Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	24.0	192.0	8.0	-0.321	0.133	1000.0	-1000.0	-0.027	-1000.0
FOXA2 and FOXA3 transcription factor networks	19.0	899.0	46.0	-0.817	0.009	1000.0	-1000.0	-0.109	-1000.0
Signaling events mediated by the Hedgehog family	18.0	937.0	52.0	-0.481	0.24	1000.0	-1000.0	-0.08	-1000.0
IL23-mediated signaling events	10.0	651.0	60.0	-0.473	0.011	1000.0	-1000.0	-0.177	-1000.0
Ephrin A  reverse signaling	9.0	68.0	7.0	-0.089	0.0	1000.0	-1000.0	-0.031	-1000.0
TCGA08_p53	9.0	67.0	7.0	-0.248	0.134	1000.0	-1000.0	-0.018	-1000.0
p75(NTR)-mediated signaling	8.0	1007.0	125.0	-0.265	0.011	1000.0	-1000.0	-0.105	-1000.0
IL4-mediated signaling events	8.0	770.0	91.0	-0.72	0.496	1000.0	-1000.0	-0.177	-1000.0
Glypican 1 network	8.0	425.0	48.0	-0.295	0.067	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.073	-1000.0	1000.0	-1000.0	-0.015	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	259.0	34.0	-0.149	0.011	1000.0	-1000.0	-0.069	-1000.0
S1P5 pathway	7.0	121.0	17.0	-0.236	0.131	1000.0	-1000.0	-0.051	-1000.0
Ephrin B reverse signaling	7.0	372.0	48.0	-0.173	0.101	1000.0	-1000.0	-0.077	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	331.0	44.0	-0.172	0.011	1000.0	-1000.0	-0.053	-1000.0
Syndecan-4-mediated signaling events	7.0	480.0	67.0	-0.211	0.035	1000.0	-1000.0	-0.093	-1000.0
Syndecan-1-mediated signaling events	6.0	233.0	34.0	-0.162	0.011	1000.0	-1000.0	-0.072	-1000.0
BMP receptor signaling	6.0	496.0	81.0	-0.291	0.031	1000.0	-1000.0	-0.099	-1000.0
Glucocorticoid receptor regulatory network	6.0	720.0	114.0	-0.626	0.289	1000.0	-1000.0	-0.078	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	601.0	93.0	-0.138	0.072	1000.0	-1000.0	-0.095	-1000.0
Glypican 2 network	6.0	24.0	4.0	-0.054	-1000.0	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	6.0	45.0	7.0	-0.106	-0.015	1000.0	-1000.0	-0.034	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	421.0	68.0	-0.311	0.083	1000.0	-1000.0	-0.129	-1000.0
Osteopontin-mediated events	5.0	221.0	38.0	-0.185	0.012	1000.0	-1000.0	-0.107	-1000.0
HIF-1-alpha transcription factor network	5.0	431.0	76.0	-0.324	0.027	1000.0	-1000.0	-0.182	-1000.0
amb2 Integrin signaling	5.0	470.0	82.0	-0.176	0.011	1000.0	-1000.0	-0.083	-1000.0
Signaling events regulated by Ret tyrosine kinase	5.0	413.0	82.0	-0.144	0.011	1000.0	-1000.0	-0.091	-1000.0
Endothelins	5.0	495.0	96.0	-0.299	0.018	1000.0	-1000.0	-0.097	-1000.0
LPA receptor mediated events	5.0	533.0	102.0	-0.195	0.03	1000.0	-1000.0	-0.097	-1000.0
Visual signal transduction: Rods	5.0	306.0	52.0	-0.292	0.011	1000.0	-1000.0	-0.093	-1000.0
IL12-mediated signaling events	4.0	433.0	87.0	-0.215	0.039	1000.0	-1000.0	-0.134	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	113.0	28.0	-0.236	0.011	1000.0	-1000.0	-0.06	-1000.0
Visual signal transduction: Cones	4.0	173.0	38.0	-0.185	0.011	1000.0	-1000.0	-0.062	-1000.0
EPHB forward signaling	4.0	382.0	85.0	-0.146	0.116	1000.0	-1000.0	-0.102	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	143.0	31.0	-0.249	0.012	1000.0	-1000.0	-0.094	-1000.0
BCR signaling pathway	4.0	466.0	99.0	-0.164	0.011	1000.0	-1000.0	-0.095	-1000.0
EGFR-dependent Endothelin signaling events	4.0	103.0	21.0	-0.138	0.011	1000.0	-1000.0	-0.073	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	562.0	120.0	-0.387	0.142	1000.0	-1000.0	-0.083	-1000.0
ErbB4 signaling events	3.0	250.0	69.0	-0.235	0.063	1000.0	-1000.0	-0.092	-1000.0
Noncanonical Wnt signaling pathway	3.0	99.0	26.0	-0.106	0.011	1000.0	-1000.0	-0.085	-1000.0
Thromboxane A2 receptor signaling	3.0	359.0	105.0	-0.133	0.025	1000.0	-1000.0	-0.078	-1000.0
Syndecan-2-mediated signaling events	3.0	264.0	69.0	-0.162	0.036	1000.0	-1000.0	-0.062	-1000.0
Arf6 signaling events	3.0	234.0	62.0	-0.138	0.015	1000.0	-1000.0	-0.073	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	205.0	65.0	-0.444	0.043	1000.0	-1000.0	-0.064	-1000.0
