Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.052 0.174 -9999.0 0.0 -0.374 5.0 5.0 epithelial cell differentiation -0.07 0.133 -9999.0 0.0 -0.348 5.0 5.0 CYFIP2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.006 0.128 -9999.0 0.0 -0.47 1.0 1.0 EGFR -0.057 0.186 -9999.0 0.0 -0.481 4.0 4.0 EPHA2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.072 0.156 -9999.0 0.0 -0.35 6.0 6.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.012 0.082 -9999.0 0.0 -0.414 1.0 1.0 AQP5 -0.061 0.108 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.038 0.137 -9999.0 0.0 -0.322 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.076 0.184 -9999.0 0.0 -0.372 7.0 7.0 EGF 0.005 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 -0.01 0.125 -9999.0 0.0 -0.661 1.0 1.0 AQP3 -0.086 0.153 -9999.0 0.0 -0.411 4.0 4.0 cortical microtubule organization -0.07 0.133 -9999.0 0.0 -0.348 5.0 5.0 GO:0000145 -0.037 0.131 -9999.0 0.0 -0.308 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.047 0.147 -9999.0 0.0 -0.351 5.0 5.0 MLLT4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.101 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.024 0.132 -9999.0 0.0 -0.298 5.0 5.0 PVRL2 0.002 0.058 -9999.0 0.0 -0.301 1.0 1.0 ZYX -0.039 0.139 -9999.0 0.0 -0.327 5.0 5.0 ARF6/GTP 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.129 0.261 -9999.0 0.0 -0.558 7.0 7.0 EGFR/EGFR/EGF/EGF -0.094 0.16 -9999.0 0.0 -0.371 6.0 6.0 RhoA/GDP -0.065 0.123 -9999.0 0.0 -0.324 5.0 5.0 actin cytoskeleton organization -0.066 0.148 -9999.0 0.0 -0.328 6.0 6.0 IGF-1R heterotetramer 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.046 0.18 -9999.0 0.0 -0.541 3.0 3.0 DIAPH1 -0.025 0.134 -9999.0 0.0 -0.718 1.0 1.0 Wnt receptor signaling pathway 0.07 0.133 0.348 5.0 -9999.0 0.0 5.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.102 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.068 0.151 -9999.0 0.0 -0.336 6.0 6.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.03 0.133 -9999.0 0.0 -0.306 5.0 5.0 Ephrin A1/EPHA2 -0.062 0.118 -9999.0 0.0 -0.311 5.0 5.0 SEC6/SEC8 -0.059 0.107 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.077 0.188 -9999.0 0.0 -0.378 7.0 7.0 HGF/MET -0.148 0.229 -9999.0 0.0 -0.472 7.0 7.0 HGF -0.046 0.18 -9999.0 0.0 -0.541 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.053 0.176 -9999.0 0.0 -0.378 5.0 5.0 actin cable formation 0.013 0.126 -9999.0 0.0 -0.446 1.0 1.0 KIAA1543 -0.1 0.178 -9999.0 0.0 -0.351 8.0 8.0 KIFC3 -0.052 0.149 -9999.0 0.0 -0.328 6.0 6.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.039 0.139 -9999.0 0.0 -0.327 5.0 5.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.07 0.133 -9999.0 0.0 -0.348 5.0 5.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.039 0.139 -9999.0 0.0 -0.327 5.0 5.0 PIP5K1C -0.039 0.139 -9999.0 0.0 -0.327 5.0 5.0 LIMA1 -0.022 0.136 -9999.0 0.0 -0.481 2.0 2.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.113 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.09 0.203 -9999.0 0.0 -0.642 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.089 0.159 -9999.0 0.0 -0.368 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.04 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.126 0.225 -9999.0 0.0 -0.421 9.0 9.0 PLEKHA7 -0.075 0.154 -9999.0 0.0 -0.329 7.0 7.0 mol:GTP 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.013 0.125 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.052 0.174 -9999.0 0.0 -0.374 5.0 5.0 regulation of cell-cell adhesion -0.066 0.148 -9999.0 0.0 -0.328 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.053 0.176 -9999.0 0.0 -0.378 5.0 5.0