Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.072 -9999.0 0.0 -0.224 17.0 17.0 epithelial cell differentiation 0.047 0.087 -9999.0 0.0 -0.249 14.0 14.0 CYFIP2 0.012 0.107 -9999.0 0.0 -0.442 11.0 11.0 ENAH -0.041 0.081 0.277 1.0 -0.346 5.0 6.0 EGFR 0.017 0.085 -9999.0 0.0 -0.397 8.0 8.0 EPHA2 0.013 0.083 -9999.0 0.0 -0.263 15.0 15.0 MYO6 -0.008 0.074 -9999.0 0.0 -0.24 18.0 18.0 CTNNB1 0.017 0.081 -9999.0 0.0 -0.274 13.0 13.0 ABI1/Sra1/Nap1 0.047 0.088 -9999.0 0.0 -0.294 11.0 11.0 AQP5 -0.011 0.091 -9999.0 0.0 -0.488 4.0 4.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.002 0.069 -9999.0 0.0 -0.238 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.094 -9999.0 0.0 -0.239 32.0 32.0 EGF -0.087 0.182 -9999.0 0.0 -0.303 78.0 78.0 NCKAP1 0.024 0.064 -9999.0 0.0 -0.244 10.0 10.0 AQP3 -0.024 0.109 -9999.0 0.0 -0.452 8.0 8.0 cortical microtubule organization 0.047 0.087 -9999.0 0.0 -0.249 14.0 14.0 GO:0000145 -0.025 0.059 0.165 3.0 -0.227 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.09 -9999.0 0.0 -0.251 14.0 14.0 MLLT4 0.024 0.076 -9999.0 0.0 -0.467 5.0 5.0 ARF6/GDP -0.05 0.085 -9999.0 0.0 -0.354 8.0 8.0 ARF6 0.029 0.049 -9999.0 0.0 -0.467 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.096 -9999.0 0.0 -0.275 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.07 -9999.0 0.0 -0.278 6.0 6.0 PVRL2 0.031 0.041 -9999.0 0.0 -0.281 3.0 3.0 ZYX -0.007 0.069 -9999.0 0.0 -0.24 16.0 16.0 ARF6/GTP 0.048 0.102 -9999.0 0.0 -0.264 14.0 14.0 CDH1 0.012 0.106 -9999.0 0.0 -0.467 10.0 10.0 EGFR/EGFR/EGF/EGF -0.037 0.133 -9999.0 0.0 -0.26 44.0 44.0 RhoA/GDP 0.049 0.085 -9999.0 0.0 -0.239 14.0 14.0 actin cytoskeleton organization -0.031 0.063 -9999.0 0.0 -0.234 17.0 17.0 IGF-1R heterotetramer 0.031 0.038 -9999.0 0.0 -0.327 2.0 2.0 GIT1 0.034 0.017 -9999.0 0.0 -0.189 1.0 1.0 IGF1R 0.031 0.038 -9999.0 0.0 -0.328 2.0 2.0 IGF1 0.017 0.077 -9999.0 0.0 -0.244 15.0 15.0 DIAPH1 0.027 0.18 -9999.0 0.0 -0.628 13.0 13.0 Wnt receptor signaling pathway -0.047 0.087 0.249 14.0 -9999.0 0.0 14.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.082 -9999.0 0.0 -0.385 6.0 6.0 CTNNA1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.064 -9999.0 0.0 -0.237 18.0 18.0 EFNA1 0.023 0.073 -9999.0 0.0 -0.348 7.0 7.0 LPP -0.026 0.061 0.172 3.0 -0.233 14.0 17.0 Ephrin A1/EPHA2 0.019 0.112 -9999.0 0.0 -0.29 19.0 19.0 SEC6/SEC8 -0.009 0.085 -9999.0 0.0 -0.344 8.0 8.0 MGAT3 -0.036 0.095 -9999.0 0.0 -0.242 32.0 32.0 HGF/MET 0.034 0.091 -9999.0 0.0 -0.254 15.0 15.0 HGF 0.033 0.023 -9999.0 0.0 -0.189 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.073 -9999.0 0.0 -0.226 17.0 17.0 actin cable formation -0.019 0.103 0.326 5.0 -0.299 8.0 13.0 KIAA1543 -0.025 0.06 0.166 3.0 -0.23 14.0 17.0 KIFC3 -0.007 0.069 -9999.0 0.0 -0.241 15.0 15.0 NCK1 0.027 0.068 -9999.0 0.0 -0.467 4.0 4.0 EXOC3 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.069 -9999.0 0.0 -0.241 14.0 14.0 NCK1/GIT1 0.043 0.055 -9999.0 0.0 -0.336 4.0 4.0 mol:GDP 0.047 0.087 -9999.0 0.0 -0.249 14.0 14.0 EXOC4 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.005 0.068 -9999.0 0.0 -0.241 15.0 15.0 PIP5K1C -0.002 0.069 -9999.0 0.0 -0.241 14.0 14.0 LIMA1 0.025 0.071 -9999.0 0.0 -0.374 6.0 6.0 ABI1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.032 0.089 0.299 3.0 -0.385 4.0 7.0 adherens junction assembly -0.007 0.071 0.269 3.0 -0.315 1.0 4.0 IGF-1R heterotetramer/IGF1 0.025 0.094 -9999.0 0.0 -0.242 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.067 -9999.0 0.0 -0.336 6.0 6.0 MET 0.028 0.053 -9999.0 0.0 -0.328 4.0 4.0 PLEKHA7 -0.002 0.069 -9999.0 0.0 -0.241 14.0 14.0 mol:GTP 0.046 0.095 -9999.0 0.0 -0.273 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.025 0.094 0.328 1.0 -0.366 6.0 7.0 cortical actin cytoskeleton stabilization 0.01 0.072 -9999.0 0.0 -0.224 17.0 17.0 regulation of cell-cell adhesion -0.031 0.063 -9999.0 0.0 -0.234 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.073 -9999.0 0.0 -0.226 17.0 17.0