Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.001 0.106 0.315 47.0 -9999.0 0.0 47.0 KIRREL 0.002 0.099 -9999.0 0.0 -0.448 22.0 22.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.001 0.106 -9999.0 0.0 -0.315 47.0 47.0 PLCG1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.024 0.097 -9999.0 0.0 -0.291 25.0 25.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.002 0.061 -9999.0 0.0 -0.253 19.0 19.0 FYN -0.016 0.085 0.271 9.0 -0.274 24.0 33.0 mol:Ca2+ 0.023 0.094 -9999.0 0.0 -0.24 50.0 50.0 mol:DAG 0.024 0.095 -9999.0 0.0 -0.241 50.0 50.0 NPHS2 -0.013 0.068 -9999.0 0.0 -0.406 12.0 12.0 mol:IP3 0.024 0.095 -9999.0 0.0 -0.241 50.0 50.0 regulation of endocytosis 0.021 0.084 -9999.0 0.0 -0.262 23.0 23.0 Nephrin/NEPH1/podocin/Cholesterol 0.011 0.092 -9999.0 0.0 -0.243 52.0 52.0 establishment of cell polarity 0.001 0.106 -9999.0 0.0 -0.315 47.0 47.0 Nephrin/NEPH1/podocin/NCK1-2 0.033 0.09 -9999.0 0.0 -0.283 18.0 18.0 Nephrin/NEPH1/beta Arrestin2 0.023 0.085 -9999.0 0.0 -0.264 23.0 23.0 NPHS1 -0.02 0.1 -9999.0 0.0 -0.404 29.0 29.0 Nephrin/NEPH1/podocin 0.015 0.085 -9999.0 0.0 -0.228 46.0 46.0 TJP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.025 0.096 -9999.0 0.0 -0.242 50.0 50.0 CD2AP 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.025 0.098 -9999.0 0.0 -0.293 25.0 25.0 GRB2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.03 0.096 0.28 7.0 -0.25 51.0 58.0 cytoskeleton organization -0.01 0.071 0.231 3.0 -0.293 18.0 21.0 Nephrin/NEPH1 0.006 0.075 -9999.0 0.0 -0.217 47.0 47.0 Nephrin/NEPH1/ZO-1 0.019 0.091 -9999.0 0.0 -0.251 46.0 46.0