Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	8.0	812.0	91.0	-1.058	1.006	1000.0	-1000.0	-0.124	-1000.0
IL23-mediated signaling events	6.0	414.0	60.0	-0.533	0.018	1000.0	-1000.0	-0.131	-1000.0
TCGA08_retinoblastoma	5.0	41.0	8.0	-0.138	0.043	1000.0	-1000.0	-0.01	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	149.0	34.0	-0.211	0.014	1000.0	-1000.0	-0.035	-1000.0
Syndecan-1-mediated signaling events	4.0	166.0	34.0	-0.227	0.014	1000.0	-1000.0	-0.033	-1000.0
Osteopontin-mediated events	4.0	153.0	38.0	-0.209	0.016	1000.0	-1000.0	-0.074	-1000.0
Glucocorticoid receptor regulatory network	4.0	508.0	114.0	-0.549	0.449	1000.0	-1000.0	-0.057	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	379.0	82.0	-0.293	0.014	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling events	4.0	21.0	5.0	-0.129	0.014	1000.0	-1000.0	-0.018	-1000.0
IL12-mediated signaling events	3.0	268.0	87.0	-0.276	0.133	1000.0	-1000.0	-0.109	-1000.0
Noncanonical Wnt signaling pathway	3.0	82.0	26.0	-0.094	0.014	1000.0	-1000.0	-0.042	-1000.0
p75(NTR)-mediated signaling	3.0	437.0	125.0	-0.199	0.041	1000.0	-1000.0	-0.077	-1000.0
Endothelins	3.0	344.0	96.0	-0.214	0.014	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	145.0	44.0	-0.147	0.014	1000.0	-1000.0	-0.029	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	313.0	93.0	-0.152	0.02	1000.0	-1000.0	-0.056	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	101.0	31.0	-0.359	0.014	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	3.0	21.0	7.0	-0.094	0.014	1000.0	-1000.0	-0.023	-1000.0
S1P4 pathway	3.0	81.0	25.0	-0.139	0.019	1000.0	-1000.0	-0.026	-1000.0
ErbB2/ErbB3 signaling events	2.0	137.0	65.0	-0.111	0.02	1000.0	-1000.0	-0.053	-1000.0
BARD1 signaling events	2.0	130.0	57.0	-0.185	0.124	1000.0	-1000.0	-0.054	-1000.0
Ephrin A  reverse signaling	2.0	20.0	7.0	-0.104	0.003	1000.0	-1000.0	-0.012	-1000.0
Thromboxane A2 receptor signaling	2.0	234.0	105.0	-0.07	0.019	1000.0	-1000.0	-0.054	-1000.0
Arf6 signaling events	2.0	126.0	62.0	-0.139	0.035	1000.0	-1000.0	-0.036	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	206.0	85.0	-0.126	0.014	1000.0	-1000.0	-0.053	-1000.0
Arf6 downstream pathway	2.0	121.0	43.0	-0.169	0.073	1000.0	-1000.0	-0.026	-1000.0
amb2 Integrin signaling	2.0	239.0	82.0	-0.237	0.019	1000.0	-1000.0	-0.063	-1000.0
Nectin adhesion pathway	2.0	152.0	63.0	-0.139	0.027	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	2.0	118.0	56.0	-0.115	0.027	1000.0	-1000.0	-0.054	-1000.0
S1P1 pathway	2.0	73.0	36.0	-0.14	0.014	1000.0	-1000.0	-0.054	-1000.0
TCGA08_p53	2.0	19.0	7.0	-0.106	0.066	1000.0	-1000.0	-0.01	-1000.0
Integrins in angiogenesis	2.0	237.0	84.0	-0.187	0.03	1000.0	-1000.0	-0.071	-1000.0
Canonical Wnt signaling pathway	2.0	103.0	51.0	-0.221	0.054	1000.0	-1000.0	-0.035	-1000.0
IL27-mediated signaling events	2.0	123.0	51.0	-0.203	0.094	1000.0	-1000.0	-0.065	-1000.0
LPA receptor mediated events	2.0	232.0	102.0	-0.16	0.014	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	2.0	153.0	68.0	-0.402	0.065	1000.0	-1000.0	-0.091	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	213.0	74.0	-0.148	0.07	1000.0	-1000.0	-0.073	-1000.0
Syndecan-4-mediated signaling events	2.0	147.0	67.0	-0.199	0.02	1000.0	-1000.0	-0.058	-1000.0
S1P3 pathway	2.0	93.0	42.0	-0.138	0.015	1000.0	-1000.0	-0.026	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	190.0	88.0	-0.282	0.021	1000.0	-1000.0	-0.082	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.011	-1000.0
LPA4-mediated signaling events	1.0	19.0	12.0	-0.092	0.003	1000.0	-1000.0	-0.013	-1000.0
