Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.116 0.288 -9999.0 0.0 -0.558 20.0 20.0 IHH 0.015 0.105 0.198 9.0 -0.175 2.0 11.0 SHH Np/Cholesterol/GAS1 -0.066 0.15 -9999.0 0.0 -0.291 20.0 20.0 LRPAP1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.066 0.149 0.289 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.119 0.239 0.292 1.0 -0.515 13.0 14.0 SMO -0.138 0.238 0.309 1.0 -0.507 15.0 16.0 AKT1 -0.069 0.172 -9999.0 0.0 -0.615 4.0 4.0 ARRB2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.032 0.179 3.0 -9999.0 0.0 3.0 ADRBK1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.135 0.236 0.308 1.0 -0.499 15.0 16.0 STIL -0.114 0.16 0.215 2.0 -0.265 28.0 30.0 DHH N/PTCH2 0.01 0.103 -9999.0 0.0 -0.358 5.0 5.0 DHH N/PTCH1 -0.073 0.18 -9999.0 0.0 -0.294 27.0 27.0 PIK3CA 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.133 -9999.0 0.0 -0.491 5.0 5.0 PTHLH -0.234 0.465 -9999.0 0.0 -0.903 22.0 22.0 determination of left/right symmetry -0.135 0.236 0.308 1.0 -0.499 15.0 16.0 PIK3R1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.23 0.459 -9999.0 0.0 -0.891 22.0 22.0 IHH N/Hhip 0.017 0.155 0.261 1.0 -0.409 7.0 8.0 DHH N/Hhip -0.021 0.164 -9999.0 0.0 -0.385 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.135 0.236 0.308 1.0 -0.499 15.0 16.0 pancreas development -0.014 0.165 0.179 6.0 -0.491 7.0 13.0 HHAT 0.008 0.086 -9999.0 0.0 -0.491 2.0 2.0 PI3K 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.143 0.179 6.0 -0.491 5.0 11.0 somite specification -0.135 0.236 0.308 1.0 -0.499 15.0 16.0 SHH Np/Cholesterol/PTCH1 -0.117 0.161 -9999.0 0.0 -0.259 37.0 37.0 SHH Np/Cholesterol/PTCH2 -0.052 0.131 0.158 2.0 -0.281 16.0 18.0 SHH Np/Cholesterol/Megalin -0.075 0.172 0.158 2.0 -0.336 19.0 21.0 SHH -0.081 0.154 -9999.0 0.0 -0.36 16.0 16.0 catabolic process -0.064 0.188 -9999.0 0.0 -0.333 22.0 22.0 SMO/Vitamin D3 -0.141 0.21 0.308 2.0 -0.364 24.0 26.0 SHH Np/Cholesterol/Hhip -0.074 0.164 0.158 2.0 -0.308 21.0 23.0 LRP2 -0.02 0.16 0.179 3.0 -0.491 7.0 10.0 receptor-mediated endocytosis -0.171 0.214 -9999.0 0.0 -0.45 18.0 18.0 SHH Np/Cholesterol/BOC -0.052 0.13 0.158 1.0 -0.281 16.0 17.0 SHH Np/Cholesterol/CDO -0.053 0.126 -9999.0 0.0 -0.278 16.0 16.0 mesenchymal cell differentiation 0.073 0.163 0.306 21.0 -0.157 2.0 23.0 mol:Vitamin D3 -0.103 0.179 0.283 2.0 -0.272 29.0 31.0 IHH N/PTCH2 0.055 0.057 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.043 0.205 -9999.0 0.0 -0.335 22.0 22.0 Megalin/LRPAP1 0.002 0.119 -9999.0 0.0 -0.348 7.0 7.0 PTCH2 0.03 0.026 0.179 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol -0.061 0.119 -9999.0 0.0 -0.276 16.0 16.0 PTCH1 -0.064 0.189 -9999.0 0.0 -0.334 22.0 22.0 HHIP -0.014 0.165 0.179 6.0 -0.491 7.0 13.0