Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.056 0.3 11.0 -0.241 1.0 12.0 KIRREL 0.022 0.044 -9999.0 0.0 -0.407 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.029 0.056 0.242 1.0 -0.3 11.0 12.0 PLCG1 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.042 0.074 0.233 1.0 -0.235 26.0 27.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.02 0.029 0.161 1.0 -0.209 4.0 5.0 FYN 0.013 0.062 0.271 12.0 -0.203 13.0 25.0 mol:Ca2+ 0.027 0.052 -9999.0 0.0 -0.233 10.0 10.0 mol:DAG 0.028 0.052 -9999.0 0.0 -0.234 10.0 10.0 NPHS2 -0.005 0.047 -9999.0 0.0 -0.419 4.0 4.0 mol:IP3 0.028 0.052 -9999.0 0.0 -0.234 10.0 10.0 regulation of endocytosis 0.036 0.047 0.213 1.0 -0.241 3.0 4.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.051 0.215 1.0 -0.228 13.0 14.0 establishment of cell polarity 0.028 0.056 0.241 1.0 -0.3 11.0 12.0 Nephrin/NEPH1/podocin/NCK1-2 0.063 0.055 0.237 1.0 -0.377 1.0 2.0 Nephrin/NEPH1/beta Arrestin2 0.037 0.048 0.221 1.0 -0.243 3.0 4.0 NPHS1 0.014 0.062 0.337 1.0 -0.426 7.0 8.0 Nephrin/NEPH1/podocin 0.038 0.046 0.218 1.0 -0.204 13.0 14.0 TJP1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.053 -9999.0 0.0 -0.235 10.0 10.0 CD2AP 0.013 0.073 -9999.0 0.0 -0.399 13.0 13.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.055 0.233 1.0 -0.231 13.0 14.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.01 0.078 0.28 10.0 -0.243 19.0 29.0 cytoskeleton organization 0.01 0.041 0.195 6.0 -0.244 4.0 10.0 Nephrin/NEPH1 0.025 0.04 0.198 1.0 -0.205 11.0 12.0 Nephrin/NEPH1/ZO-1 0.04 0.049 0.228 1.0 -0.232 11.0 12.0