EPO signaling pathway	3.0	208.0	55.0	-0.189	0.011	1000.0	-1000.0	-0.104	-1000.0
IL1-mediated signaling events	3.0	227.0	62.0	-0.187	0.053	1000.0	-1000.0	-0.093	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	164.0	52.0	-0.158	0.022	1000.0	-1000.0	-0.065	-1000.0
S1P1 pathway	3.0	142.0	36.0	-0.11	0.011	1000.0	-1000.0	-0.059	-1000.0
Syndecan-3-mediated signaling events	3.0	111.0	35.0	-0.123	0.011	1000.0	-1000.0	-0.072	-1000.0
Canonical Wnt signaling pathway	3.0	157.0	51.0	-0.174	0.034	1000.0	-1000.0	-0.062	-1000.0
Effects of Botulinum toxin	3.0	84.0	26.0	-0.12	0.015	1000.0	-1000.0	-0.067	-1000.0
IL27-mediated signaling events	3.0	179.0	51.0	-0.198	0.038	1000.0	-1000.0	-0.082	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	108.0	33.0	-0.328	0.031	1000.0	-1000.0	-0.066	-1000.0
S1P4 pathway	3.0	99.0	25.0	-0.236	0.016	1000.0	-1000.0	-0.061	-1000.0
LPA4-mediated signaling events	2.0	35.0	12.0	-0.045	0.018	1000.0	-1000.0	-0.032	-1000.0
ErbB2/ErbB3 signaling events	2.0	145.0	65.0	-0.11	0.039	1000.0	-1000.0	-0.072	-1000.0
Caspase cascade in apoptosis	2.0	183.0	74.0	-0.098	0.031	1000.0	-1000.0	-0.062	-1000.0
Coregulation of Androgen receptor activity	2.0	188.0	76.0	-0.387	0.021	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PTP1B	2.0	203.0	76.0	-0.139	0.015	1000.0	-1000.0	-0.087	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	156.0	61.0	-0.173	0.031	1000.0	-1000.0	-0.072	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	276.0	97.0	-0.193	0.024	1000.0	-1000.0	-0.103	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	106.0	37.0	-0.193	0.011	1000.0	-1000.0	-0.085	-1000.0
Reelin signaling pathway	2.0	152.0	56.0	-0.127	0.018	1000.0	-1000.0	-0.084	-1000.0
FAS signaling pathway (CD95)	2.0	118.0	47.0	-0.117	0.011	1000.0	-1000.0	-0.055	-1000.0
Retinoic acid receptors-mediated signaling	2.0	122.0	58.0	-0.136	0.015	1000.0	-1000.0	-0.08	-1000.0
IL2 signaling events mediated by PI3K	2.0	125.0	58.0	-0.149	0.024	1000.0	-1000.0	-0.094	-1000.0
Integrins in angiogenesis	2.0	220.0	84.0	-0.187	0.017	1000.0	-1000.0	-0.09	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	150.0	74.0	-0.207	0.046	1000.0	-1000.0	-0.107	-1000.0
IGF1 pathway	2.0	116.0	57.0	-0.055	0.011	1000.0	-1000.0	-0.099	-1000.0
S1P3 pathway	2.0	103.0	42.0	-0.064	0.017	1000.0	-1000.0	-0.062	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	180.0	88.0	-0.11	0.062	1000.0	-1000.0	-0.12	-1000.0
Regulation of Androgen receptor activity	2.0	178.0	70.0	-0.39	0.024	1000.0	-1000.0	-0.066	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	264.0	136.0	-0.265	0.093	1000.0	-1000.0	-0.082	-1000.0
Circadian rhythm pathway	1.0	22.0	22.0	-0.057	0.034	1000.0	-1000.0	-0.059	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	71.0	54.0	-0.084	0.02	1000.0	-1000.0	-0.101	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	29.0	17.0	-0.031	0.024	1000.0	-1000.0	-0.074	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	5.0	5.0	-0.013	0.003	1000.0	-1000.0	-0.04	-1000.0
Cellular roles of Anthrax toxin	1.0	72.0	39.0	-0.071	0.016	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	141.0	85.0	-0.058	0.029	1000.0	-1000.0	-0.085	-1000.0
Arf6 downstream pathway	1.0	71.0	43.0	-0.082	0.045	1000.0	-1000.0	-0.05	-1000.0
IFN-gamma pathway	1.0	115.0	68.0	-0.094	0.036	1000.0	-1000.0	-0.105	-1000.0
Nectin adhesion pathway	1.0	120.0	63.0	-0.067	0.021	1000.0	-1000.0	-0.08	-1000.0
Ceramide signaling pathway	1.0	106.0	76.0	-0.133	0.029	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class III	1.0	69.0	40.0	-0.186	0.02	1000.0	-1000.0	-0.051	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.017	0.02	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	82.0	45.0	-0.092	0.02	1000.0	-1000.0	-0.099	-1000.0
Regulation of p38-alpha and p38-beta	1.0	81.0	54.0	-0.139	0.011	1000.0	-1000.0	-0.064	-1000.0
Nongenotropic Androgen signaling	1.0	87.0	52.0	-0.062	0.035	1000.0	-1000.0	-0.064	-1000.0
