Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.086 -9999.0 0.0 -0.206 24.0 24.0 epithelial cell differentiation 0.021 0.1 -9999.0 0.0 -0.208 23.0 23.0 CYFIP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.042 0.068 0.418 1.0 -9999.0 0.0 1.0 EGFR -0.071 0.16 -9999.0 0.0 -0.4 28.0 28.0 EPHA2 0.026 0.038 -9999.0 0.0 -0.4 1.0 1.0 MYO6 -0.045 0.072 0.168 3.0 -0.204 22.0 25.0 CTNNB1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.031 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.105 0.189 -9999.0 0.0 -0.46 29.0 29.0 CTNND1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.071 0.166 3.0 -0.201 21.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.05 0.083 0.166 3.0 -0.215 26.0 29.0 EGF 0.003 0.104 -9999.0 0.0 -0.4 9.0 9.0 NCKAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.094 -9999.0 0.0 -0.354 6.0 6.0 cortical microtubule organization 0.021 0.1 -9999.0 0.0 -0.208 23.0 23.0 GO:0000145 -0.043 0.067 0.151 3.0 -0.191 22.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.103 -9999.0 0.0 -0.21 23.0 23.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.056 0.058 -9999.0 0.0 -0.195 21.0 21.0 ARF6 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.07 0.042 -9999.0 0.0 -0.225 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.03 0.064 0.167 1.0 -9999.0 0.0 1.0 PVRL2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.069 0.174 2.0 -0.203 19.0 21.0 ARF6/GTP 0.074 0.046 -9999.0 0.0 -0.205 2.0 2.0 CDH1 -0.042 0.156 -9999.0 0.0 -0.4 23.0 23.0 EGFR/EGFR/EGF/EGF -0.055 0.115 -9999.0 0.0 -0.243 36.0 36.0 RhoA/GDP 0.023 0.099 -9999.0 0.0 -0.202 23.0 23.0 actin cytoskeleton organization -0.041 0.072 0.148 2.0 -0.205 22.0 24.0 IGF-1R heterotetramer 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.01 0.087 -9999.0 0.0 -0.4 6.0 6.0 DIAPH1 -0.091 0.241 -9999.0 0.0 -0.562 3.0 3.0 Wnt receptor signaling pathway -0.021 0.1 0.208 23.0 -9999.0 0.0 23.0 RHOA 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.057 0.058 -9999.0 0.0 -0.197 21.0 21.0 CTNNA1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.042 0.074 0.149 2.0 -0.209 22.0 24.0 EFNA1 0.028 0.036 -9999.0 0.0 -0.4 1.0 1.0 LPP -0.048 0.069 0.153 2.0 -0.199 22.0 24.0 Ephrin A1/EPHA2 0.014 0.093 -9999.0 0.0 -0.202 21.0 21.0 SEC6/SEC8 -0.042 0.061 -9999.0 0.0 -0.199 17.0 17.0 MGAT3 -0.051 0.084 0.168 3.0 -0.218 26.0 29.0 HGF/MET -0.037 0.12 -9999.0 0.0 -0.241 33.0 33.0 HGF -0.009 0.102 -9999.0 0.0 -0.4 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.087 -9999.0 0.0 -0.208 24.0 24.0 actin cable formation -0.024 0.07 0.373 1.0 -9999.0 0.0 1.0 KIAA1543 -0.05 0.074 0.149 2.0 -0.203 25.0 27.0 KIFC3 -0.049 0.068 0.154 1.0 -0.203 23.0 24.0 NCK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.046 0.071 0.164 2.0 -0.203 23.0 25.0 NCK1/GIT1 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.1 -9999.0 0.0 -0.208 23.0 23.0 EXOC4 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.071 0.164 2.0 -0.203 23.0 25.0 PIP5K1C -0.045 0.072 0.168 3.0 -0.203 22.0 25.0 LIMA1 0.028 0.036 -9999.0 0.0 -0.4 1.0 1.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.045 0.075 0.445 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.041 0.084 0.245 1.0 -0.305 4.0 5.0 IGF-1R heterotetramer/IGF1 0.006 0.106 -9999.0 0.0 -0.211 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.029 0.124 -9999.0 0.0 -0.4 14.0 14.0 PLEKHA7 -0.052 0.077 0.164 2.0 -0.212 25.0 27.0 mol:GTP 0.068 0.042 -9999.0 0.0 -0.224 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.011 0.125 0.311 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization -0.015 0.086 -9999.0 0.0 -0.206 24.0 24.0 regulation of cell-cell adhesion -0.041 0.072 0.148 2.0 -0.205 22.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.087 -9999.0 0.0 -0.208 24.0 24.0