Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.005 0.127 -9999.0 0.0 -0.486 9.0 9.0 IHH 0.02 0.051 -9999.0 0.0 -0.168 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.012 0.075 -9999.0 0.0 -0.237 13.0 13.0 LRPAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.074 0.235 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.045 0.117 -9999.0 0.0 -0.524 3.0 3.0 SMO -0.005 0.092 -9999.0 0.0 -0.483 4.0 4.0 AKT1 -0.005 0.102 -9999.0 0.0 -0.376 8.0 8.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.037 -9999.0 0.0 -0.4 1.0 1.0 ADRBK1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.005 0.091 -9999.0 0.0 -0.476 4.0 4.0 STIL 0.015 0.121 0.18 21.0 -0.332 6.0 27.0 DHH N/PTCH2 0.021 0.078 -9999.0 0.0 -0.289 8.0 8.0 DHH N/PTCH1 0.007 0.107 -9999.0 0.0 -0.321 12.0 12.0 PIK3CA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.073 -9999.0 0.0 -0.4 4.0 4.0 PTHLH -0.015 0.155 -9999.0 0.0 -0.611 8.0 8.0 determination of left/right symmetry -0.005 0.091 -9999.0 0.0 -0.476 4.0 4.0 PIK3R1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.015 0.153 -9999.0 0.0 -0.605 8.0 8.0 IHH N/Hhip -0.016 0.124 -9999.0 0.0 -0.327 18.0 18.0 DHH N/Hhip -0.015 0.119 -9999.0 0.0 -0.299 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.005 0.091 -9999.0 0.0 -0.476 4.0 4.0 pancreas development -0.033 0.14 -9999.0 0.0 -0.4 18.0 18.0 HHAT 0.025 0.05 -9999.0 0.0 -0.4 2.0 2.0 PI3K 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.011 0.074 -9999.0 0.0 -0.4 4.0 4.0 somite specification -0.005 0.091 -9999.0 0.0 -0.476 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.019 0.091 -9999.0 0.0 -0.327 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.008 0.07 -9999.0 0.0 -0.237 11.0 11.0 SHH Np/Cholesterol/Megalin -0.038 0.102 -9999.0 0.0 -0.247 26.0 26.0 SHH -0.032 0.07 -9999.0 0.0 -0.286 10.0 10.0 catabolic process 0.001 0.1 -9999.0 0.0 -0.368 9.0 9.0 SMO/Vitamin D3 -0.016 0.104 -9999.0 0.0 -0.472 4.0 4.0 SHH Np/Cholesterol/Hhip -0.025 0.082 -9999.0 0.0 -0.225 20.0 20.0 LRP2 -0.073 0.175 -9999.0 0.0 -0.4 32.0 32.0 receptor-mediated endocytosis -0.043 0.128 -9999.0 0.0 -0.456 8.0 8.0 SHH Np/Cholesterol/BOC -0.005 0.062 -9999.0 0.0 -0.22 10.0 10.0 SHH Np/Cholesterol/CDO -0.006 0.064 -9999.0 0.0 -0.22 11.0 11.0 mesenchymal cell differentiation 0.025 0.082 0.224 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.029 0.131 0.196 30.0 -0.327 7.0 37.0 IHH N/PTCH2 0.028 0.069 -9999.0 0.0 -0.331 4.0 4.0 CDON 0.022 0.062 -9999.0 0.0 -0.4 3.0 3.0 IHH N/PTCH1 0.01 0.104 -9999.0 0.0 -0.37 9.0 9.0 Megalin/LRPAP1 -0.036 0.135 -9999.0 0.0 -0.286 32.0 32.0 PTCH2 0.019 0.071 -9999.0 0.0 -0.4 4.0 4.0 SHH Np/Cholesterol -0.01 0.057 -9999.0 0.0 -0.215 10.0 10.0 PTCH1 0.001 0.1 -9999.0 0.0 -0.369 9.0 9.0 HHIP -0.033 0.141 -9999.0 0.0 -0.4 18.0 18.0