This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.
Testing the association between mutation status of 4 genes and 8 molecular subtypes across 66 patients, no significant finding detected with P value < 0.05 and Q value < 0.25.
-
No gene mutations related to molecuar subtypes.
Clinical Features |
CN CNMF |
METHLYATION CNMF |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nMutated (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
TP53 | 22 (33%) | 44 |
0.615 (1.00) |
0.0883 (1.00) |
0.0641 (1.00) |
0.0155 (0.479) |
0.642 (1.00) |
0.66 (1.00) |
0.779 (1.00) |
0.238 (1.00) |
PTEN | 6 (9%) | 60 |
0.0982 (1.00) |
0.322 (1.00) |
0.348 (1.00) |
0.477 (1.00) |
0.352 (1.00) |
0.0684 (1.00) |
0.0112 (0.358) |
0.17 (1.00) |
PABPC1 | 7 (11%) | 59 |
0.491 (1.00) |
0.237 (1.00) |
0.206 (1.00) |
0.743 (1.00) |
0.611 (1.00) |
0.309 (1.00) |
0.691 (1.00) |
0.0442 (1.00) |
URGCP | 3 (5%) | 63 |
0.643 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.193 (1.00) |
0.541 (1.00) |
0.809 (1.00) |
0.411 (1.00) |
P value = 0.615 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 47 | 14 |
TP53 MUTATED | 2 | 14 | 6 |
TP53 WILD-TYPE | 3 | 33 | 8 |
P value = 0.0883 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 35 | 13 |
TP53 MUTATED | 3 | 16 | 3 |
TP53 WILD-TYPE | 15 | 19 | 10 |
P value = 0.0641 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 19 | 22 | 15 | 10 |
TP53 MUTATED | 6 | 6 | 9 | 1 |
TP53 WILD-TYPE | 13 | 16 | 6 | 9 |
P value = 0.0155 (Fisher's exact test), Q value = 0.48
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 19 | 16 | 7 | 6 | 10 | 4 | 4 |
TP53 MUTATED | 5 | 6 | 1 | 0 | 7 | 3 | 0 |
TP53 WILD-TYPE | 14 | 10 | 6 | 6 | 3 | 1 | 4 |
P value = 0.642 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 20 | 24 | 22 |
TP53 MUTATED | 5 | 9 | 8 |
TP53 WILD-TYPE | 15 | 15 | 14 |
P value = 0.66 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 18 | 11 | 12 | 6 | 5 | 5 | 9 |
TP53 MUTATED | 7 | 5 | 3 | 1 | 1 | 3 | 2 |
TP53 WILD-TYPE | 11 | 6 | 9 | 5 | 4 | 2 | 7 |
P value = 0.779 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 10 | 16 | 16 | 10 | 14 |
TP53 MUTATED | 5 | 5 | 4 | 3 | 5 |
TP53 WILD-TYPE | 5 | 11 | 12 | 7 | 9 |
P value = 0.238 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 14 | 8 | 13 | 5 | 9 | 9 | 8 |
TP53 MUTATED | 7 | 3 | 4 | 0 | 2 | 5 | 1 |
TP53 WILD-TYPE | 7 | 5 | 9 | 5 | 7 | 4 | 7 |
P value = 0.0982 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 47 | 14 |
PTEN MUTATED | 2 | 3 | 1 |
PTEN WILD-TYPE | 3 | 44 | 13 |
P value = 0.322 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 35 | 13 |
PTEN MUTATED | 3 | 3 | 0 |
PTEN WILD-TYPE | 15 | 32 | 13 |
P value = 0.348 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 19 | 22 | 15 | 10 |
PTEN MUTATED | 2 | 1 | 3 | 0 |
PTEN WILD-TYPE | 17 | 21 | 12 | 10 |
P value = 0.477 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 19 | 16 | 7 | 6 | 10 | 4 | 4 |
PTEN MUTATED | 2 | 1 | 0 | 0 | 3 | 0 | 0 |
PTEN WILD-TYPE | 17 | 15 | 7 | 6 | 7 | 4 | 4 |
P value = 0.352 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 20 | 24 | 22 |
PTEN MUTATED | 1 | 4 | 1 |
PTEN WILD-TYPE | 19 | 20 | 21 |
P value = 0.0684 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 18 | 11 | 12 | 6 | 5 | 5 | 9 |
PTEN MUTATED | 5 | 0 | 0 | 0 | 0 | 1 | 0 |
PTEN WILD-TYPE | 13 | 11 | 12 | 6 | 5 | 4 | 9 |
P value = 0.0112 (Fisher's exact test), Q value = 0.36
