Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.036 -9999.0 0.0 -0.255 10.0 10.0 epithelial cell differentiation 0.023 0.023 -9999.0 0.0 -0.295 3.0 3.0 CYFIP2 0.0 0.08 -9999.0 0.0 -0.581 11.0 11.0 ENAH 0.037 0.067 -9999.0 0.0 -0.425 6.0 6.0 EGFR 0.004 0.063 -9999.0 0.0 -0.534 8.0 8.0 EPHA2 0.006 0.055 -9999.0 0.0 -0.539 6.0 6.0 MYO6 0.029 0.022 -9999.0 0.0 -0.277 3.0 3.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.014 0.06 -9999.0 0.0 -0.379 13.0 13.0 AQP5 -0.036 0.098 -9999.0 0.0 -0.467 24.0 24.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.025 -9999.0 0.0 -0.277 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.093 -9999.0 0.0 -0.283 47.0 47.0 EGF -0.178 0.251 -9999.0 0.0 -0.507 216.0 216.0 NCKAP1 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 AQP3 -0.021 0.066 -9999.0 0.0 -0.467 8.0 8.0 cortical microtubule organization 0.023 0.023 -9999.0 0.0 -0.295 3.0 3.0 GO:0000145 0.026 0.024 -9999.0 0.0 -0.265 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.023 -9999.0 0.0 -0.298 3.0 3.0 MLLT4 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 ARF6/GDP -0.005 0.039 -9999.0 0.0 -0.485 2.0 2.0 ARF6 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.045 -9999.0 0.0 -0.368 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.031 -9999.0 0.0 -0.518 2.0 2.0 ZYX 0.028 0.025 -9999.0 0.0 -0.281 1.0 1.0 ARF6/GTP 0.027 0.047 -9999.0 0.0 -0.388 6.0 6.0 CDH1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 EGFR/EGFR/EGF/EGF -0.084 0.111 -9999.0 0.0 -0.478 1.0 1.0 RhoA/GDP -0.002 0.023 -9999.0 0.0 -0.276 4.0 4.0 actin cytoskeleton organization 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.01 0.024 -9999.0 0.0 -0.58 1.0 1.0 GIT1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 IGF1R 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 IGF1 -0.073 0.197 -9999.0 0.0 -0.525 94.0 94.0 DIAPH1 -0.014 0.092 -9999.0 0.0 -0.62 13.0 13.0 Wnt receptor signaling pathway -0.023 0.023 0.295 3.0 -9999.0 0.0 3.0 RHOA 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 RhoA/GTP -0.005 0.039 -9999.0 0.0 -0.482 2.0 2.0 CTNNA1 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 VCL 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.011 0.019 -9999.0 0.0 -0.455 1.0 1.0 LPP 0.032 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.003 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.003 0.094 -9999.0 0.0 -0.287 47.0 47.0 HGF/MET -0.023 0.072 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.037 0.157 -9999.0 0.0 -0.542 52.0 52.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.036 -9999.0 0.0 -0.257 10.0 10.0 actin cable formation 0.051 0.057 -9999.0 0.0 -0.404 3.0 3.0 KIAA1543 0.031 0.034 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.024 0.041 -9999.0 0.0 -0.28 9.0 9.0 NCK1 0.009 0.034 -9999.0 0.0 -0.581 2.0 2.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.029 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.015 0.031 -9999.0 0.0 -0.421 3.0 3.0 mol:GDP 0.023 0.023 -9999.0 0.0 -0.295 3.0 3.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.022 -9999.0 0.0 -0.277 3.0 3.0 PIP5K1C 0.028 0.025 -9999.0 0.0 -0.281 1.0 1.0 LIMA1 0.004 0.064 -9999.0 0.0 -0.581 7.0 7.0 ABI1 0.01 0.024 -9999.0 0.0 -0.581 1.0 1.0 ROCK1 0.039 0.059 -9999.0 0.0 -0.472 4.0 4.0 adherens junction assembly 0.038 0.067 -9999.0 0.0 -1.069 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.038 0.089 -9999.0 0.0 -0.554 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.014 0.034 -9999.0 0.0 -0.395 4.0 4.0 MET 0.01 0.031 -9999.0 0.0 -0.518 2.0 2.0 PLEKHA7 0.028 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.023 0.045 -9999.0 0.0 -0.366 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.045 0.029 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.021 0.036 -9999.0 0.0 -0.255 10.0 10.0 regulation of cell-cell adhesion 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.036 -9999.0 0.0 -0.257 10.0 10.0