Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.05 0.219 -9999.0 0.0 -0.636 51.0 51.0 IHH -0.039 0.169 -9999.0 0.0 -0.625 43.0 43.0 SHH Np/Cholesterol/GAS1 -0.08 0.157 -9999.0 0.0 -0.304 185.0 185.0 LRPAP1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 dorsoventral neural tube patterning 0.08 0.156 0.302 185.0 -9999.0 0.0 185.0 SMO/beta Arrestin2 -0.036 0.192 -9999.0 0.0 -0.642 34.0 34.0 SMO -0.044 0.202 -9999.0 0.0 -0.668 36.0 36.0 AKT1 -0.005 0.111 -9999.0 0.0 -0.504 11.0 11.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.034 0.143 -9999.0 0.0 -0.481 55.0 55.0 ADRBK1 0.01 0.031 -9999.0 0.0 -0.518 2.0 2.0 heart looping -0.043 0.198 -9999.0 0.0 -0.653 36.0 36.0 STIL -0.026 0.162 -9999.0 0.0 -0.587 29.0 29.0 DHH N/PTCH2 -0.041 0.154 -9999.0 0.0 -0.426 77.0 77.0 DHH N/PTCH1 -0.047 0.17 -9999.0 0.0 -0.568 26.0 26.0 PIK3CA 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 DHH -0.03 0.145 -9999.0 0.0 -0.541 44.0 44.0 PTHLH -0.075 0.293 -9999.0 0.0 -0.924 51.0 51.0 determination of left/right symmetry -0.043 0.198 -9999.0 0.0 -0.653 36.0 36.0 PIK3R1 0.008 0.042 -9999.0 0.0 -0.581 3.0 3.0 skeletal system development -0.074 0.289 -9999.0 0.0 -0.911 51.0 51.0 IHH N/Hhip -0.084 0.204 -9999.0 0.0 -0.461 126.0 126.0 DHH N/Hhip -0.079 0.187 -9999.0 0.0 -0.417 131.0 131.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.198 -9999.0 0.0 -0.653 36.0 36.0 pancreas development -0.08 0.207 -9999.0 0.0 -0.543 98.0 98.0 HHAT 0.004 0.064 -9999.0 0.0 -0.581 7.0 7.0 PI3K 0.013 0.04 -9999.0 0.0 -0.423 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.13 0.236 -9999.0 0.0 -0.516 160.0 160.0 somite specification -0.043 0.198 -9999.0 0.0 -0.653 36.0 36.0 SHH Np/Cholesterol/PTCH1 -0.032 0.17 -9999.0 0.0 -0.604 31.0 31.0 SHH Np/Cholesterol/PTCH2 -0.023 0.115 -9999.0 0.0 -0.315 77.0 77.0 SHH Np/Cholesterol/Megalin -0.023 0.107 -9999.0 0.0 -0.291 76.0 76.0 SHH -0.009 0.106 -9999.0 0.0 -0.414 38.0 38.0 catabolic process -0.032 0.163 -9999.0 0.0 -0.569 24.0 24.0 SMO/Vitamin D3 -0.039 0.193 -9999.0 0.0 -0.633 39.0 39.0 SHH Np/Cholesterol/Hhip -0.053 0.15 -9999.0 0.0 -0.33 124.0 124.0 LRP2 -0.028 0.12 -9999.0 0.0 -0.455 43.0 43.0 receptor-mediated endocytosis -0.043 0.189 -9999.0 0.0 -0.603 41.0 41.0 SHH Np/Cholesterol/BOC -0.026 0.117 -9999.0 0.0 -0.296 87.0 87.0 SHH Np/Cholesterol/CDO -0.008 0.1 -9999.0 0.0 -0.337 47.0 47.0 mesenchymal cell differentiation 0.053 0.149 0.328 124.0 -9999.0 0.0 124.0 mol:Vitamin D3 -0.03 0.171 -9999.0 0.0 -0.607 31.0 31.0 IHH N/PTCH2 -0.043 0.159 -9999.0 0.0 -0.436 78.0 78.0 CDON -0.001 0.081 -9999.0 0.0 -0.518 14.0 14.0 IHH N/PTCH1 -0.031 0.165 -9999.0 0.0 -0.575 24.0 24.0 Megalin/LRPAP1 -0.012 0.087 -9999.0 0.0 -0.319 44.0 44.0 PTCH2 -0.028 0.142 -9999.0 0.0 -0.539 42.0 42.0 SHH Np/Cholesterol -0.008 0.082 -9999.0 0.0 -0.321 38.0 38.0 PTCH1 -0.032 0.164 -9999.0 0.0 -0.572 24.0 24.0 HHIP -0.08 0.207 -9999.0 0.0 -0.544 98.0 98.0