E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.14 -9999.0 0.0 -0.498 15.0 15.0 KLHL20 0.03 0.118 0.222 14.0 -0.246 18.0 32.0 CYFIP2 0.012 0.107 -9999.0 0.0 -0.442 11.0 11.0 Rac1/GDP 0.046 0.138 0.294 5.0 -0.405 7.0 12.0 ENAH -0.016 0.147 -9999.0 0.0 -0.511 15.0 15.0 AP1M1 0.034 0.035 -9999.0 0.0 -0.467 1.0 1.0 RAP1B 0.034 0.035 -9999.0 0.0 -0.467 1.0 1.0 RAP1A 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.081 -9999.0 0.0 -0.274 13.0 13.0 CDC42/GTP 0.037 0.1 -9999.0 0.0 -0.354 6.0 6.0 ABI1/Sra1/Nap1 -0.028 0.058 -9999.0 0.0 -0.176 23.0 23.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.02 0.121 -9999.0 0.0 -0.263 28.0 28.0 RAPGEF1 0.034 0.154 0.336 3.0 -0.485 11.0 14.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.146 -9999.0 0.0 -0.509 15.0 15.0 CRK 0.029 0.159 -9999.0 0.0 -0.527 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.078 -9999.0 0.0 -0.287 10.0 10.0 alphaE/beta7 Integrin 0.017 0.096 -9999.0 0.0 -0.331 14.0 14.0 IQGAP1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.064 -9999.0 0.0 -0.244 10.0 10.0 Rap1/GTP/I-afadin 0.055 0.058 -9999.0 0.0 -0.259 6.0 6.0 DLG1 -0.008 0.141 -9999.0 0.0 -0.498 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.054 -9999.0 0.0 -0.261 6.0 6.0 MLLT4 0.024 0.076 -9999.0 0.0 -0.467 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.049 0.058 -9999.0 0.0 -0.27 5.0 5.0 PI3K -0.011 0.072 -9999.0 0.0 -0.348 6.0 6.0 ARF6 0.029 0.049 -9999.0 0.0 -0.467 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.083 -9999.0 0.0 -0.336 10.0 10.0 TIAM1 0.029 0.051 -9999.0 0.0 -0.374 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.053 0.09 -9999.0 0.0 -0.251 14.0 14.0 AKT1 0.027 0.067 0.193 3.0 -0.202 5.0 8.0 PIK3R1 0.029 0.059 -9999.0 0.0 -0.467 3.0 3.0 CDH1 0.013 0.106 -9999.0 0.0 -0.467 10.0 10.0 RhoA/GDP 0.062 0.145 0.329 6.0 -0.405 7.0 13.0 actin cytoskeleton organization 0.031 0.097 0.205 17.0 -0.178 18.0 35.0 CDC42/GDP 0.057 0.145 0.326 7.0 -0.405 7.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.055 -9999.0 0.0 -0.228 10.0 10.0 ITGB7 0.003 0.124 -9999.0 0.0 -0.467 14.0 14.0 RAC1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.096 -9999.0 0.0 -0.268 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.082 -9999.0 0.0 -0.249 14.0 14.0 mol:GDP 0.048 0.158 0.33 7.0 -0.416 11.0 18.0 CDC42/GTP/IQGAP1 0.043 0.019 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.034 0.017 -9999.0 0.0 -0.189 1.0 1.0 p120 catenin/RhoA/GDP 0.07 0.15 0.335 6.0 -0.415 7.0 13.0 RAC1/GTP/IQGAP1 0.041 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.051 0.028 -9999.0 0.0 -0.336 1.0 1.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.018 -9999.0 0.0 -0.189 1.0 1.0 CTNNA1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.029 0.076 0.168 20.0 -0.167 5.0 25.0 NME1 0.032 0.035 -9999.0 0.0 -0.467 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.14 -9999.0 0.0 -0.498 15.0 15.0 regulation of cell-cell adhesion -0.002 0.067 -9999.0 0.0 -0.307 6.0 6.0 WASF2 0.011 0.053 0.11 13.0 -0.135 4.0 17.0 Rap1/GTP 0.068 0.124 0.322 2.0 -0.402 6.0 8.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.114 -9999.0 0.0 -0.246 24.0 24.0 CCND1 0.032 0.09 0.191 20.0 -0.207 5.0 25.0 VAV2 0.004 0.286 0.415 1.0 -0.718 23.0 24.0 RAP1/GDP 0.072 0.137 0.344 4.0 -0.415 6.0 10.0 adherens junction assembly -0.01 0.136 -9999.0 0.0 -0.48 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.016 0.111 -9999.0 0.0 -0.243 24.0 24.0 E-cadherin/beta catenin -0.002 0.078 -9999.0 0.0 -0.33 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.019 0.137 -9999.0 0.0 -0.562 11.0 11.0 PIK3CA 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.043 0.132 -9999.0 0.0 -0.39 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.04 0.096 -9999.0 0.0 -0.293 14.0 14.0 ITGAE 0.027 0.026 -9999.0 0.0 -0.189 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.149 -9999.0 0.0 -0.522 15.0 15.0