Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.018 0.055 1.0 -0.116 4.0 5.0 KIRREL 0.035 0.011 0.083 1.0 -0.038 5.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.018 0.116 4.0 -0.055 1.0 5.0 PLCG1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.068 0.045 0.179 7.0 -9999.0 0.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.019 -9999.0 0.0 -0.118 4.0 4.0 FYN -0.01 0.044 0.163 28.0 -9999.0 0.0 28.0 mol:Ca2+ 0.073 0.036 0.171 19.0 -9999.0 0.0 19.0 mol:DAG 0.075 0.037 0.174 19.0 -9999.0 0.0 19.0 NPHS2 0.035 0.01 0.083 1.0 -0.03 4.0 5.0 mol:IP3 0.075 0.037 0.174 19.0 -9999.0 0.0 19.0 regulation of endocytosis 0.055 0.029 0.134 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.061 0.029 0.156 19.0 -9999.0 0.0 19.0 establishment of cell polarity 0.049 0.018 0.116 4.0 -0.055 1.0 5.0 Nephrin/NEPH1/podocin/NCK1-2 0.089 0.039 0.188 10.0 -9999.0 0.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.057 0.03 0.139 1.0 -9999.0 0.0 1.0 NPHS1 0.034 0.011 0.093 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1/podocin 0.058 0.024 0.166 4.0 -0.057 2.0 6.0 TJP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.015 -9999.0 0.0 -0.065 11.0 11.0 NCK2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.076 0.038 0.178 19.0 -9999.0 0.0 19.0 CD2AP 0.022 0.029 -9999.0 0.0 -0.065 48.0 48.0 Nephrin/NEPH1/podocin/GRB2 0.078 0.035 0.179 16.0 -9999.0 0.0 16.0 GRB2 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.013 0.05 0.172 30.0 -9999.0 0.0 30.0 cytoskeleton organization -0.008 0.032 0.171 11.0 -0.147 3.0 14.0 Nephrin/NEPH1 0.041 0.016 0.097 4.0 -0.029 5.0 9.0 Nephrin/NEPH1/ZO-1 0.062 0.024 -9999.0 0.0 -0.05 1.0 1.0