E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.013 0.04 -9999.0 0.0 -0.361 3.0 3.0 KLHL20 0.035 0.084 0.197 34.0 -0.23 26.0 60.0 CYFIP2 0.017 0.061 -9999.0 0.0 -0.445 10.0 10.0 Rac1/GDP 0.057 0.087 0.283 6.0 -0.341 2.0 8.0 ENAH 0.009 0.05 -9999.0 0.0 -0.368 4.0 4.0 AP1M1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.011 0.031 -9999.0 0.0 -0.314 1.0 1.0 ABI1/Sra1/Nap1 -0.012 0.039 -9999.0 0.0 -0.169 28.0 28.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.053 -9999.0 0.0 -0.239 14.0 14.0 RAPGEF1 0.052 0.085 0.26 6.0 -0.349 3.0 9.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.024 0.04 -9999.0 0.0 -0.368 3.0 3.0 CRK 0.054 0.082 -9999.0 0.0 -0.364 2.0 2.0 E-cadherin/gamma catenin/alpha catenin 0.048 0.029 -9999.0 0.0 -0.273 4.0 4.0 alphaE/beta7 Integrin 0.025 0.058 -9999.0 0.0 -0.309 16.0 16.0 IQGAP1 0.023 0.028 -9999.0 0.0 -0.445 2.0 2.0 NCKAP1 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 Rap1/GTP/I-afadin 0.046 0.021 -9999.0 0.0 -0.247 2.0 2.0 DLG1 0.012 0.043 -9999.0 0.0 -0.361 3.0 3.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.021 -9999.0 0.0 -0.223 2.0 2.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.032 0.066 -9999.0 0.0 -0.245 28.0 28.0 PI3K -0.013 0.027 -9999.0 0.0 -0.29 2.0 2.0 ARF6 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.036 0.022 -9999.0 0.0 -0.32 2.0 2.0 TIAM1 0.006 0.103 -9999.0 0.0 -0.445 28.0 28.0 E-cadherin(dimer)/Ca2+ 0.057 0.026 -9999.0 0.0 -0.235 3.0 3.0 AKT1 0.017 0.049 -9999.0 0.0 -0.226 2.0 2.0 PIK3R1 0.023 0.028 -9999.0 0.0 -0.445 2.0 2.0 CDH1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 RhoA/GDP 0.069 0.091 0.299 9.0 -0.341 2.0 11.0 actin cytoskeleton organization 0.031 0.066 0.164 39.0 -0.167 26.0 65.0 CDC42/GDP 0.064 0.092 0.298 10.0 -0.341 2.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.02 -9999.0 0.0 -0.225 4.0 4.0 ITGB7 0.014 0.078 -9999.0 0.0 -0.445 16.0 16.0 RAC1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.062 0.027 -9999.0 0.0 -0.251 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.043 0.022 -9999.0 0.0 -0.232 3.0 3.0 mol:GDP 0.061 0.099 0.309 11.0 -0.398 2.0 13.0 CDC42/GTP/IQGAP1 0.029 0.037 -9999.0 0.0 -0.386 4.0 4.0 JUP 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 p120 catenin/RhoA/GDP 0.078 0.092 0.302 9.0 -0.348 2.0 11.0 RAC1/GTP/IQGAP1 0.029 0.021 -9999.0 0.0 -0.269 2.0 2.0 PIP5K1C/AP1M1 0.037 0.026 -9999.0 0.0 -0.576 1.0 1.0 RHOA 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 CDC42 0.021 0.039 -9999.0 0.0 -0.445 4.0 4.0 CTNNA1 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.028 0.051 0.135 46.0 -0.115 21.0 67.0 NME1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.012 0.041 -9999.0 0.0 -0.361 3.0 3.0 regulation of cell-cell adhesion 0.006 0.025 -9999.0 0.0 -0.23 2.0 2.0 WASF2 0.008 0.031 -9999.0 0.0 -0.114 5.0 5.0 Rap1/GTP 0.072 0.077 0.299 4.0 -0.353 1.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.057 -9999.0 0.0 -0.23 16.0 16.0 CCND1 0.032 0.059 0.153 44.0 -0.14 21.0 65.0 VAV2 0.049 0.183 0.402 1.0 -0.657 29.0 30.0 RAP1/GDP 0.078 0.087 0.307 8.0 -0.398 1.0 9.0 adherens junction assembly 0.012 0.04 -9999.0 0.0 -0.351 3.0 3.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 PIP5K1C 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.042 0.051 -9999.0 0.0 -0.223 16.0 16.0 E-cadherin/beta catenin 0.011 0.02 -9999.0 0.0 -0.298 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.007 0.035 -9999.0 0.0 -0.361 3.0 3.0 PIK3CA 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 Rac1/GTP -0.013 0.086 -9999.0 0.0 -0.378 26.0 26.0 E-cadherin/beta catenin/alpha catenin 0.049 0.025 -9999.0 0.0 -0.273 3.0 3.0 ITGAE 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.024 0.041 -9999.0 0.0 -0.375 3.0 3.0