Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.126 -9999.0 0.0 -0.339 3.0 3.0 epithelial cell differentiation 0.005 0.108 -9999.0 0.0 -0.247 4.0 4.0 CYFIP2 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.021 0.099 0.422 1.0 -9999.0 0.0 1.0 EGFR -0.011 0.128 -9999.0 0.0 -0.469 2.0 2.0 EPHA2 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.024 0.102 -9999.0 0.0 -0.226 4.0 4.0 CTNNB1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.065 -9999.0 0.0 -0.289 1.0 1.0 AQP5 -0.013 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.026 0.105 0.184 1.0 -0.236 4.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.056 0.129 -9999.0 0.0 -0.273 6.0 6.0 EGF -0.001 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.012 0.093 -9999.0 0.0 -0.469 1.0 1.0 AQP3 -0.024 0.111 -9999.0 0.0 -0.465 1.0 1.0 cortical microtubule organization 0.005 0.108 -9999.0 0.0 -0.247 4.0 4.0 GO:0000145 -0.025 0.099 0.176 1.0 -0.225 4.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.009 0.111 -9999.0 0.0 -0.249 4.0 4.0 MLLT4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.047 0.072 -9999.0 0.0 -0.221 4.0 4.0 ARF6 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.084 0.185 1.0 -0.216 2.0 3.0 PVRL2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.09 0.186 1.0 -0.239 3.0 4.0 ARF6/GTP 0.072 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.046 0.173 -9999.0 0.0 -0.469 4.0 4.0 EGFR/EGFR/EGF/EGF -0.012 0.123 -9999.0 0.0 -0.291 4.0 4.0 RhoA/GDP 0.006 0.104 -9999.0 0.0 -0.237 4.0 4.0 actin cytoskeleton organization -0.027 0.098 -9999.0 0.0 -0.22 4.0 4.0 IGF-1R heterotetramer 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.007 0.128 -9999.0 0.0 -0.469 2.0 2.0 DIAPH1 0.023 0.129 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.005 0.108 0.247 4.0 -9999.0 0.0 4.0 RHOA 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.046 0.073 -9999.0 0.0 -0.223 4.0 4.0 CTNNA1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.028 0.099 -9999.0 0.0 -0.224 4.0 4.0 EFNA1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.026 0.087 0.182 1.0 -0.231 3.0 4.0 Ephrin A1/EPHA2 0.004 0.1 -9999.0 0.0 -0.234 4.0 4.0 SEC6/SEC8 -0.034 0.052 -9999.0 0.0 -0.211 2.0 2.0 MGAT3 -0.057 0.13 -9999.0 0.0 -0.277 6.0 6.0 HGF/MET -0.001 0.105 -9999.0 0.0 -0.248 4.0 4.0 HGF 0.007 0.092 -9999.0 0.0 -0.469 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.023 0.127 -9999.0 0.0 -0.342 3.0 3.0 actin cable formation 0.017 0.13 0.428 2.0 -9999.0 0.0 2.0 KIAA1543 -0.042 0.113 0.177 1.0 -0.229 6.0 7.0 KIFC3 -0.045 0.097 -9999.0 0.0 -0.24 5.0 5.0 NCK1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.027 0.106 0.186 1.0 -0.239 4.0 5.0 NCK1/GIT1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.005 0.108 -9999.0 0.0 -0.247 4.0 4.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.033 0.099 0.186 1.0 -0.239 4.0 5.0 PIP5K1C -0.026 0.106 0.186 1.0 -0.239 4.0 5.0 LIMA1 0.009 0.092 -9999.0 0.0 -0.469 1.0 1.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.005 0.133 0.327 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.051 0.152 0.265 1.0 -0.571 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.015 0.131 -9999.0 0.0 -0.277 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.012 0.127 -9999.0 0.0 -0.469 2.0 2.0 PLEKHA7 -0.043 0.119 0.186 1.0 -0.24 6.0 7.0 mol:GTP 0.063 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.013 0.091 0.312 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.022 0.126 -9999.0 0.0 -0.339 3.0 3.0 regulation of cell-cell adhesion -0.027 0.098 -9999.0 0.0 -0.22 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.023 0.127 -9999.0 0.0 -0.342 3.0 3.0