TCGA08_rtk_signaling	1.0	28.0	26.0	-0.04	0.035	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	1.0	112.0	75.0	-0.086	0.056	1000.0	-1000.0	-0.1	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	81.0	76.0	-0.083	0.05	1000.0	-1000.0	-0.097	-1000.0
IL2 signaling events mediated by STAT5	1.0	36.0	22.0	-0.065	0.02	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events	1.0	127.0	73.0	-0.139	0.011	1000.0	-1000.0	-0.077	-1000.0
Regulation of Telomerase	1.0	161.0	102.0	-0.138	0.039	1000.0	-1000.0	-0.104	-1000.0
Plasma membrane estrogen receptor signaling	1.0	154.0	86.0	-0.063	0.016	1000.0	-1000.0	-0.089	-1000.0
PDGFR-beta signaling pathway	1.0	98.0	97.0	-0.1	0.053	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by PRL	1.0	51.0	34.0	-0.166	0.028	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling in keratinocytes	1.0	43.0	43.0	-0.04	0.03	1000.0	-1000.0	-0.074	-1000.0
FOXM1 transcription factor network	1.0	55.0	51.0	-0.335	0.164	1000.0	-1000.0	-0.181	-1000.0
E-cadherin signaling events	1.0	5.0	5.0	-0.017	0.011	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	127.0	78.0	-0.191	0.031	1000.0	-1000.0	-0.08	-1000.0
Aurora B signaling	1.0	75.0	67.0	-0.132	0.031	1000.0	-1000.0	-0.074	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.041	1000.0	-1000.0	-0.073	-1000.0
Canonical NF-kappaB pathway	0.0	30.0	39.0	-0.071	0.063	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class II	0.0	36.0	75.0	-0.037	0.03	1000.0	-1000.0	-0.07	-1000.0
BARD1 signaling events	0.0	21.0	57.0	-0.01	0.054	1000.0	-1000.0	-0.068	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.011	0.02	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	0.0	38.0	60.0	-0.085	0.029	1000.0	-1000.0	-0.064	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.015	0.011	1000.0	-1000.0	-0.042	-1000.0
PLK1 signaling events	0.0	16.0	85.0	-0.01	0.022	1000.0	-1000.0	-0.051	-1000.0
Insulin-mediated glucose transport	0.0	14.0	32.0	-0.091	0.028	1000.0	-1000.0	-0.07	-1000.0
PDGFR-alpha signaling pathway	0.0	13.0	44.0	-0.03	0.028	1000.0	-1000.0	-0.06	-1000.0
mTOR signaling pathway	0.0	3.0	53.0	-0.019	0.022	1000.0	-1000.0	-0.066	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	39.0	68.0	-0.091	0.035	1000.0	-1000.0	-0.07	-1000.0
TRAIL signaling pathway	0.0	36.0	48.0	-0.035	0.043	1000.0	-1000.0	-0.07	-1000.0
ceramide signaling pathway	0.0	41.0	49.0	-0.082	0.021	1000.0	-1000.0	-0.057	-1000.0
HIF-2-alpha transcription factor network	0.0	34.0	43.0	-0.078	0.036	1000.0	-1000.0	-0.104	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	63.0	83.0	-0.139	0.054	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by HDAC Class I	0.0	55.0	104.0	-0.096	0.042	1000.0	-1000.0	-0.082	-1000.0
FoxO family signaling	0.0	26.0	64.0	-0.108	0.123	1000.0	-1000.0	-0.087	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	23.0	36.0	-0.025	0.02	1000.0	-1000.0	-0.073	-1000.0
Atypical NF-kappaB pathway	0.0	15.0	31.0	-0.025	0.026	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	104.0	125.0	-0.033	0.068	1000.0	-1000.0	-0.112	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.004	0.025	1000.0	-1000.0	-0.059	-1000.0
Arf6 trafficking events	0.0	34.0	71.0	-0.055	0.038	1000.0	-1000.0	-0.077	-1000.0
Insulin Pathway	0.0	57.0	74.0	-0.11	0.031	1000.0	-1000.0	-0.09	-1000.0
VEGFR1 specific signals	0.0	10.0	56.0	-0.013	0.047	1000.0	-1000.0	-0.091	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.018	0.011	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	0.0	32.0	44.0	-0.094	0.025	1000.0	-1000.0	-0.071	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.018	0.024	1000.0	-1000.0	-0.054	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.008	0.011	1000.0	-1000.0	-0.067	-1000.0
Ras signaling in the CD4+ TCR pathway	0.0	15.0	17.0	-0.017	0.03	1000.0	-1000.0	-0.055	-1000.0
Total	379	23335	7203	-20.1138103351	-1994.72165531	131000	-131000	-10.0869006104	-131000