Caspase cascade in apoptosis	1.0	107.0	74.0	-0.123	0.061	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	1.0	107.0	76.0	-0.24	0.05	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	52.0	28.0	-0.139	0.023	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	1.0	53.0	38.0	-0.092	0.014	1000.0	-1000.0	-0.045	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	73.0	54.0	-0.115	0.027	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by the Hedgehog family	1.0	102.0	52.0	-0.12	0.019	1000.0	-1000.0	-0.034	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	17.0	17.0	-0.046	0.024	1000.0	-1000.0	-0.024	-1000.0
HIF-1-alpha transcription factor network	1.0	100.0	76.0	-0.21	0.038	1000.0	-1000.0	-0.084	-1000.0
Syndecan-2-mediated signaling events	1.0	105.0	69.0	-0.187	0.043	1000.0	-1000.0	-0.023	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.046	0.014	1000.0	-1000.0	-0.009	-1000.0
Cellular roles of Anthrax toxin	1.0	50.0	39.0	-0.086	0.016	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	1.0	121.0	76.0	-0.139	0.039	1000.0	-1000.0	-0.066	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	92.0	61.0	-0.221	0.048	1000.0	-1000.0	-0.061	-1000.0
BMP receptor signaling	1.0	159.0	81.0	-0.224	0.031	1000.0	-1000.0	-0.07	-1000.0
Glypican 1 network	1.0	78.0	48.0	-0.263	0.033	1000.0	-1000.0	-0.027	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	131.0	97.0	-0.11	0.032	1000.0	-1000.0	-0.065	-1000.0
PDGFR-alpha signaling pathway	1.0	62.0	44.0	-0.133	0.023	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	48.0	37.0	-0.187	0.034	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	1.0	69.0	62.0	-0.083	0.057	1000.0	-1000.0	-0.076	-1000.0
S1P5 pathway	1.0	33.0	17.0	-0.139	0.062	1000.0	-1000.0	-0.029	-1000.0
Ephrin B reverse signaling	1.0	81.0	48.0	-0.139	0.02	1000.0	-1000.0	-0.047	-1000.0
FAS signaling pathway (CD95)	1.0	80.0	47.0	-0.126	0.049	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	21.0	15.0	-0.069	0.017	1000.0	-1000.0	-0.021	-1000.0
Syndecan-3-mediated signaling events	1.0	47.0	35.0	-0.187	0.041	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	1.0	82.0	58.0	-0.104	0.022	1000.0	-1000.0	-0.058	-1000.0
EPHB forward signaling	1.0	102.0	85.0	-0.282	0.035	1000.0	-1000.0	-0.066	-1000.0
Effects of Botulinum toxin	1.0	38.0	26.0	-0.083	0.019	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	1.0	4.0	4.0	0.002	0.006	1000.0	-1000.0	-0.015	-1000.0
Nongenotropic Androgen signaling	1.0	67.0	52.0	-0.139	0.028	1000.0	-1000.0	-0.041	-1000.0
TCGA08_rtk_signaling	1.0	31.0	26.0	-0.126	0.031	1000.0	-1000.0	-0.017	-1000.0
IL6-mediated signaling events	1.0	109.0	75.0	-0.2	0.04	1000.0	-1000.0	-0.056	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	134.0	76.0	-0.129	0.027	1000.0	-1000.0	-0.068	-1000.0
IL2 signaling events mediated by STAT5	1.0	25.0	22.0	-0.108	0.014	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	1.0	168.0	99.0	-0.105	0.041	1000.0	-1000.0	-0.066	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.067	0.02	1000.0	-1000.0	-0.054	-1000.0
IGF1 pathway	1.0	76.0	57.0	-0.053	0.028	1000.0	-1000.0	-0.069	-1000.0
Insulin Pathway	1.0	79.0	74.0	-0.099	0.027	1000.0	-1000.0	-0.066	-1000.0
Plasma membrane estrogen receptor signaling	1.0	120.0	86.0	-0.139	0.046	1000.0	-1000.0	-0.065	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	223.0	120.0	-0.201	0.149	1000.0	-1000.0	-0.058	-1000.0
Visual signal transduction: Rods	1.0	89.0	52.0	-0.168	0.014	1000.0	-1000.0	-0.073	-1000.0
E-cadherin signaling in keratinocytes	1.0	49.0	43.0	-0.129	0.017	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	109.0	78.0	-0.05	0.03	1000.0	-1000.0	-0.057	-1000.0
Regulation of Androgen receptor activity	1.0	102.0	70.0	-0.229	0.03	1000.0	-1000.0	-0.047	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	20.0	17.0	-0.016	0.025	1000.0	-1000.0	-0.026	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	94.0	136.0	-0.203	0.082	1000.0	-1000.0	-0.051	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.054	0.047	1000.0	-1000.0	-0.035	-1000.0
