E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.049 -9999.0 0.0 -0.294 12.0 12.0 KLHL20 0.027 0.07 0.173 31.0 -0.185 17.0 48.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.005 0.041 0.165 12.0 -0.161 8.0 20.0 ENAH 0.006 0.052 -9999.0 0.0 -0.294 13.0 13.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.113 19.0 -0.115 7.0 26.0 ABI1/Sra1/Nap1 -0.011 0.024 -9999.0 0.0 -0.123 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.033 -9999.0 0.0 -0.053 11.0 11.0 RAPGEF1 -0.001 0.059 0.163 33.0 -0.274 10.0 43.0 CTNND1 0.03 0.014 -9999.0 0.0 -0.065 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.055 -9999.0 0.0 -0.295 13.0 13.0 CRK 0.005 0.06 0.172 25.0 -0.285 12.0 37.0 E-cadherin/gamma catenin/alpha catenin 0.058 0.026 -9999.0 0.0 -0.055 20.0 20.0 alphaE/beta7 Integrin 0.046 0.011 -9999.0 0.0 -0.051 2.0 2.0 IQGAP1 0.009 0.041 -9999.0 0.0 -0.065 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.035 0.018 -9999.0 0.0 -0.023 43.0 43.0 DLG1 0.006 0.052 -9999.0 0.0 -0.293 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.018 -9999.0 0.0 -0.084 17.0 17.0 MLLT4 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.017 -9999.0 0.0 -0.023 27.0 27.0 PI3K -0.036 0.022 -9999.0 0.0 -0.112 11.0 11.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.042 0.022 -9999.0 0.0 -0.058 19.0 19.0 TIAM1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.066 0.033 -9999.0 0.0 -0.048 18.0 18.0 AKT1 -0.016 0.036 0.148 7.0 -0.098 1.0 8.0 PIK3R1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.065 8.0 8.0 RhoA/GDP 0.011 0.06 0.172 28.0 -0.164 15.0 43.0 actin cytoskeleton organization 0.023 0.055 0.143 31.0 -0.137 17.0 48.0 CDC42/GDP 0.011 0.058 0.172 23.0 -0.163 15.0 38.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -9999.0 0.0 -0.102 20.0 20.0 ITGB7 0.031 0.007 -9999.0 0.0 -0.065 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.071 0.036 -9999.0 0.0 -0.051 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.021 -9999.0 0.0 -0.032 27.0 27.0 mol:GDP -0.002 0.062 0.171 28.0 -0.178 15.0 43.0 CDC42/GTP/IQGAP1 0.022 0.036 -9999.0 0.0 -0.041 119.0 119.0 JUP 0.029 0.017 -9999.0 0.0 -0.065 16.0 16.0 p120 catenin/RhoA/GDP 0.024 0.064 0.18 33.0 -0.168 16.0 49.0 RAC1/GTP/IQGAP1 0.015 0.032 -9999.0 0.0 -0.041 90.0 90.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.04 0.108 27.0 -0.095 16.0 43.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.007 0.051 -9999.0 0.0 -0.294 13.0 13.0 regulation of cell-cell adhesion -0.029 0.017 0.043 2.0 -0.098 11.0 13.0 WASF2 -0.006 0.013 -9999.0 0.0 -0.065 18.0 18.0 Rap1/GTP -0.022 0.044 0.141 30.0 -0.133 3.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.082 0.043 -9999.0 0.0 -0.077 5.0 5.0 CCND1 0.016 0.047 0.126 26.0 -0.114 16.0 42.0 VAV2 0.01 0.12 -9999.0 0.0 -0.548 17.0 17.0 RAP1/GDP -0.011 0.051 0.16 32.0 -0.178 1.0 33.0 adherens junction assembly 0.006 0.052 -9999.0 0.0 -0.286 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.188 3.0 -0.08 5.0 8.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.153 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 1.0 1.0 SRC 0.006 0.05 -9999.0 0.0 -0.294 12.0 12.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.065 17.0 17.0 Rac1/GTP -0.009 0.06 -9999.0 0.0 -0.278 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.06 0.021 -9999.0 0.0 -0.05 9.0 9.0 ITGAE 0.031 0.005 -9999.0 0.0 0.0 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.056 -9999.0 0.0 -0.301 13.0 13.0