Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	20.0	1207.0	60.0	-0.407	0.032	1000.0	-1000.0	-0.091	-1000.0
Syndecan-1-mediated signaling events	18.0	644.0	34.0	-0.106	0.032	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1454.0	93.0	-0.293	0.331	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1363.0	88.0	-0.179	0.032	1000.0	-1000.0	-0.049	-1000.0
Endothelins	14.0	1351.0	96.0	-0.152	0.066	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-alpha and p38-beta	14.0	652.0	44.0	-0.086	0.04	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.042	0.032	1000.0	-1000.0	0.017	-1000.0
Ephrin A  reverse signaling	13.0	96.0	7.0	-0.042	0.003	1000.0	-1000.0	-0.019	-1000.0
Ceramide signaling pathway	13.0	1058.0	76.0	-0.125	0.047	1000.0	-1000.0	-0.028	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	962.0	74.0	-0.105	0.074	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	13.0	276.0	21.0	-0.071	0.047	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	13.0	880.0	67.0	-0.12	0.032	1000.0	-1000.0	-0.041	-1000.0
HIF-1-alpha transcription factor network	12.0	932.0	76.0	-0.139	0.045	1000.0	-1000.0	-0.069	-1000.0
Arf6 signaling events	12.0	770.0	62.0	-0.071	0.07	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	12.0	1127.0	91.0	-0.451	0.315	1000.0	-1000.0	-0.103	-1000.0
Reelin signaling pathway	12.0	686.0	56.0	-0.066	0.061	1000.0	-1000.0	-0.038	-1000.0
IL12-mediated signaling events	11.0	978.0	87.0	-0.274	0.043	1000.0	-1000.0	-0.07	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	515.0	46.0	-0.244	0.032	1000.0	-1000.0	-0.095	-1000.0
EPO signaling pathway	11.0	627.0	55.0	-0.01	0.078	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	10.0	687.0	65.0	-0.087	0.046	1000.0	-1000.0	-0.046	-1000.0
Caspase cascade in apoptosis	10.0	777.0	74.0	-0.14	0.046	1000.0	-1000.0	-0.038	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	869.0	82.0	-0.103	0.032	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	823.0	76.0	-0.048	0.056	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Cones	9.0	345.0	38.0	-0.068	0.035	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by the Hedgehog family	9.0	494.0	52.0	-0.073	0.045	1000.0	-1000.0	-0.035	-1000.0
Thromboxane A2 receptor signaling	9.0	973.0	105.0	-0.076	0.044	1000.0	-1000.0	-0.041	-1000.0
PDGFR-alpha signaling pathway	9.0	400.0	44.0	-0.052	0.04	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	9.0	1066.0	114.0	-0.271	0.173	1000.0	-1000.0	-0.05	-1000.0
HIF-2-alpha transcription factor network	9.0	425.0	43.0	-0.092	0.06	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	9.0	253.0	26.0	-0.049	0.031	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling in keratinocytes	9.0	396.0	43.0	-0.071	0.037	1000.0	-1000.0	-0.029	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	297.0	34.0	-0.034	0.055	1000.0	-1000.0	-0.025	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	762.0	85.0	-0.059	0.088	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	8.0	1085.0	125.0	-0.07	0.08	1000.0	-1000.0	-0.066	-1000.0
Glypican 1 network	8.0	425.0	48.0	-0.085	0.061	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	435.0	52.0	-0.076	0.08	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	8.0	220.0	26.0	-0.071	0.093	1000.0	-1000.0	-0.006	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	558.0	68.0	-0.198	0.039	1000.0	-1000.0	-0.075	-1000.0
TCGA08_retinoblastoma	8.0	71.0	8.0	-0.018	0.076	1000.0	-1000.0	-0.003	-1000.0
Osteopontin-mediated events	7.0	273.0	38.0	-0.08	0.035	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	420.0	54.0	-0.046	0.046	1000.0	-1000.0	-0.037	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	135.0	17.0	-0.137	0.044	1000.0	-1000.0	-0.036	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	706.0	97.0	-0.133	0.052	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	7.0	599.0	82.0	-0.117	0.043	1000.0	-1000.0	-0.028	-1000.0