Canonical NF-kappaB pathway	0.0	4.0	39.0	-0.01	0.071	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class II	0.0	35.0	75.0	-0.131	0.034	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	0.0	56.0	69.0	-0.093	0.029	1000.0	-1000.0	-0.081	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.01	0.014	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.029	0.045	1000.0	-1000.0	-0.028	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	64.0	65.0	-0.139	0.051	1000.0	-1000.0	-0.057	-1000.0
Aurora A signaling	0.0	12.0	60.0	-0.034	0.04	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.027	1000.0	-1000.0	-0.024	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	41.0	46.0	-0.083	0.042	1000.0	-1000.0	-0.041	-1000.0
EPO signaling pathway	0.0	14.0	55.0	-0.059	0.046	1000.0	-1000.0	-0.071	-1000.0
PLK1 signaling events	0.0	36.0	85.0	-0.048	0.036	1000.0	-1000.0	-0.033	-1000.0
Insulin-mediated glucose transport	0.0	17.0	32.0	-0.129	0.031	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	0.0	35.0	53.0	-0.035	0.02	1000.0	-1000.0	-0.049	-1000.0
IFN-gamma pathway	0.0	51.0	68.0	-0.137	0.06	1000.0	-1000.0	-0.07	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	21.0	68.0	-0.129	0.043	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	0.0	29.0	76.0	-0.055	0.054	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	0.0	27.0	40.0	-0.083	0.025	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	0.0	6.0	48.0	-0.011	0.046	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	0.0	10.0	49.0	-0.055	0.057	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	26.0	52.0	-0.091	0.051	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	0.0	11.0	43.0	-0.154	0.157	1000.0	-1000.0	-0.061	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	78.0	83.0	-0.131	0.036	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class I	0.0	9.0	104.0	-0.035	0.055	1000.0	-1000.0	-0.042	-1000.0
FoxO family signaling	0.0	26.0	64.0	-0.129	0.072	1000.0	-1000.0	-0.046	-1000.0
Retinoic acid receptors-mediated signaling	0.0	31.0	58.0	-0.065	0.03	1000.0	-1000.0	-0.062	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	27.0	36.0	-0.046	0.028	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.031	0.043	1000.0	-1000.0	-0.022	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	30.0	45.0	-0.035	0.059	1000.0	-1000.0	-0.064	-1000.0
Regulation of p38-alpha and p38-beta	0.0	53.0	54.0	-0.139	0.035	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	69.0	125.0	-0.139	0.052	1000.0	-1000.0	-0.072	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.035	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events	0.0	47.0	73.0	-0.07	0.034	1000.0	-1000.0	-0.051	-1000.0
Arf6 trafficking events	0.0	24.0	71.0	-0.07	0.043	1000.0	-1000.0	-0.058	-1000.0
Regulation of Telomerase	0.0	48.0	102.0	-0.085	0.048	1000.0	-1000.0	-0.076	-1000.0
VEGFR1 specific signals	0.0	54.0	56.0	-0.046	0.037	1000.0	-1000.0	-0.047	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	28.0	33.0	-0.142	0.043	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	0.0	14.0	20.0	-0.035	0.014	1000.0	-1000.0	-0.013	-1000.0
PDGFR-beta signaling pathway	0.0	64.0	97.0	-0.282	0.056	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by PRL	0.0	20.0	34.0	-0.119	0.044	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	0.0	50.0	51.0	-0.147	0.152	1000.0	-1000.0	-0.141	-1000.0
p38 MAPK signaling pathway	0.0	32.0	44.0	-0.137	0.027	1000.0	-1000.0	-0.056	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.003	0.035	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.041	1000.0	-1000.0	-0.017	-1000.0
Aurora B signaling	0.0	22.0	67.0	-0.099	0.033	1000.0	-1000.0	-0.059	-1000.0
Total	159	12314	7203	-18.3168734844	-993.684751177	131000	-131000	-6.27929270292	-131000