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 10 | 16 | 16 | 10 | 14 |
PTEN MUTATED | 4 | 0 | 1 | 0 | 1 |
PTEN WILD-TYPE | 6 | 16 | 15 | 10 | 13 |
P value = 0.17 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 14 | 8 | 13 | 5 | 9 | 9 | 8 |
PTEN MUTATED | 4 | 0 | 0 | 0 | 1 | 1 | 0 |
PTEN WILD-TYPE | 10 | 8 | 13 | 5 | 8 | 8 | 8 |
P value = 0.491 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 47 | 14 |
PABPC1 MUTATED | 1 | 4 | 2 |
PABPC1 WILD-TYPE | 4 | 43 | 12 |
P value = 0.237 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 35 | 13 |
PABPC1 MUTATED | 2 | 2 | 3 |
PABPC1 WILD-TYPE | 16 | 33 | 10 |
P value = 0.206 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 19 | 22 | 15 | 10 |
PABPC1 MUTATED | 2 | 1 | 1 | 3 |
PABPC1 WILD-TYPE | 17 | 21 | 14 | 7 |
P value = 0.743 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 19 | 16 | 7 | 6 | 10 | 4 | 4 |
PABPC1 MUTATED | 2 | 1 | 2 | 1 | 1 | 0 | 0 |
PABPC1 WILD-TYPE | 17 | 15 | 5 | 5 | 9 | 4 | 4 |
P value = 0.611 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 20 | 24 | 22 |
PABPC1 MUTATED | 3 | 3 | 1 |
PABPC1 WILD-TYPE | 17 | 21 | 21 |
P value = 0.309 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 18 | 11 | 12 | 6 | 5 | 5 | 9 |
PABPC1 MUTATED | 2 | 1 | 0 | 1 | 0 | 0 | 3 |
PABPC1 WILD-TYPE | 16 | 10 | 12 | 5 | 5 | 5 | 6 |
P value = 0.691 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 10 | 16 | 16 | 10 | 14 |
PABPC1 MUTATED | 1 | 3 | 1 | 0 | 2 |
PABPC1 WILD-TYPE | 9 | 13 | 15 | 10 | 12 |
P value = 0.0442 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 14 | 8 | 13 | 5 | 9 | 9 | 8 |
PABPC1 MUTATED | 1 | 0 | 0 | 1 | 2 | 0 | 3 |
PABPC1 WILD-TYPE | 13 | 8 | 13 | 4 | 7 | 9 | 5 |
P value = 0.643 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 5 | 47 | 14 |
URGCP MUTATED | 0 | 2 | 1 |
URGCP WILD-TYPE | 5 | 45 | 13 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 35 | 13 |
URGCP MUTATED | 1 | 2 | 0 |
URGCP WILD-TYPE | 17 | 33 | 13 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 19 | 22 | 15 | 10 |
URGCP MUTATED | 1 | 1 | 1 | 0 |
URGCP WILD-TYPE | 18 | 21 | 14 | 10 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 19 | 16 | 7 | 6 | 10 | 4 | 4 |
URGCP MUTATED | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
URGCP WILD-TYPE | 18 | 15 | 7 | 6 | 9 | 4 | 4 |
P value = 0.193 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 20 | 24 | 22 |
URGCP MUTATED | 2 | 0 | 1 |
URGCP WILD-TYPE | 18 | 24 | 21 |
P value = 0.541 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 18 | 11 | 12 | 6 | 5 | 5 | 9 |
URGCP MUTATED | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
URGCP WILD-TYPE | 17 | 11 | 12 | 5 | 5 | 5 | 8 |
P value = 0.809 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 10 | 16 | 16 | 10 | 14 |
URGCP MUTATED | 1 | 1 | 0 | 0 | 1 |
URGCP WILD-TYPE | 9 | 15 | 16 | 10 | 13 |
P value = 0.411 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 14 | 8 | 13 | 5 | 9 | 9 | 8 |
URGCP MUTATED | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
URGCP WILD-TYPE | 13 | 8 | 13 | 4 | 9 | 8 | 8 |
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Mutation data file = transformed.cor.cli.txt
-
Molecular subtypes file = KICH-TP.transferedmergedcluster.txt
-
Number of patients = 66
-
Number of significantly mutated genes = 4
-
Number of Molecular subtypes = 8
-
Exclude genes that fewer than K tumors have mutations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.