 0.0 -0.268 15.0 15.0 IQGAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.02 0.035 -9999.0 0.0 -0.307 3.0 3.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.017 0.087 -9999.0 0.0 -0.234 42.0 42.0 PI3K 0.008 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.017 -9999.0 0.0 -0.282 1.0 1.0 TIAM1 -0.015 0.124 -9999.0 0.0 -0.399 40.0 40.0 E-cadherin(dimer)/Ca2+ 0.061 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.045 0.102 24.0 -9999.0 0.0 24.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.08 0.081 0.271 6.0 -9999.0 0.0 6.0 actin cytoskeleton organization 0.039 0.06 0.171 29.0 -0.167 6.0 35.0 CDC42/GDP 0.075 0.08 0.238 11.0 -9999.0 0.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.019 0.012 -9999.0 0.0 -0.206 1.0 1.0 ITGB7 0.011 0.079 -9999.0 0.0 -0.399 15.0 15.0 RAC1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.066 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.072 0.088 0.285 7.0 -0.29 1.0 8.0 CDC42/GTP/IQGAP1 0.032 0.017 -9999.0 0.0 -0.236 1.0 1.0 JUP 0.025 0.021 -9999.0 0.0 -0.399 1.0 1.0 p120 catenin/RhoA/GDP 0.088 0.08 0.281 5.0 -9999.0 0.0 5.0 RAC1/GTP/IQGAP1 0.031 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.016 -9999.0 0.0 -0.282 1.0 1.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.022 -9999.0 0.0 -0.399 1.0 1.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.032 0.047 0.134 30.0 -0.152 4.0 34.0 NME1 0.017 0.067 0.369 1.0 -0.423 9.0 10.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.019 0.034 -9999.0 0.0 -0.307 3.0 3.0 regulation of cell-cell adhesion 0.012 0.015 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.079 0.071 0.287 4.0 -9999.0 0.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.055 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.036 0.054 0.15 29.0 -0.186 4.0 33.0 VAV2 0.072 0.133 -9999.0 0.0 -0.598 10.0 10.0 RAP1/GDP 0.087 0.078 0.28 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.019 0.033 -9999.0 0.0 -0.299 3.0 3.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.021 -9999.0 0.0 -0.399 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.043 0.049 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.013 0.011 -9999.0 0.0 -0.155 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.013 0.029 -9999.0 0.0 -0.309 2.0 2.0 PIK3CA 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.063 -9999.0 0.0 -0.342 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.052 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.036 -9999.0 0.0 -0.319 3.0 3.0