E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.161 -9999.0 0.0 -0.403 24.0 24.0 KLHL20 0.023 0.097 0.18 11.0 -0.237 3.0 14.0 CYFIP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.017 0.106 0.268 1.0 -0.261 19.0 20.0 ENAH -0.044 0.158 -9999.0 0.0 -0.402 23.0 23.0 AP1M1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.005 0.084 -9999.0 0.0 -0.192 20.0 20.0 ABI1/Sra1/Nap1 -0.02 0.043 -9999.0 0.0 -0.163 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.113 -9999.0 0.0 -0.226 24.0 24.0 RAPGEF1 -0.038 0.151 0.23 1.0 -0.379 21.0 22.0 CTNND1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.167 -9999.0 0.0 -0.41 24.0 24.0 CRK -0.042 0.155 -9999.0 0.0 -0.389 22.0 22.0 E-cadherin/gamma catenin/alpha catenin 0.007 0.114 -9999.0 0.0 -0.245 24.0 24.0 alphaE/beta7 Integrin 0.04 0.04 -9999.0 0.0 -0.275 2.0 2.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.052 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.048 0.16 -9999.0 0.0 -0.403 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.047 -9999.0 0.0 -0.148 20.0 20.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.056 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.043 0.06 -9999.0 0.0 -0.187 20.0 20.0 ARF6 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.013 0.123 -9999.0 0.0 -0.288 24.0 24.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.026 0.103 -9999.0 0.0 -0.21 23.0 23.0 AKT1 -0.018 0.051 -9999.0 0.0 -0.169 1.0 1.0 PIK3R1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.042 0.156 -9999.0 0.0 -0.4 23.0 23.0 RhoA/GDP -0.011 0.119 0.268 1.0 -0.26 21.0 22.0 actin cytoskeleton organization 0.021 0.076 0.145 12.0 -0.172 3.0 15.0 CDC42/GDP -0.012 0.118 0.268 1.0 -0.26 21.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.02 0.087 -9999.0 0.0 -0.214 24.0 24.0 ITGB7 0.025 0.051 -9999.0 0.0 -0.4 2.0 2.0 RAC1 0.021 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.028 0.111 -9999.0 0.0 -0.224 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.009 0.095 -9999.0 0.0 -0.205 23.0 23.0 mol:GDP -0.028 0.126 0.271 1.0 -0.295 21.0 22.0 CDC42/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.037 -9999.0 0.0 -0.4 1.0 1.0 p120 catenin/RhoA/GDP -0.002 0.125 0.272 1.0 -0.267 21.0 22.0 RAC1/GTP/IQGAP1 0.029 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.029 -9999.0 0.0 -0.286 1.0 1.0 RHOA 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.053 0.112 10.0 -0.12 2.0 12.0 NME1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.046 0.159 -9999.0 0.0 -0.409 23.0 23.0 regulation of cell-cell adhesion -0.014 0.067 -9999.0 0.0 -0.171 20.0 20.0 WASF2 0.006 0.039 0.083 1.0 -0.1 1.0 2.0 Rap1/GTP -0.005 0.094 0.169 1.0 -0.21 18.0 19.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.035 0.117 -9999.0 0.0 -0.216 25.0 25.0 CCND1 0.018 0.063 0.129 10.0 -0.146 2.0 12.0 VAV2 -0.046 0.209 -9999.0 0.0 -0.678 7.0 7.0 RAP1/GDP -0.003 0.103 -9999.0 0.0 -0.221 20.0 20.0 adherens junction assembly -0.044 0.155 -9999.0 0.0 -0.396 23.0 23.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.036 -9999.0 0.0 -0.4 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.012 0.106 -9999.0 0.0 -0.211 25.0 25.0 E-cadherin/beta catenin -0.044 0.114 -9999.0 0.0 -0.303 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.157 -9999.0 0.0 -0.401 23.0 23.0 PIK3CA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.033 0.098 -9999.0 0.0 -0.3 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.009 0.112 -9999.0 0.0 -0.243 23.0 23.0 ITGAE 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.041 0.17 -9999.0 0.0 -0.419 24.0 24.0