Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.032 0.167 -9999.0 0.0 -0.568 43.0 43.0 IHH -0.012 0.136 -9999.0 0.0 -0.471 42.0 42.0 SHH Np/Cholesterol/GAS1 -0.019 0.11 0.186 2.0 -0.256 99.0 101.0 LRPAP1 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 dorsoventral neural tube patterning 0.02 0.109 0.255 99.0 -0.184 2.0 101.0 SMO/beta Arrestin2 -0.023 0.162 -9999.0 0.0 -0.46 48.0 48.0 SMO -0.037 0.162 -9999.0 0.0 -0.482 48.0 48.0 AKT1 -0.027 0.147 -9999.0 0.0 -0.438 42.0 42.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.068 -9999.0 0.0 -0.445 11.0 11.0 ADRBK1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 heart looping -0.035 0.16 -9999.0 0.0 -0.474 48.0 48.0 STIL -0.024 0.126 -9999.0 0.0 -0.337 55.0 55.0 DHH N/PTCH2 0.006 0.111 -9999.0 0.0 -0.341 51.0 51.0 DHH N/PTCH1 -0.014 0.136 -9999.0 0.0 -0.295 99.0 99.0 PIK3CA 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 DHH 0.001 0.105 -9999.0 0.0 -0.445 30.0 30.0 PTHLH -0.057 0.242 -9999.0 0.0 -0.79 48.0 48.0 determination of left/right symmetry -0.035 0.16 -9999.0 0.0 -0.474 48.0 48.0 PIK3R1 0.023 0.028 -9999.0 0.0 -0.445 2.0 2.0 skeletal system development -0.056 0.239 -9999.0 0.0 -0.78 48.0 48.0 IHH N/Hhip -0.026 0.156 -9999.0 0.0 -0.372 92.0 92.0 DHH N/Hhip -0.016 0.142 -9999.0 0.0 -0.348 86.0 86.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.16 -9999.0 0.0 -0.474 48.0 48.0 pancreas development -0.024 0.15 -9999.0 0.0 -0.444 65.0 65.0 HHAT 0.02 0.048 -9999.0 0.0 -0.445 6.0 6.0 PI3K 0.034 0.031 -9999.0 0.0 -0.321 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.025 0.163 -9999.0 0.0 -0.445 75.0 75.0 somite specification -0.035 0.16 -9999.0 0.0 -0.474 48.0 48.0 SHH Np/Cholesterol/PTCH1 -0.023 0.126 -9999.0 0.0 -0.302 86.0 86.0 SHH Np/Cholesterol/PTCH2 -0.003 0.082 -9999.0 0.0 -0.254 53.0 53.0 SHH Np/Cholesterol/Megalin 0.008 0.065 0.186 1.0 -0.251 32.0 33.0 SHH -0.027 0.069 0.234 1.0 -0.32 30.0 31.0 catabolic process -0.019 0.125 -9999.0 0.0 -0.325 76.0 76.0 SMO/Vitamin D3 -0.031 0.152 -9999.0 0.0 -0.385 72.0 72.0 SHH Np/Cholesterol/Hhip -0.018 0.108 0.186 2.0 -0.27 85.0 87.0 LRP2 0.011 0.033 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.035 0.147 -9999.0 0.0 -0.451 44.0 44.0 SHH Np/Cholesterol/BOC 0.007 0.075 0.186 2.0 -0.259 39.0 41.0 SHH Np/Cholesterol/CDO 0.006 0.069 -9999.0 0.0 -0.259 35.0 35.0 mesenchymal cell differentiation 0.018 0.108 0.269 85.0 -0.184 2.0 87.0 mol:Vitamin D3 -0.015 0.136 0.364 1.0 -0.303 86.0 87.0 IHH N/PTCH2 -0.002 0.121 -9999.0 0.0 -0.34 60.0 60.0 CDON 0.021 0.048 -9999.0 0.0 -0.445 6.0 6.0 IHH N/PTCH1 -0.008 0.129 -9999.0 0.0 -0.327 76.0 76.0 Megalin/LRPAP1 0.038 0.022 -9999.0 0.0 -0.324 1.0 1.0 PTCH2 0.007 0.096 -9999.0 0.0 -0.445 25.0 25.0 SHH Np/Cholesterol -0.001 0.058 -9999.0 0.0 -0.242 32.0 32.0 PTCH1 -0.019 0.125 -9999.0 0.0 -0.326 76.0 76.0 HHIP -0.024 0.15 -9999.0 0.0 -0.445 65.0 65.0