Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.311 0.329 -9999.0 0.0 -0.747 23.0 23.0 IHH -0.225 0.267 -9999.0 0.0 -0.573 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.231 0.207 -9999.0 0.0 -0.447 27.0 27.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.229 0.205 0.443 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.274 0.291 -9999.0 0.0 -0.617 25.0 25.0 SMO -0.296 0.308 -9999.0 0.0 -0.656 25.0 25.0 AKT1 -0.109 0.115 -9999.0 0.0 -0.306 9.0 9.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.106 -9999.0 0.0 -0.513 3.0 3.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.29 0.3 -9999.0 0.0 -0.643 25.0 25.0 STIL -0.31 0.241 -9999.0 0.0 -0.52 32.0 32.0 DHH N/PTCH2 -0.048 0.161 -9999.0 0.0 -0.557 6.0 6.0 DHH N/PTCH1 -0.233 0.216 -9999.0 0.0 -0.51 24.0 24.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.042 0.187 -9999.0 0.0 -0.717 5.0 5.0 PTHLH -0.481 0.527 -9999.0 0.0 -1.197 23.0 23.0 determination of left/right symmetry -0.29 0.3 -9999.0 0.0 -0.643 25.0 25.0 PIK3R1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.472 0.515 -9999.0 0.0 -1.173 23.0 23.0 IHH N/Hhip -0.209 0.264 -9999.0 0.0 -0.534 24.0 24.0 DHH N/Hhip -0.122 0.227 -9999.0 0.0 -0.503 17.0 17.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.29 0.3 -9999.0 0.0 -0.643 25.0 25.0 pancreas development -0.107 0.25 -9999.0 0.0 -0.622 13.0 13.0 HHAT -0.021 0.147 -9999.0 0.0 -0.717 3.0 3.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.086 0.228 -9999.0 0.0 -0.606 11.0 11.0 somite specification -0.29 0.3 -9999.0 0.0 -0.643 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.333 0.254 -9999.0 0.0 -0.512 41.0 41.0 SHH Np/Cholesterol/PTCH2 -0.185 0.203 -9999.0 0.0 -0.431 25.0 25.0 SHH Np/Cholesterol/Megalin -0.23 0.254 -9999.0 0.0 -0.506 27.0 27.0 SHH -0.219 0.258 -9999.0 0.0 -0.486 33.0 33.0 catabolic process -0.223 0.238 -9999.0 0.0 -0.574 19.0 19.0 SMO/Vitamin D3 -0.36 0.288 -9999.0 0.0 -0.621 32.0 32.0 SHH Np/Cholesterol/Hhip -0.242 0.23 -9999.0 0.0 -0.472 29.0 29.0 LRP2 -0.085 0.236 -9999.0 0.0 -0.656 10.0 10.0 receptor-mediated endocytosis -0.378 0.293 -9999.0 0.0 -0.635 34.0 34.0 SHH Np/Cholesterol/BOC -0.189 0.204 -9999.0 0.0 -0.389 34.0 34.0 SHH Np/Cholesterol/CDO -0.181 0.193 -9999.0 0.0 -0.422 23.0 23.0 mesenchymal cell differentiation 0.24 0.228 0.469 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.333 0.255 -9999.0 0.0 -0.513 41.0 41.0 IHH N/PTCH2 -0.134 0.172 -9999.0 0.0 -0.385 18.0 18.0 CDON 0.003 0.062 -9999.0 0.0 -0.513 1.0 1.0 IHH N/PTCH1 -0.225 0.241 -9999.0 0.0 -0.58 19.0 19.0 Megalin/LRPAP1 -0.069 0.173 -9999.0 0.0 -0.486 10.0 10.0 PTCH2 -0.004 0.087 -9999.0 0.0 -0.513 2.0 2.0 SHH Np/Cholesterol -0.181 0.197 -9999.0 0.0 -0.384 33.0 33.0 PTCH1 -0.223 0.239 -9999.0 0.0 -0.576 19.0 19.0 HHIP -0.107 0.25 -9999.0 0.0 -0.623 13.0 13.0