Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.154 0.139 -9999.0 0.0 -0.543 14.0 14.0 IHH -0.039 0.059 -9999.0 0.0 -0.331 4.0 4.0 SHH Np/Cholesterol/GAS1 0.003 0.068 -9999.0 0.0 -0.213 44.0 44.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.003 0.068 0.212 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.084 0.119 -9999.0 0.0 -0.45 23.0 23.0 SMO -0.09 0.121 -9999.0 0.0 -0.472 24.0 24.0 AKT1 -0.039 0.108 -9999.0 0.0 -0.5 16.0 16.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.016 0.132 -9999.0 0.0 -0.448 42.0 42.0 ADRBK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.088 0.12 -9999.0 0.0 -0.465 24.0 24.0 STIL -0.086 0.097 -9999.0 0.0 -0.388 14.0 14.0 DHH N/PTCH2 0.031 0.055 -9999.0 0.0 -0.299 13.0 13.0 DHH N/PTCH1 -0.084 0.098 -9999.0 0.0 -0.503 7.0 7.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.021 0.03 -9999.0 0.0 -0.393 2.0 2.0 PTHLH -0.215 0.176 -9999.0 0.0 -0.592 25.0 25.0 determination of left/right symmetry -0.088 0.12 -9999.0 0.0 -0.465 24.0 24.0 PIK3R1 0.024 0.038 -9999.0 0.0 -0.449 3.0 3.0 skeletal system development -0.214 0.175 -9999.0 0.0 -0.587 25.0 25.0 IHH N/Hhip -0.033 0.085 -9999.0 0.0 -0.319 32.0 32.0 DHH N/Hhip 0.018 0.078 -9999.0 0.0 -0.282 31.0 31.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.088 0.12 -9999.0 0.0 -0.465 24.0 24.0 pancreas development -0.006 0.1 -9999.0 0.0 -0.398 29.0 29.0 HHAT 0.026 0.031 -9999.0 0.0 -0.449 2.0 2.0 PI3K 0.027 0.03 -9999.0 0.0 -0.321 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.022 0.048 -9999.0 0.0 -0.412 6.0 6.0 somite specification -0.088 0.12 -9999.0 0.0 -0.465 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.091 0.097 -9999.0 0.0 -0.341 32.0 32.0 SHH Np/Cholesterol/PTCH2 0.0 0.076 -9999.0 0.0 -0.228 47.0 47.0 SHH Np/Cholesterol/Megalin -0.009 0.085 -9999.0 0.0 -0.236 55.0 55.0 SHH -0.021 0.077 -9999.0 0.0 -0.281 39.0 39.0 catabolic process -0.099 0.103 -9999.0 0.0 -0.432 13.0 13.0 SMO/Vitamin D3 -0.086 0.11 -9999.0 0.0 -0.438 15.0 15.0 SHH Np/Cholesterol/Hhip -0.012 0.088 -9999.0 0.0 -0.238 60.0 60.0 LRP2 -0.003 0.094 -9999.0 0.0 -0.394 26.0 26.0 receptor-mediated endocytosis -0.089 0.112 -9999.0 0.0 -0.452 18.0 18.0 SHH Np/Cholesterol/BOC -0.016 0.091 -9999.0 0.0 -0.234 72.0 72.0 SHH Np/Cholesterol/CDO -0.001 0.074 -9999.0 0.0 -0.222 48.0 48.0 mesenchymal cell differentiation 0.012 0.088 0.236 60.0 -9999.0 0.0 60.0 mol:Vitamin D3 -0.087 0.104 0.371 1.0 -0.341 32.0 33.0 IHH N/PTCH2 -0.02 0.066 -9999.0 0.0 -0.327 14.0 14.0 CDON 0.016 0.067 -9999.0 0.0 -0.449 10.0 10.0 IHH N/PTCH1 -0.097 0.107 -9999.0 0.0 -0.434 13.0 13.0 Megalin/LRPAP1 0.021 0.07 -9999.0 0.0 -0.273 26.0 26.0 PTCH2 0.017 0.067 -9999.0 0.0 -0.425 11.0 11.0 SHH Np/Cholesterol -0.002 0.061 -9999.0 0.0 -0.211 39.0 39.0 PTCH1 -0.099 0.103 -9999.0 0.0 -0.433 13.0 13.0 HHIP -0.006 0.1 -9999.0 0.0 -0.399 29.0 29.0