Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.013 0.098 -9999.0 0.0 -0.401 18.0 18.0 IHH 0.018 0.085 -9999.0 0.0 -0.454 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.044 0.124 0.188 1.0 -0.25 105.0 106.0 LRPAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.123 0.248 105.0 -0.186 1.0 106.0 SMO/beta Arrestin2 0.018 0.09 -9999.0 0.0 -0.461 6.0 6.0 SMO 0.006 0.085 -9999.0 0.0 -0.379 14.0 14.0 AKT1 0.001 0.105 -9999.0 0.0 -0.343 27.0 27.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.061 -9999.0 0.0 -0.399 9.0 9.0 ADRBK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.007 0.085 -9999.0 0.0 -0.374 14.0 14.0 STIL -0.015 0.106 -9999.0 0.0 -0.359 8.0 8.0 DHH N/PTCH2 0.023 0.067 -9999.0 0.0 -0.282 19.0 19.0 DHH N/PTCH1 0.02 0.091 -9999.0 0.0 -0.411 8.0 8.0 PIK3CA 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.005 0.086 -9999.0 0.0 -0.399 18.0 18.0 PTHLH 0.008 0.124 -9999.0 0.0 -0.741 8.0 8.0 determination of left/right symmetry 0.007 0.085 -9999.0 0.0 -0.374 14.0 14.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.008 0.123 -9999.0 0.0 -0.733 8.0 8.0 IHH N/Hhip -0.041 0.153 -9999.0 0.0 -0.32 95.0 95.0 DHH N/Hhip -0.041 0.147 -9999.0 0.0 -0.304 97.0 97.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.007 0.085 -9999.0 0.0 -0.374 14.0 14.0 pancreas development -0.064 0.172 -9999.0 0.0 -0.398 88.0 88.0 HHAT 0.022 0.041 -9999.0 0.0 -0.399 4.0 4.0 PI3K 0.038 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.029 0.144 -9999.0 0.0 -0.401 55.0 55.0 somite specification 0.007 0.085 -9999.0 0.0 -0.374 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.016 0.104 0.195 4.0 -0.336 11.0 15.0 SHH Np/Cholesterol/PTCH2 -0.017 0.097 0.188 4.0 -0.228 72.0 76.0 SHH Np/Cholesterol/Megalin -0.038 0.118 0.181 4.0 -0.245 98.0 102.0 SHH -0.038 0.12 0.276 4.0 -0.3 70.0 74.0 catabolic process 0.018 0.078 -9999.0 0.0 -0.32 16.0 16.0 SMO/Vitamin D3 -0.013 0.106 -9999.0 0.0 -0.41 8.0 8.0 SHH Np/Cholesterol/Hhip -0.061 0.126 0.185 3.0 -0.234 141.0 144.0 LRP2 -0.032 0.121 -9999.0 0.0 -0.423 36.0 36.0 receptor-mediated endocytosis -0.026 0.107 -9999.0 0.0 -0.424 10.0 10.0 SHH Np/Cholesterol/BOC -0.02 0.1 0.188 3.0 -0.23 76.0 79.0 SHH Np/Cholesterol/CDO -0.017 0.096 0.188 3.0 -0.228 71.0 74.0 mesenchymal cell differentiation 0.061 0.126 0.233 141.0 -0.183 3.0 144.0 mol:Vitamin D3 -0.009 0.113 0.201 21.0 -0.337 11.0 32.0 IHH N/PTCH2 0.03 0.057 -9999.0 0.0 -0.274 13.0 13.0 CDON 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.026 0.08 -9999.0 0.0 -0.323 16.0 16.0 Megalin/LRPAP1 0.006 0.094 -9999.0 0.0 -0.301 36.0 36.0 PTCH2 0.024 0.023 -9999.0 0.0 -0.423 1.0 1.0 SHH Np/Cholesterol -0.026 0.09 -9999.0 0.0 -0.226 71.0 71.0 PTCH1 0.018 0.078 -9999.0 0.0 -0.321 16.0 16.0 HHIP -0.064 0.172 -9999.0 0.0 -0.399 88.0 88.0