Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.008 0.155 -9999.0 0.0 -0.659 9.0 9.0 IHH 0.023 0.102 -9999.0 0.0 -0.557 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.071 0.135 -9999.0 0.0 -0.286 50.0 50.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.134 0.285 50.0 -9999.0 0.0 50.0 SMO/beta Arrestin2 0.002 0.156 -9999.0 0.0 -0.568 9.0 9.0 SMO -0.012 0.155 -9999.0 0.0 -0.599 9.0 9.0 AKT1 -0.015 0.16 -9999.0 0.0 -0.549 10.0 10.0 ARRB2 0.027 0.037 -9999.0 0.0 -0.467 1.0 1.0 BOC 0.028 0.05 -9999.0 0.0 -0.228 7.0 7.0 ADRBK1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.152 -9999.0 0.0 -0.587 9.0 9.0 STIL -0.006 0.127 0.364 1.0 -0.403 9.0 10.0 DHH N/PTCH2 0.053 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.032 0.12 -9999.0 0.0 -0.432 10.0 10.0 PIK3CA 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.005 0.204 -9999.0 0.0 -0.912 9.0 9.0 determination of left/right symmetry -0.011 0.152 -9999.0 0.0 -0.587 9.0 9.0 PIK3R1 0.029 0.059 -9999.0 0.0 -0.467 3.0 3.0 skeletal system development -0.005 0.202 -9999.0 0.0 -0.899 9.0 9.0 IHH N/Hhip -0.015 0.16 -9999.0 0.0 -0.395 29.0 29.0 DHH N/Hhip -0.003 0.13 -9999.0 0.0 -0.336 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.152 -9999.0 0.0 -0.587 9.0 9.0 pancreas development -0.036 0.167 -9999.0 0.0 -0.384 37.0 37.0 HHAT -0.0 0.123 -9999.0 0.0 -0.39 18.0 18.0 PI3K 0.047 0.047 -9999.0 0.0 -0.336 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.115 0.196 -9999.0 0.0 -0.316 92.0 92.0 somite specification -0.011 0.152 -9999.0 0.0 -0.587 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.002 0.121 -9999.0 0.0 -0.436 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.01 0.077 -9999.0 0.0 -0.263 14.0 14.0 SHH Np/Cholesterol/Megalin 0.009 0.078 -9999.0 0.0 -0.264 14.0 14.0 SHH -0.01 0.091 -9999.0 0.0 -0.343 14.0 14.0 catabolic process 0.014 0.126 -9999.0 0.0 -0.476 10.0 10.0 SMO/Vitamin D3 -0.011 0.143 -9999.0 0.0 -0.522 9.0 9.0 SHH Np/Cholesterol/Hhip -0.03 0.126 -9999.0 0.0 -0.294 35.0 35.0 LRP2 0.035 0.022 -9999.0 0.0 -0.189 2.0 2.0 receptor-mediated endocytosis -0.016 0.142 -9999.0 0.0 -0.542 8.0 8.0 SHH Np/Cholesterol/BOC 0.006 0.079 -9999.0 0.0 -0.264 14.0 14.0 SHH Np/Cholesterol/CDO 0.009 0.078 -9999.0 0.0 -0.264 14.0 14.0 mesenchymal cell differentiation 0.03 0.125 0.292 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.007 0.131 0.386 1.0 -0.439 8.0 9.0 IHH N/PTCH2 0.043 0.067 -9999.0 0.0 -0.341 5.0 5.0 CDON 0.034 0.022 -9999.0 0.0 -0.189 2.0 2.0 IHH N/PTCH1 0.025 0.13 -9999.0 0.0 -0.48 10.0 10.0 Megalin/LRPAP1 0.051 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.002 0.072 -9999.0 0.0 -0.262 14.0 14.0 PTCH1 0.014 0.126 -9999.0 0.0 -0.478 10.0 10.0 HHIP -0.036 0.167 -9999.0 0.0 -0.384 37.0 37.0