Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.026 0.092 -9999.0 0.0 -0.717 1.0 1.0 IHH 0.032 0.062 -9999.0 0.0 -0.628 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.057 0.15 -9999.0 0.0 -0.322 30.0 30.0 LRPAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.057 0.149 0.32 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.041 0.079 -9999.0 0.0 -0.537 1.0 1.0 SMO 0.026 0.071 -9999.0 0.0 -0.562 1.0 1.0 AKT1 0.011 0.112 -9999.0 0.0 -0.384 3.0 3.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.026 0.07 -9999.0 0.0 -0.553 1.0 1.0 STIL -0.011 0.119 -9999.0 0.0 -0.362 7.0 7.0 DHH N/PTCH2 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.043 0.069 -9999.0 0.0 -0.496 1.0 1.0 PIK3CA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.025 0.098 -9999.0 0.0 -0.877 1.0 1.0 determination of left/right symmetry 0.026 0.07 -9999.0 0.0 -0.553 1.0 1.0 PIK3R1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.025 0.097 -9999.0 0.0 -0.867 1.0 1.0 IHH N/Hhip -0.047 0.191 -9999.0 0.0 -0.417 30.0 30.0 DHH N/Hhip -0.04 0.169 -9999.0 0.0 -0.372 30.0 30.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.026 0.07 -9999.0 0.0 -0.553 1.0 1.0 pancreas development -0.08 0.22 -9999.0 0.0 -0.511 30.0 30.0 HHAT -0.017 0.155 -9999.0 0.0 -0.512 13.0 13.0 PI3K 0.047 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.076 0.207 -9999.0 0.0 -0.458 32.0 32.0 somite specification 0.026 0.07 -9999.0 0.0 -0.553 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.007 0.099 -9999.0 0.0 -0.376 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.001 0.092 -9999.0 0.0 -0.285 13.0 13.0 SHH Np/Cholesterol/Megalin 0.002 0.092 -9999.0 0.0 -0.286 13.0 13.0 SHH -0.017 0.114 0.229 1.0 -0.361 14.0 15.0 catabolic process 0.029 0.071 -9999.0 0.0 -0.548 1.0 1.0 SMO/Vitamin D3 0.01 0.101 -9999.0 0.0 -0.416 2.0 2.0 SHH Np/Cholesterol/Hhip -0.059 0.156 -9999.0 0.0 -0.318 36.0 36.0 LRP2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.007 0.099 -9999.0 0.0 -0.459 1.0 1.0 SHH Np/Cholesterol/BOC 0.003 0.09 -9999.0 0.0 -0.286 12.0 12.0 SHH Np/Cholesterol/CDO 0.001 0.092 -9999.0 0.0 -0.286 13.0 13.0 mesenchymal cell differentiation 0.059 0.155 0.316 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 0.015 0.107 -9999.0 0.0 -0.377 3.0 3.0 IHH N/PTCH2 0.047 0.039 -9999.0 0.0 -0.392 1.0 1.0 CDON 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.037 0.074 -9999.0 0.0 -0.555 1.0 1.0 Megalin/LRPAP1 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.088 -9999.0 0.0 -0.286 13.0 13.0 PTCH1 0.029 0.072 -9999.0 0.0 -0.55 1.0 1.0 HHIP -0.08 0.22 -9999.0 0.0 -0.512 30.0 30.0