Nectin adhesion pathway	7.0	450.0	63.0	-0.042	0.057	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	7.0	348.0	47.0	-0.175	0.048	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	7.0	436.0	58.0	-0.08	0.058	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	7.0	646.0	85.0	-0.052	0.079	1000.0	-1000.0	-0.053	-1000.0
Nongenotropic Androgen signaling	7.0	369.0	52.0	-0.043	0.04	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	903.0	125.0	-0.038	0.059	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	7.0	50.0	7.0	-0.018	0.026	1000.0	-1000.0	-0.02	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	233.0	33.0	-0.059	0.06	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Rods	7.0	384.0	52.0	-0.068	0.032	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	6.0	429.0	62.0	-0.046	0.059	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by PI3K	6.0	370.0	58.0	-0.225	0.046	1000.0	-1000.0	-0.04	-1000.0
Integrins in angiogenesis	6.0	510.0	84.0	-0.053	0.077	1000.0	-1000.0	-0.032	-1000.0
Glypican 2 network	6.0	27.0	4.0	0.001	0.008	1000.0	-1000.0	0.02	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	545.0	78.0	-0.039	0.058	1000.0	-1000.0	-0.056	-1000.0
Noncanonical Wnt signaling pathway	5.0	145.0	26.0	-0.051	0.032	1000.0	-1000.0	-0.039	-1000.0
BMP receptor signaling	5.0	429.0	81.0	-0.049	0.06	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	5.0	252.0	48.0	-0.026	0.052	1000.0	-1000.0	-0.026	-1000.0
S1P1 pathway	5.0	199.0	36.0	-0.045	0.032	1000.0	-1000.0	-0.041	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	170.0	31.0	-0.078	0.03	1000.0	-1000.0	-0.039	-1000.0
LPA receptor mediated events	5.0	556.0	102.0	-0.158	0.059	1000.0	-1000.0	-0.055	-1000.0
S1P4 pathway	5.0	130.0	25.0	-0.0	0.054	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	4.0	48.0	12.0	-0.033	0.0	1000.0	-1000.0	-0.022	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	631.0	136.0	-0.24	0.123	1000.0	-1000.0	-0.034	-1000.0
Syndecan-2-mediated signaling events	4.0	335.0	69.0	-0.057	0.052	1000.0	-1000.0	-0.033	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	22.0	5.0	0.011	0.025	1000.0	-1000.0	0.015	-1000.0
Signaling events mediated by PTP1B	4.0	351.0	76.0	-0.09	0.047	1000.0	-1000.0	-0.028	-1000.0
mTOR signaling pathway	4.0	248.0	53.0	-0.018	0.072	1000.0	-1000.0	-0.032	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	180.0	37.0	-0.035	0.045	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	4.0	73.0	17.0	-0.026	0.032	1000.0	-1000.0	-0.008	-1000.0
ceramide signaling pathway	4.0	215.0	49.0	-0.026	0.045	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	187.0	45.0	-0.074	0.059	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	4.0	216.0	51.0	-0.07	0.103	1000.0	-1000.0	-0.034	-1000.0
IL6-mediated signaling events	4.0	341.0	75.0	-0.056	0.071	1000.0	-1000.0	-0.057	-1000.0
IL2 signaling events mediated by STAT5	4.0	105.0	22.0	-0.082	0.033	1000.0	-1000.0	-0.044	-1000.0
BCR signaling pathway	4.0	469.0	99.0	-0.053	0.068	1000.0	-1000.0	-0.055	-1000.0
IGF1 pathway	4.0	233.0	57.0	-0.046	0.075	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	4.0	414.0	86.0	-0.034	0.055	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	4.0	259.0	56.0	-0.029	0.057	1000.0	-1000.0	-0.038	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	593.0	120.0	-0.067	0.086	1000.0	-1000.0	-0.045	-1000.0
FOXM1 transcription factor network	4.0	254.0	51.0	-0.057	0.059	1000.0	-1000.0	-0.13	-1000.0
