Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.011 0.098 0.299 13.0 -9999.0 0.0 13.0 KIRREL -0.005 0.126 -9999.0 0.0 -0.409 13.0 13.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.012 0.098 -9999.0 0.0 -0.299 13.0 13.0 PLCG1 0.026 0.037 -9999.0 0.0 -0.4 1.0 1.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.04 0.088 -9999.0 0.0 -0.226 13.0 13.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.061 -9999.0 0.0 -0.219 9.0 9.0 FYN -0.019 0.076 0.151 11.0 -0.215 13.0 24.0 mol:Ca2+ 0.034 0.092 -9999.0 0.0 -0.24 13.0 13.0 mol:DAG 0.036 0.093 -9999.0 0.0 -0.241 13.0 13.0 NPHS2 0.0 0.033 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.036 0.093 -9999.0 0.0 -0.241 13.0 13.0 regulation of endocytosis 0.027 0.077 -9999.0 0.0 -0.206 13.0 13.0 Nephrin/NEPH1/podocin/Cholesterol 0.026 0.081 -9999.0 0.0 -0.221 13.0 13.0 establishment of cell polarity 0.011 0.098 -9999.0 0.0 -0.299 13.0 13.0 Nephrin/NEPH1/podocin/NCK1-2 0.055 0.089 -9999.0 0.0 -0.21 13.0 13.0 Nephrin/NEPH1/beta Arrestin2 0.029 0.078 -9999.0 0.0 -0.208 13.0 13.0 NPHS1 0.001 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin 0.024 0.077 -9999.0 0.0 -0.216 13.0 13.0 TJP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.037 0.094 -9999.0 0.0 -0.242 13.0 13.0 CD2AP 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.044 0.086 -9999.0 0.0 -0.226 12.0 12.0 GRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.034 0.094 0.155 12.0 -0.221 22.0 34.0 cytoskeleton organization -0.018 0.062 0.195 1.0 -0.244 8.0 9.0 Nephrin/NEPH1 0.014 0.069 -9999.0 0.0 -0.204 13.0 13.0 Nephrin/NEPH1/ZO-1 0.029 0.086 -9999.0 0.0 -0.237 13.0 13.0