Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.059 0.164 0.4 104.0 -9999.0 0.0 104.0 KIRREL -0.032 0.145 -9999.0 0.0 -0.581 38.0 38.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.059 0.164 -9999.0 0.0 -0.401 104.0 104.0 PLCG1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.057 0.155 -9999.0 0.0 -0.377 89.0 89.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.023 0.112 -9999.0 0.0 -0.313 62.0 62.0 FYN -0.042 0.127 -9999.0 0.0 -0.343 65.0 65.0 mol:Ca2+ -0.041 0.134 -9999.0 0.0 -0.365 61.0 61.0 mol:DAG -0.041 0.135 -9999.0 0.0 -0.367 61.0 61.0 NPHS2 -0.021 0.092 -9999.0 0.0 -0.468 23.0 23.0 mol:IP3 -0.041 0.135 -9999.0 0.0 -0.367 61.0 61.0 regulation of endocytosis -0.032 0.121 -9999.0 0.0 -0.324 61.0 61.0 Nephrin/NEPH1/podocin/Cholesterol -0.047 0.133 -9999.0 0.0 -0.316 95.0 95.0 establishment of cell polarity -0.059 0.164 -9999.0 0.0 -0.4 104.0 104.0 Nephrin/NEPH1/podocin/NCK1-2 -0.031 0.126 -9999.0 0.0 -0.334 62.0 62.0 Nephrin/NEPH1/beta Arrestin2 -0.032 0.123 -9999.0 0.0 -0.328 61.0 61.0 NPHS1 -0.057 0.171 -9999.0 0.0 -0.508 73.0 73.0 Nephrin/NEPH1/podocin -0.041 0.128 -9999.0 0.0 -0.345 65.0 65.0 TJP1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 NCK1 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 NCK2 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.04 0.136 -9999.0 0.0 -0.368 61.0 61.0 CD2AP -0.017 0.127 -9999.0 0.0 -0.577 29.0 29.0 Nephrin/NEPH1/podocin/GRB2 -0.04 0.134 -9999.0 0.0 -0.363 61.0 61.0 GRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.051 0.149 -9999.0 0.0 -0.387 74.0 74.0 cytoskeleton organization -0.027 0.132 -9999.0 0.0 -0.37 60.0 60.0 Nephrin/NEPH1 -0.04 0.119 -9999.0 0.0 -0.284 104.0 104.0 Nephrin/NEPH1/ZO-1 -0.039 0.136 -9999.0 0.0 -0.374 61.0 61.0