Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.023 0.03 -9999.0 0.0 -0.131 23.0 23.0 epithelial cell differentiation 0.06 0.031 -9999.0 0.0 -0.047 18.0 18.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.045 0.052 0.407 4.0 -9999.0 0.0 4.0 EGFR 0.012 0.017 -9999.0 0.0 -0.065 5.0 5.0 EPHA2 0.029 0.016 -9999.0 0.0 -0.065 12.0 12.0 MYO6 -0.03 0.029 0.164 10.0 -9999.0 0.0 10.0 CTNNB1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.029 0.032 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.013 0.043 -9999.0 0.0 -0.314 7.0 7.0 CTNND1 0.03 0.014 -9999.0 0.0 -0.065 10.0 10.0 mol:PI-4-5-P2 -0.03 0.023 0.16 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.029 0.163 10.0 -9999.0 0.0 10.0 EGF 0.031 0.007 -9999.0 0.0 -0.065 2.0 2.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.03 0.078 -9999.0 0.0 -0.316 32.0 32.0 cortical microtubule organization 0.06 0.031 -9999.0 0.0 -0.047 18.0 18.0 GO:0000145 -0.028 0.021 0.146 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.066 0.033 -9999.0 0.0 -0.047 18.0 18.0 MLLT4 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.053 0.016 -9999.0 0.0 -0.101 2.0 2.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.066 0.042 -9999.0 0.0 -0.056 33.0 33.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.023 0.158 2.0 -0.191 1.0 3.0 PVRL2 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.027 0.16 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.069 0.05 -9999.0 0.0 -0.075 7.0 7.0 CDH1 0.03 0.013 -9999.0 0.0 -0.065 8.0 8.0 EGFR/EGFR/EGF/EGF 0.019 0.034 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.061 0.033 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.024 0.026 0.144 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.031 0.009 -9999.0 0.0 -0.065 4.0 4.0 DIAPH1 -0.214 0.258 -9999.0 0.0 -0.452 267.0 267.0 Wnt receptor signaling pathway -0.06 0.031 0.047 18.0 -9999.0 0.0 18.0 RHOA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.016 -9999.0 0.0 -0.101 2.0 2.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.024 0.027 0.145 8.0 -9999.0 0.0 8.0 EFNA1 0.027 0.02 -9999.0 0.0 -0.065 21.0 21.0 LPP -0.035 0.023 0.15 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 0.046 0.041 -9999.0 0.0 -0.073 8.0 8.0 SEC6/SEC8 -0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.029 0.029 0.164 10.0 -9999.0 0.0 10.0 HGF/MET 0.035 0.037 -9999.0 0.0 -0.073 1.0 1.0 HGF 0.022 0.015 -9999.0 0.0 -0.065 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.023 0.03 -9999.0 0.0 -0.132 23.0 23.0 actin cable formation -0.038 0.075 0.339 10.0 -0.215 10.0 20.0 KIAA1543 -0.024 0.022 0.149 8.0 -9999.0 0.0 8.0 KIFC3 -0.031 0.024 0.165 7.0 -9999.0 0.0 7.0 NCK1 0.029 0.015 -9999.0 0.0 -0.065 11.0 11.0 EXOC3 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.027 0.165 8.0 -9999.0 0.0 8.0 NCK1/GIT1 0.044 0.017 -9999.0 0.0 -0.051 11.0 11.0 mol:GDP 0.06 0.031 -9999.0 0.0 -0.047 18.0 18.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.031 0.027 0.164 9.0 -9999.0 0.0 9.0 PIP5K1C -0.03 0.023 0.162 6.0 -9999.0 0.0 6.0 LIMA1 -0.05 0.035 -9999.0 0.0 -0.065 425.0 425.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.041 0.066 0.41 7.0 -9999.0 0.0 7.0 adherens junction assembly -0.023 0.042 0.213 5.0 -0.202 9.0 14.0 IGF-1R heterotetramer/IGF1 0.052 0.034 -9999.0 0.0 -0.073 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.016 -9999.0 0.0 -0.065 2.0 2.0 PLEKHA7 -0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.064 0.041 -9999.0 0.0 -0.056 33.0 33.0 establishment of epithelial cell apical/basal polarity -0.04 0.042 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.023 0.03 -9999.0 0.0 -0.131 23.0 23.0 regulation of cell-cell adhesion -0.024 0.026 0.144 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.023 0.03 -9999.0 0.0 -0.132 23.0 23.0