Aurora B signaling	4.0	307.0	67.0	-0.103	0.063	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	3.0	289.0	76.0	-0.082	0.058	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	3.0	121.0	39.0	-0.041	0.042	1000.0	-1000.0	-0.017	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	191.0	61.0	-0.069	0.081	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	3.0	142.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	3.0	25.0	7.0	0.0	0.032	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	3.0	331.0	85.0	-0.022	0.049	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	262.0	68.0	-0.027	0.06	1000.0	-1000.0	-0.025	-1000.0
TRAIL signaling pathway	3.0	167.0	48.0	-0.042	0.08	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	3.0	27.0	7.0	-0.014	0.03	1000.0	-1000.0	-0.012	-1000.0
FoxO family signaling	3.0	212.0	64.0	-0.069	0.072	1000.0	-1000.0	-0.054	-1000.0
Atypical NF-kappaB pathway	3.0	105.0	31.0	-0.014	0.044	1000.0	-1000.0	-0.027	-1000.0
Syndecan-3-mediated signaling events	3.0	116.0	35.0	-0.071	0.08	1000.0	-1000.0	-0.015	-1000.0
IL27-mediated signaling events	3.0	160.0	51.0	-0.073	0.047	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events	3.0	270.0	73.0	-0.035	0.09	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	3.0	249.0	74.0	-0.062	0.079	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	3.0	326.0	97.0	-0.024	0.084	1000.0	-1000.0	-0.05	-1000.0
Regulation of Androgen receptor activity	3.0	224.0	70.0	-0.111	0.042	1000.0	-1000.0	-0.049	-1000.0
ErbB4 signaling events	2.0	193.0	69.0	-0.071	0.046	1000.0	-1000.0	-0.039	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	56.0	28.0	-0.018	0.043	1000.0	-1000.0	-0.028	-1000.0
Insulin-mediated glucose transport	2.0	92.0	32.0	-0.024	0.063	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	2.0	175.0	68.0	-0.054	0.066	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by HDAC Class III	2.0	86.0	40.0	-0.046	0.046	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	233.0	83.0	-0.055	0.061	1000.0	-1000.0	-0.027	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	99.0	36.0	-0.032	0.045	1000.0	-1000.0	-0.028	-1000.0
Regulation of p38-alpha and p38-beta	2.0	139.0	54.0	-0.062	0.052	1000.0	-1000.0	-0.044	-1000.0
Arf6 trafficking events	2.0	150.0	71.0	-0.055	0.057	1000.0	-1000.0	-0.028	-1000.0
Regulation of Telomerase	2.0	289.0	102.0	-0.102	0.083	1000.0	-1000.0	-0.046	-1000.0
S1P3 pathway	2.0	115.0	42.0	-0.017	0.042	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.025	0.025	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.0	0.054	1000.0	-1000.0	-0.024	-1000.0
Canonical NF-kappaB pathway	1.0	47.0	39.0	-0.013	0.07	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	1.0	65.0	57.0	-0.069	0.081	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.019	0.029	1000.0	-1000.0	-0.026	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	112.0	65.0	-0.005	0.071	1000.0	-1000.0	-0.045	-1000.0
Aurora A signaling	1.0	74.0	60.0	-0.022	0.069	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	1.0	153.0	104.0	-0.06	0.073	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	23.0	15.0	-0.023	0.032	1000.0	-1000.0	-0.029	-1000.0
Rapid glucocorticoid signaling	1.0	26.0	20.0	-0.017	0.038	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PRL	1.0	35.0	34.0	-0.029	0.046	1000.0	-1000.0	-0.042	-1000.0
p38 MAPK signaling pathway	1.0	83.0	44.0	-0.017	0.046	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	1.0	55.0	54.0	-0.07	0.055	1000.0	-1000.0	-0.018	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	-0.014	0.057	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	0.0	34.0	75.0	-0.036	0.087	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.007	0.061	1000.0	-1000.0	-0.032	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.017	0.07	1000.0	-1000.0	-0.033	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.065	1000.0	-1000.0	-0.0	-1000.0
Total	763	47829	7203	-9.53924035096	7.69563927874	131000	-131000	-4.62148277234	-131000