Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.034 -9999.0 0.0 -0.233 10.0 10.0 epithelial cell differentiation 0.052 0.024 -9999.0 0.0 -0.233 3.0 3.0 CYFIP2 0.017 0.061 -9999.0 0.0 -0.445 10.0 10.0 ENAH -0.025 0.049 0.265 2.0 -0.387 4.0 6.0 EGFR 0.02 0.044 -9999.0 0.0 -0.445 5.0 5.0 EPHA2 0.023 0.028 -9999.0 0.0 -0.445 2.0 2.0 MYO6 -0.016 0.021 0.172 3.0 -0.227 3.0 6.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.051 -9999.0 0.0 -0.293 12.0 12.0 AQP5 -0.01 0.094 -9999.0 0.0 -0.45 24.0 24.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.016 0.025 0.171 5.0 -0.224 4.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.059 0.18 5.0 -0.231 40.0 45.0 EGF -0.031 0.173 -9999.0 0.0 -0.445 84.0 84.0 NCKAP1 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 AQP3 0.003 0.057 -9999.0 0.0 -0.441 8.0 8.0 cortical microtubule organization 0.052 0.024 -9999.0 0.0 -0.233 3.0 3.0 GO:0000145 -0.015 0.024 0.158 5.0 -0.214 4.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.057 0.026 -9999.0 0.0 -0.235 3.0 3.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 ARF6/GDP -0.027 0.029 -9999.0 0.0 -0.393 2.0 2.0 ARF6 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.038 -9999.0 0.0 -0.305 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.005 0.02 0.166 1.0 -0.231 1.0 2.0 PVRL2 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 ZYX -0.017 0.02 0.172 1.0 -0.227 4.0 5.0 ARF6/GTP 0.06 0.044 -9999.0 0.0 -0.335 4.0 4.0 CDH1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 EGFR/EGFR/EGF/EGF 0.008 0.097 -9999.0 0.0 -0.224 81.0 81.0 RhoA/GDP 0.052 0.027 -9999.0 0.0 -0.226 4.0 4.0 actin cytoskeleton organization -0.017 0.022 0.159 2.0 -0.219 5.0 7.0 IGF-1R heterotetramer 0.024 0.02 -9999.0 0.0 -0.444 1.0 1.0 GIT1 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 IGF1R 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 IGF1 -0.011 0.137 -9999.0 0.0 -0.445 52.0 52.0 DIAPH1 0.025 0.134 -9999.0 0.0 -0.577 24.0 24.0 Wnt receptor signaling pathway -0.052 0.024 0.233 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 RhoA/GTP -0.028 0.029 -9999.0 0.0 -0.265 7.0 7.0 CTNNA1 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 VCL -0.018 0.022 0.16 2.0 -0.223 5.0 7.0 EFNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.018 0.025 0.163 5.0 -0.221 4.0 9.0 Ephrin A1/EPHA2 0.043 0.031 -9999.0 0.0 -0.224 5.0 5.0 SEC6/SEC8 -0.024 0.02 -9999.0 0.0 -0.218 5.0 5.0 MGAT3 -0.03 0.06 0.181 5.0 -0.234 40.0 45.0 HGF/MET 0.03 0.066 -9999.0 0.0 -0.223 35.0 35.0 HGF 0.001 0.108 -9999.0 0.0 -0.445 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.034 -9999.0 0.0 -0.234 10.0 10.0 actin cable formation -0.01 0.072 0.233 16.0 -0.306 9.0 25.0 KIAA1543 -0.015 0.024 0.159 5.0 -0.217 4.0 9.0 KIFC3 -0.019 0.028 0.172 1.0 -0.228 9.0 10.0 NCK1 0.024 0.028 -9999.0 0.0 -0.445 2.0 2.0 EXOC3 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.015 0.024 0.172 5.0 -0.227 3.0 8.0 NCK1/GIT1 0.035 0.027 -9999.0 0.0 -0.32 3.0 3.0 mol:GDP 0.052 0.024 -9999.0 0.0 -0.233 3.0 3.0 EXOC4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.02 0.172 2.0 -0.227 3.0 5.0 PIP5K1C -0.016 0.026 0.172 5.0 -0.227 4.0 9.0 LIMA1 0.02 0.051 -9999.0 0.0 -0.445 7.0 7.0 ABI1 0.025 0.02 -9999.0 0.0 -0.445 1.0 1.0 ROCK1 -0.02 0.051 0.285 4.0 -0.428 2.0 6.0 adherens junction assembly -0.007 0.058 0.267 4.0 -0.398 6.0 10.0 IGF-1R heterotetramer/IGF1 0.023 0.081 -9999.0 0.0 -0.226 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.022 -9999.0 0.0 -0.32 2.0 2.0 MET 0.024 0.02 -9999.0 0.0 -0.445 1.0 1.0 PLEKHA7 -0.016 0.026 0.172 5.0 -0.227 4.0 9.0 mol:GTP 0.055 0.038 -9999.0 0.0 -0.304 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.016 0.052 0.312 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.017 0.034 -9999.0 0.0 -0.233 10.0 10.0 regulation of cell-cell adhesion -0.017 0.022 0.159 2.0 -0.219 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.034 -9999.0 0.0 -0.234 10.0 10.0